501
Participants
Start Date
August 22, 2018
Primary Completion Date
August 22, 2019
Study Completion Date
January 29, 2020
Vitamin C
Intravenous vitamin C (1.5 grams every 6 hours) will be administered for 4 days or until ICU discharge.
Thiamine
Intravenous thiamine (100 mg every 6 hours) will be administered for 4 days or until ICU discharge.
Hydrocortisone
Intravenous hydrocortisone (50 mg every 6 hours) will be administered for 4 days or until ICU discharge.
Vitamin C Placebo
A placebo to match intravenous vitamin C (1.5 grams every 6 hours) will be administered for 4 days or until ICU discharge.
Thiamine Placebo
A placebo to match intravenous thiamine (100 mg every 6 hours) will be administered for 4 days or until ICU discharge.
Hydrocortisone Placebo
A placebo to match intravenous hydrocortisone (50 mg every 6 hours) will be administered for 4 days or until ICU discharge. Steroids will be used when clinically indicated.
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center Weiler, The Bronx
Montefiore Medical Center Moses, The Bronx
University of Pennsylvania Health System Hospital, Philadelphia
Medical University of South Carolina, Charleston
University of Colorado Denver, Denver
Christiana Care, Newark
Medstar Washington Hospital Center, Washington D.C.
Stanford University, Stanford
Johns Hopkins Bayview, Baltimore
Thomas Jefferson University, Philadelphia
Johns Hopkins Hospital, Baltimore
University of Cincinnati Physicians Company, Cincinnati
Virginia Commonwealth University, Richmond
Sentara Healthcare, Norfolk
Oregon Health Sciences University, Portland
Henry Ford Health System, Detroit
Temple University, Philadelphia
Piedmont Healthcare, Atlanta
Grady Memorial Hospital, Atlanta
David Geffen School of Medicine at UCLA, Los Angeles
Emory University Hospital, Atlanta
Emory Saint Joseph's Hospital, Atlanta
University of Florida Jacksonville, Jacksonville
Vanderbilt University Medical Center, Nashville
University of Utah, Salt Lake City
Wake Forest University, Winston-Salem
Cleveland Clinic, Cleveland
Ohio State University Wexner Medical Center, Columbus
University of Michigan, Ann Arbor
Hennepin County Medical Center, Minneapolis
University of Maryland School of Medicine, Baltimore
Mayo Clinic, Rochester
University of Nebraska Medical Center, Omaha
Lousiana State University, New Orleans
Maricopa Integrated Health System, Phoenix
Denver Health, Denver
Intermountain Medical Center, Murray
Bon Secours, Richmond
University of Arizona, Tucson
Duke University, Durham
Yale New Haven Hospital, New Haven
Baystate Health, Springfield
The Marcus Foundation
OTHER
Emory University
OTHER