High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

June 27, 2019

Primary Completion Date

June 3, 2022

Study Completion Date

June 2, 2024

Conditions
Soft Tissue Sarcoma
Interventions
DRUG

Ascorbate

"Phase 1 dose escalation:~75gm IV three times a week~Phase II portion:~75gm IV three times a week if no dose limiting toxicities are experienced in the Phase I portion. Otherwise, ascorbate dose will be deescalated to 62.5 gm IV"

Trial Locations (1)

52242

University of Iowa Hospitals and Clinics, Iowa City

All Listed Sponsors
collaborator

University of Iowa

OTHER

lead

Mohammed Milhem

OTHER

NCT03508726 - High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas | Biotech Hunter | Biotech Hunter