18
Participants
Start Date
March 27, 2018
Primary Completion Date
March 6, 2024
Study Completion Date
March 6, 2024
Structural Image
Patients will undergo structural and functional (rsfMRI) brain MRIs (total time= \~15 minutes) at enrollment (prior to HD-Chemo/ASCT) and approximately 3-4 months after ASCT.
Functional Image
Patients will undergo structural and functional (rsfMRI) brain MRIs (total time= \~15 minutes) at enrollment (prior to HD-Chemo/ASCT) and approximately 3-4 months after ASCT.
Digit Span subtest
Evaluates auditory attention and working memory
Brief Test of Attention
Assesses selective auditory attention
Trail Making Test (Parts A & B)
Assesses visual scanning, graphomotor speed, and setshifting
Auditory Consonant Trigrams Test
Assesses attention and susceptibility to interference
Controlled Oral Word Association Test
A timed test of verbal fluency.
Hopkins Verbal Learning Test-Revised
The HVLT-R is a test of verbal learning and recall.
The Center for Epidemiological Study-Depression
assesses perceived depression
The Functional Assessment of Chronic Illness Therapy-Fatigue Subscale, Version 4
A 13-item questionnaire designed to assess symptoms and concerns specific to the QOL of patients with fatigue
Blood draw
Blood samples will be collected at each time point (pre-ASCT; 3-4 months and post-ASCT) to assess serum levels of inflammatory cytokines.
Memorial Sloan Kettering Cancer Center, New York
Rutgers University - Data Analysis, New Brunswick
Memorial Sloan Kettering Cancer Center
OTHER