NCT03513952 - Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 5, 2019

Primary Completion Date

September 30, 2023

Study Completion Date

April 1, 2024

Conditions

Advanced Bladder Urothelial CarcinomaAdvanced Ureter Urothelial CarcinomaMetastatic Bladder Urothelial CarcinomaMetastatic Renal Pelvis Urothelial CarcinomaMetastatic Ureter Urothelial CarcinomaMetastatic Urethral Urothelial CarcinomaMetastatic Urothelial CarcinomaRecurrent Bladder Urothelial CarcinomaRecurrent Renal Pelvis Urothelial CarcinomaRecurrent Ureter Urothelial CarcinomaRecurrent Urethral Urothelial CarcinomaStage III Bladder Cancer AJCC v8Stage III Renal Pelvis Cancer AJCC v8Stage III Ureter Cancer AJCC v8Stage III Urethral Cancer AJCC v8Stage IV Bladder Cancer AJCC v8Stage IV Renal Pelvis Cancer AJCC v8Stage IV Ureter Cancer AJCC v8Stage IV Urethral Cancer AJCC v8Stage IVA Bladder Cancer AJCC v8Stage IVB Bladder Cancer AJCC v8Unresectable Bladder Urothelial CarcinomaUnresectable Renal Pelvis Urothelial CarcinomaUnresectable Ureter Urothelial Carcinoma

Interventions

DRUG

Atezolizumab

Given IV

PROCEDURE

Biopsy

Undergo biopsy of tumor

PROCEDURE

Biospecimen Collection

Undergo collection of blood and stool samples

PROCEDURE

Computed Tomography

Undergo CT

BIOLOGICAL

Glycosylated Recombinant Human Interleukin-7

Given IM

OTHER

Laboratory Biomarker Analysis

Correlative studies

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography and Computed Tomography Scan

Undergo PET/CT

Trial Locations (9)

14263

Roswell Park Cancer Institute, Buffalo

33612

Moffitt Cancer Center, Tampa

60637

University of Chicago Comprehensive Cancer Center, Chicago

63110

Washington University School of Medicine, St Louis

70006

East Jefferson General Hospital, Metairie

92505

Kaiser Permanente-Riverside, Riverside

96813

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

98109

FHCC South Lake Union, Seattle

All Listed Sponsors

lead

National Cancer Institute (NCI)

NIH