Response to Anti-hypertensives in Pregnant and Postpartum Patients

PHASE4CompletedINTERVENTIONAL
Enrollment

109

Participants

Timeline

Start Date

September 11, 2017

Primary Completion Date

April 5, 2019

Study Completion Date

April 5, 2019

Conditions
Hypertension in PregnancyPreeclampsia
Interventions
DRUG

Nifedipine

Nifedipine 10mg oral will be given and the MAP will then be calculated 20 minutes after medication is given. If SBP is ≥160mmHg or DBP is ≥110mmHg, nifedipine 20mg oral will be given and the MAP will then be calculated 20 minutes after medication is given. If SBP is ≥160mmHg or DBP is ≥110mmHg, nifedipine 20mg oral will be given and the MAP will then be calculated 20 minutes after medication is given and institution specific protocol will be performed.

DRUG

Labetalol

Labetalol 20mg IV will be given over 2 minutes and the MAP will then be calculated 10 minutes after medication is given. If SBP is ≥160mmHg or DBP is ≥110mmHg, labetalol 40mg IV will be given over 2 minutes and the MAP will then be calculated 10 minutes after medication is given. If SBP is ≥160mmHg or DBP is ≥110mmHg, labetalol 80mg IV will be given over 2 minutes and the MAP will then be calculated 10 minutes after medication is given. If SBP is ≥160mmHg or DBP is ≥110mmHg, then another medication will be chosen based on institution specific protocol.

Trial Locations (2)

10019

Mount Sinai West, New York

11219

Maimonides Hospital, Brooklyn

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Mount Sinai Hospital, New York

OTHER

collaborator

Maimonides Medical Center

OTHER

lead

Icahn School of Medicine at Mount Sinai

OTHER