NCT03507699 - Combined Immunotherapy and Radiosurgery for Metastatic Colorectal Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

December 15, 2018

Primary Completion Date

August 18, 2021

Study Completion Date

May 25, 2022

Conditions

Colorectal Neoplasms MalignantLiver Metastases

Interventions

RADIATION

Liver radiation therapy

21 Gy in three fractions to one liver metastasis

DRUG

Nivolumab Injection [Opdivo]

administered IV at a dose of 3mg/kg every 2 weeks

DRUG

Ipilimumab Injection [Yervoy]

administered IV at a dose of 1mg/kg every 6 weeks

DRUG

CMP-001

A TLR9 agonist, will be administered both into the liver metastasis (three times), and also injected subcutaneously at a dose of 5-10 mg every two weeks.

Trial Locations (1)

52621

Sheba Medical Center, Ramat Gan