Nivolumab Plus Ipilimumab as Neoadjuvant Therapy for Hepatocellular Carcinoma (HCC)

PHASE2CompletedINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

February 12, 2019

Primary Completion Date

May 31, 2024

Study Completion Date

May 31, 2024

Conditions
Hepatocellular Carcinoma (HCC)
Interventions
DRUG

nivolumab, ipilimumab

All enrolled subjects will receive nivolumab 3 mg/kg plus ipilimumab 1 mg/kg intravenously on day 1 of each cycle (every 3 weeks). Tumor assessment will be done after 6 weeks (2 cycles) and 12 weeks (4 cycles).

Trial Locations (8)

100

National Taiwan University Hospital, Taipei

Unknown

Chang-Gung Memorial Hospital, Kaohsiung, Kaohsiung City

China Medical University Hospital, Taichung

National Cheng-Kung University Hospital, Tainan City

Mackay Memorial Hospital, Taipei

Taipei Veterans General Hospital, Taipei

Tri-Service General Hospital, Taipei

Chang-Gung Memorial Hospital, Linkou, Taoyuan District

All Listed Sponsors
collaborator

National Taiwan University Hospital

OTHER

collaborator

Taipei Veterans General Hospital, Taiwan

OTHER_GOV

collaborator

National Cheng-Kung University Hospital

OTHER

collaborator

China Medical University Hospital

OTHER

collaborator

Chang Gung Memorial Hospital

OTHER

collaborator

Mackay Memorial Hospital

OTHER

collaborator

Tri-Service General Hospital

OTHER

lead

National Health Research Institutes, Taiwan

OTHER

NCT03510871 - Nivolumab Plus Ipilimumab as Neoadjuvant Therapy for Hepatocellular Carcinoma (HCC) | Biotech Hunter | Biotech Hunter