Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS

PHASE3CompletedINTERVENTIONAL
Enrollment

496

Participants

Timeline

Start Date

June 21, 2018

Primary Completion Date

July 23, 2020

Study Completion Date

July 23, 2020

Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG

Levosimendan

Levosimendan 1 mg capsule for oral administration

DRUG

Placebo for levosimendan

Placebo capsule for oral administration

Trial Locations (104)

9

Beaumont Hospital - Ireland, Dublin

1090

Medizinische Universität Wien, Vienna

2050

Brain and Mind Centre, Camperdown

3000

Universitaire Ziekenhuis Leuven, Leuven

3162

Calvary Health Care Bethlehem, Caulfield South

4000

Centre Hospitalier Régional de la Citadelle, Liège

4029

Royal Brisbane and Women's Hospital, Brisbane

4840

Salzkammergut-Klinikum Vöcklabruck, Vöcklabruck

5042

Flinders Medical Centre, Bedford Park

6020

Universität Innsbruck, Innsbruck

6150

Perron Institute for Neurological and Translational Science, Murdoch

9000

Algemeen Ziekenhuis St. Lucas Gent, Ghent

10003

Mount Sinai Beth Israel, New York

10021

Hospital for Special Surgery, New York

10032

Columbia Presbyterian Hospital, New York

10126

Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino, Torino

13353

Charité Universitätsmedizin Berlin - Campus Virchow-Klinikum, Berlin

14011

Hospital Universitario Reina Sofia, Córdoba

14186

Karolinska Universitetssjukhuset, Stockholm

15212

Allegheny General Hospital, Pittsburgh

15213

University of Pittsburgh Medical Center, Pittsburgh

16132

Azienda Ospedaliera Universitaria San Martino, Genova

18147

Universitätsmedizin Rostock, Rostock

19107

Hospital of the University of Pennsylvania, Philadelphia

19140

Temple University School of Medicine, Philadelphia

20007

Georgetown University, Washington D.C.

20037

The George Washington Medical Faculty Associates - Foggy Bottom North Pavilion, Washington D.C.

20521

Turku University Hospital, Turku

21205

The Johns Hopkins Hospital, Baltimore

27100

ICS Maugeri Spa SB, Pavia

27705

Duke University Medical Center, Durham

28016

Hospital San Rafael - Madrid, Madrid

28100

Azienda Ospedaliera Universitaria-Maggiore della Carità di Novara, Novara

28207

Neurosciences Institute - Neurology Charlotte, Charlotte

30322

Emory University School of Medicine, Atlanta

30625

Medizinische Hochschule Hannover, Hanover

30912

Augusta University, Augusta

32209

University of Florida Health - Jacksonville, Jacksonville

32224

Mayo Clinic - Jacksonville, Jacksonville

32611

University of Florida, Gainesville

33308

Providence Holy Cross Medical Center, Fort Lauderdale

33612

University of South Florida, Tampa

34295

Hôpital Gui de Chauliac, Montpellier

37044

Centre Hospitalier Régional et Universitaire de Tours Hôpital Bretonneau, Tours

40202

Kentucky Neuroscience Research, Louisville

40536

University of Kentucky Chandler Medical Center, Lexington

43210

The Ohio State University, Columbus

45131

Alfried Krupp Krankenhaus Rüttenscheid, Essen

46026

Hospital Universitario y Politécnico de La Fe, Valencia

48013

Hospital de Basurto, Bilbao

48149

Universitätsklinikum Münster, Münster

49007

University of Michigan, Ann Arbor

53130

Etelä-Karjalan keskussairaala, Lappeenranta

53226

Froedtert Hospital, Milwaukee

55905

Mayo Clinic - Rochester, Rochester

56126

Azienda Ospedaliero-Universitaria Pisana Ospedale Santa Chiara, Pisa

60611

Northwestern University Feinberg School of Medicine, Chicago

60637

University of Chicago, Chicago

63110

Washington University School of Medicine, St Louis

65191

Deutsche Klinik für Diagnostik, Wiesbaden

68506

Neurology Associates, Lincoln

75214

Texas Neurology, Dallas

77030

Nerve and Muscle Center of Texas, Houston

80907

Colorado Springs Neurological Associates, Colorado Springs

84108

University of Utah - Imaging & Neurosciences Center, Salt Lake City

85006

Phoenix Neurological Associates, Phoenix

85028

Neuromuscular Research Center and Neuromuscular Clinic of Arizona, Phoenix

87042

Centre Hospitalier Universitaire de Limoges, Limoges

89081

Universitätsklinikum Ulm, Ulm

90048

Cedars-Sinai Medical Center, Los Angeles

90737

Norrlands Universitetssjukhus, Umeå

92868

University of California Irvine, Orange

94115

California Pacific Medical Center, San Francisco

97213

Providence Brain and Spine Institute, Portland

98122

Swedish Neuroscience Institute, Seattle

98195

University of Washington Medical Center, Seattle

92037-0886

University of California San Diego, La Jolla

06053

Hospital for Special Care, New Britain

02114

Massachusetts General Hospital, Boston

55130-5302

HealthPartners Specialty Center, Saint Paul

27157-1023

Wake Forest University Baptist Medical Center, Winston-Salem

97201-3098

Oregon Health and Science University, Portland

05401

University of Vermont Medical Center, Burlington

T3M 1M4

Alberta Health Services - Neuromuscular Clinic, Calgary

T6G 2G3

University of Alberta, Edmonton

E3B 0C7

Stan Cassidy Centre for Rehabilitation, Fredericton

E1C 2Z3

Moncton Hospital, Southeast Regional Health Authority, Moncton

L8N 3Z5

McMaster University Medical Centre, Hamilton

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

H2L 4M1

Centre De Recherche Du Centre Hospitalier de l'Universite de Montreal - Hopital Notre-Dame, Montreal

H3A 2B4

Montreal Neurological Institute and Hospital, Montreal

G1J 1Z4

Centre Hospitalier Affilie Universitaire de Quebec, Québec

00029

Neurologian Poliklinikka - Meilahden Tornisairaala 3, Helsinki

06202

Hôpital Pasteur, Nice

01307

Universitätsklinikum Carl Gustav Carus, Dresden

07747

Universitätsklinikum Jena, Jena

0016

Policlinico Umberto I di Roma, Roma

1105 AZ

Academisch Medisch Centrum, Amsterdam

3584 CG

Universitair Medisch Centrum Utrecht - Rudolf Magnus Instituut voor Neurowetenschappen, Utrecht

08207

Hospital Universitari de Bellvitge, Barcelona

651 85

Centralsjukhuset Karlstad, Karlstad

E1 1BB

Barts Health NHS Trust, London

SE5 9RS

King's College Hospital NHS Foundation Trust, London

L9 7LJ

The Walton Centre NHS Foundation Trust, Liverpool

All Listed Sponsors
lead

Orion Corporation, Orion Pharma

INDUSTRY

NCT03505021 - Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS | Biotech Hunter | Biotech Hunter