Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-789/KEYNOTE-789)

PHASE3CompletedINTERVENTIONAL
Enrollment

492

Participants

Timeline

Start Date

June 29, 2018

Primary Completion Date

January 17, 2023

Study Completion Date

October 2, 2023

Conditions
Non-small Cell Lung Cancer
Interventions
BIOLOGICAL

pembrolizumab

IV infusion

DRUG

pemetrexed

IV infusion

DRUG

carboplatin

IV infusion

DRUG

cisplatin

IV infusion

DRUG

saline solution

IV infusion

Trial Locations (158)

100

National Taiwan University Hospital ( Site 0500), Taipei

104

Mackay Memorial Hospital ( Site 0503), Taipei

231

Taipei Tzu Chi Hospital ( Site 0512), New Taipei City

235

Taipei Medical University Shuang Ho Hospital ( Site 0508), New Taipei City

300

National Taiwan University Hospital Hsin-Chu Branch ( Site 0511), Hsinchu

333

Chang Gung Medical Foundation. Linkou ( Site 0502), Taoyuan District

704

National Cheng Kung University Hospital ( Site 0506), Tainan City

833

Kaohsiung Chang Gung Memorial Hospital ( Site 0507), Kaohsiung City

970

Hualien Tzu Chi Medical Center-Hospital ( Site 0510), Hualien City

2050

Chris OBrien Lifehouse ( Site 0200), Camperdown

2145

Westmead Hospital ( Site 0201), Westmead

3084

Austin Health ( Site 0203), Heidelberg

3128

Eastern Health ( Site 0202), Box Hill

10022

Memorial Sloan Kettering Cancer Center-Rockerfeller Patient Pavilion ( Site 0049), New York

10043

AOU San Luigi Gonzaga di Orbassano ( Site 1300), Orbassano

10408

National Cancer Center ( Site 0400), Gyeonggi-do

10601

White Plains Hospital Center for Cancer Care ( Site 0014), White Plains

11042

Monter Cancer Center ( Site 0054), Lake Success

11217

Taipei Veterans General Hospital ( Site 0501), Taipei

12208

New York Oncology Hematology P.C ( Site 8000), Albany

13620

Seoul National University Bundang Hospital ( Site 0405), Seongnam-si

14033

CHU Caen Service de Pneumologie ( Site 0804), Caen

14050

Medica Sur S.A.B de C.V. ( Site 2003), Mexico City

14080

Instituto Nacional de Cancerologia. ( Site 2007), Tlalpan

20141

Istituto Europeo di Oncologia ( Site 1303), Milan

21000

Centre Georges Francois Leclerc ( Site 0809), Dijon

21075

Asklepios Klinikum Hamburg ( Site 0908), Hamburg

21565

Gachon University Gil Medical Center ( Site 0408), Incheon

22903

Emily Couric Clinical Cancer Center ( Site 0020), Charlottesville

25030

Hopital Jean Minjoz Besancon ( Site 0805), Besançon

26121

Pius Hospital Oldenburg ( Site 0905), Oldenburg

28034

Hospital Ramon y Cajal ( Site 1101), Madrid

28041

Hospital Universitario 12 de Octubre ( Site 1103), Madrid

28644

Chungbuk National University Hospital ( Site 0404), Cheongju-si

29010

Complejo Hospitalario Carlos Haya de Malaga ( Site 1107), Málaga

37044

C.H.U. de Tours - Hopital Bretonneau ( Site 0806), Tours

40447

China Medical University Hospital ( Site 0505), Taichung

40489

Florence Nightingale Krankenhaus ( Site 0912), Düsseldorf

40705

Taichung Veterans General Hospital ( Site 0504), Taichung

41009

Hospital Universitario Virgen Macarena ( Site 1104), Seville

44033

Ulsan University Hospital ( Site 0401), Ulsan

44280

Instituto Jaliscience de Cancerologia ( Site 2000), Guadalajara

45136

Kliniken Essen-Mitte ( Site 0900), Essen

48149

Universitaetsklinikum Muenster ( Site 0906), Münster

50006

Changhua Christian Hospital ( Site 0509), Changhua

50134

Azienda Ospedaliero Universitaria Careggi ( Site 1301), Florence

51101

Siouxland Regioinal Cancer Center dba June E. Nylen Cancer Center ( Site 0065), Sioux City

53226

Froedtert Hospital & the Medical College of Wisconsin ( Site 0041), Milwaukee

54100

Centre D Oncologie de Gentilly ( Site 0810), Nancy

55435

Southdale Cancer Care, University of Minnesota Medical Center- Edina ( Site 0048), Edina

60201

North Shore University Health System ( Site 0030), Evanston

64111

Saint Lukes Hospital of Kansas City ( Site 0060), Kansas City

68000

Oaxaca Site Management Organization SC ( Site 2001), Oaxaca City

68167

Universitaetsklinikum Mannheim ( Site 0911), Mannheim

69008

Centre Leon Berard ( Site 0801), Lyon

70124

IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1305), Bari

70839

Robert Bosch Krankenhaus Klinik Schillerhoehe ( Site 0904), Gerlingen

72000

Clinique Victor Hugo ( Site 0802), Le Mans

75235

Parkland Health & Hospital System ( Site 2102), Dallas

75390

University of Texas Southwestern Medical Center at Dallas ( Site 0035), Dallas

80131

Azienda Ospedaliera dei Colli V. Monaldi ( Site 1306), Napoli

84106

Utah Cancer Specialists ( Site 0001), Salt Lake City

86021

CHU Poitiers ( Site 0803), Poitiers

90048

Cedars-Sinai Medical Center ( Site 0070), Los Angeles

92160

Hopital Prive d'Antony ( Site 0811), Antony

92868

UC Irvine Medical Center/Chao Family Comprehensive Cancer Center ( Site 0092), Orange

93940

Pacific Cancer Care ( Site 0058), Monterey

95403

St. Joseph Heritage Healthcare ( Site 0003), Santa Rosa

97074

Klinikum Wuerzburg Mitte gGmbH ( Site 0901), Würzburg

97213

Providence Portland Medical Center ( Site 0097), Portland

97227

Kaiser Permanente Northwest ( Site 0037), Portland

98039

Ospedale San Vincenzo di Taormina ( Site 1302), Taormina

100021

Cancer Hospital Chinese Academy of Medical Sciences ( Site 0717), Beijing

100032

Peking Union Medical College Hospital ( Site 0703), Beijing

100036

Beijing Cancer Hospital ( Site 0718), Beijing

130021

The First Hospital of Jilin University ( Site 0702), Changchun

130103

Jilin Cancer Hospital ( Site 0705), Changchun

150081

The Affiliated Tumour Hospital of Harbin Medical University ( Site 0706), Harbin

200030

Shanghai Chest Hospital ( Site 0700), Shanghai

200433

Zhongshan Hospital Fudan University ( Site 0712), Shanghai

210000

Jiangsu Cancer Hospital ( Site 0719), Nanjing

230088

The First Affiliated Hospital of Anhui Medical University ( Site 0721), Hefei

310003

The First Affiliated Hospital.Zhejiang University ( Site 0713), Hangzhou

310016

Sir Run Run Shaw Hospital School of Medicine, Zhejiang University ( Site 0715), Hangzhou

310022

Zhejiang Cancer Hospital ( Site 0716), Hangzhou

350014

Fujian Cancer Hospital ( Site 0723), Fuzhou

400038

Southwest Hospital, The Third Military Medical University ( Site 0725), Chongqing

410008

Xiangya Hospital of Central South University ( Site 0710), Changsha

410013

Hunan Cancer Hospital ( Site 0722), Changsha

450008

Henan Cancer Hospital ( Site 0711), Zhengzhou

710038

Tangdu Hospital ( Site 0708), Xi’an

710061

The First Affiliated Hospital of Xi an Jiaotong University ( Site 0709), Xi’an

830000

Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0701), Ürümqi

1834111

Ha Emek Medical Center ( Site 1707), Afula

3109601

Rambam Medical Center ( Site 1703), Haifa

4428164

Meir Medical Center ( Site 1701), Kfar Saba

4941492

Rabin Medical Center ( Site 1704), Petah Tikva

5265601

Chaim Sheba Medical Center. ( Site 1700), Ramat Gan

6423906

Sourasky Medical Center ( Site 1705), Tel Aviv

7830604

Barzilai Medical Center ( Site 1706), Ashkelon

8457108

Soroka Medical Center ( Site 1702), Beersheba

59075-740

Liga Norte Riograndense Contra o Cancer ( Site 1909), Natal

98700-000

Hospital de Caridade de Ijui ( Site 1907), Ijuí

95900-010

Hospital Bruno Born ( Site 1913), Lajeado

90035-903

Hospital de Clinicas de Porto Alegre ( Site 1905), Porto Alegre

90610-000

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1904), Porto Alegre

14784-400

Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 1911), Barretos

14048-900

Hosp. Clinicas da Fac. de Medicina de Ribeirao Preto - USP ( Site 1912), Ribeirão Preto

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1903), São Paulo

L6R 3J7

William Osler Health System ( Site 0100), Brampton

M4N 3M5

Sunnybrook Health Sciences, Odette Cancer Centre ( Site 0102), Toronto

M5G 2M9

Princess Margaret Cancer Centre ( Site 0104), Toronto

H3T 1E2

Jewish General Hospital ( Site 0105), Montreal

01307

Medizinische Fakultaet Carl Gustav Carus der TU Dresden ( Site 0907), Dresden

Unknown

Hong Kong Integrated Oncology Centre ( Site 0304), Hong Kong

Queen Mary Hospital ( Site 0301), Hong Kong

Queen Mary Hospital ( Site 0303), Hong Kong

Hong Kong United Oncology Centre ( Site 0306), Kowloon

Tuen Mun Hospital ( Site 0305), Tuenmen

00128

Universita Campus Bio-Medico di Roma ( Site 1304), Roma

460-0001

National Hospital Organization Nagoya Medical Center ( Site 0608), Nagoya

464-8681

Aichi Cancer Center Hospital ( Site 0612), Nagoya

470-1192

Fujita Health University Hospital ( Site 0619), Toyoake

277-8577

National Cancer Center Hospital East ( Site 0601), Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center ( Site 0616), Matsuyama

673-8558

Hyogo Cancer Center ( Site 0604), Akashi

920-8641

Kanazawa University Hospital ( Site 0617), Kanazawa

241-8515

Kanagawa Cancer Center ( Site 0609), Yokohama

573-1191

Kansai Medical University Hospital ( Site 0606), Hirakata

411-8777

Shizuoka Cancer Center Hospital and Research Institute ( Site 0602), Sunto-gun

810-8563

National Hospital Organization Kyushu Medical Center ( Site 0621), Fukuoka

812-8582

Kyushu University Hospital ( Site 0605), Fukuoka

951-8566

Niigata Cancer Center Hospital ( Site 0610), Niigata

700-8558

Okayama University Hospital ( Site 0614), Okayama

541-8567

Osaka International Cancer Institute ( Site 0611), Osaka

104-0045

National Cancer Center Hospital ( Site 0603), Tokyo

105-8470

Toranomon Hospital ( Site 0615), Tokyo

113-8677

Tokyo Metropolitan Komagome Hospital ( Site 0618), Tokyo

641-8510

Wakayama Medical University Hospital ( Site 0613), Wakayama

03080

Seoul National University Hospital ( Site 0402), Seoul

05505

Asan Medical Center ( Site 0407), Seoul

06351

Samsung Medical Center ( Site 0403), Seoul

06591

The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 0406), Seoul

08916

Hospitalo Univ. Germans Trias i Pujol ( Site 1100), Badalona

08025

Hospital de la Santa Creu i Sant Pau ( Site 1102), Barcelona

08035

Hospital Universitari Vall d Hebron ( Site 1106), Barcelona

581 85

Linkopings Universitetssjukhus ( Site 1504), Linköping

221 85

Skanes Universitetssjukhus Lund ( Site 1503), Lund

171 64

Karolinska Universitetssjukhuset Solna ( Site 1500), Solna

413 45

Sahlgrenska Universitetssjukhuset ( Site 1502), Gothenburg

BN2 5BE

Sussex University Hospitals ( Site 1003), Brighton

EH4 2XU

Western General Hospital ( Site 1009), Edinburgh

LE1 5WW

Leicester Royal Infirmary ( Site 1000), Leicester

NW1 2PG

University College London Hospitals NHS Foundation Trust ( Site 1006), London

SW10 9NH

Chelsea & Westminster Hospital ( Site 1001), London

B9 5SS

Birmingham Heartlands Hospital ( Site 1002), Birmingham

LS9 7TF

St James s University Hospital ( Site 1008), Leeds

RM7 0AG

Barking Havering and Redbridge University Hospitals NHS Trust Queen s Hospital ( Site 1004), Romford

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03515837 - Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-789/KEYNOTE-789) | Biotech Hunter | Biotech Hunter