Venetoclax and Vincristine in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

74

Participants

Timeline

Start Date

August 3, 2018

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2028

Conditions
Recurrent Adult Lymphoblastic LymphomaRecurrent B Acute Lymphoblastic LeukemiaRecurrent B Lymphoblastic LymphomaRecurrent T Acute Lymphoblastic LeukemiaRecurrent T Lymphoblastic LymphomaRefractory B Acute Lymphoblastic LeukemiaRefractory B Lymphoblastic LymphomaRefractory T Acute Lymphoblastic LeukemiaRefractory T Lymphoblastic Lymphoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Lumbar Puncture

Undergo lumbar puncture

PROCEDURE

Positron Emission Tomography

Undergo PET scan

DRUG

Venetoclax

Given PO

DRUG

Vincristine Liposomal

Given IV

DRUG

Vincristine Sulfate

Given IV

Trial Locations (170)

10065

Memorial Sloan Kettering Cancer Center, New York

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

29601

Saint Francis Hospital, Greenville

29607

Saint Francis Cancer Center, Greenville

32209

University of Florida Health Science Center - Jacksonville, Jacksonville

53226

Medical College of Wisconsin, Milwaukee

54017

Cancer Center of Western Wisconsin, New Richmond

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Clinic-Minocqua Center, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55008

Cambridge Medical Center, Cambridge

55082

Lakeview Hospital, Stillwater

55092

Fairview Lakes Medical Center, Wyoming

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

Minnesota Oncology - Burnsville, Burnsville

55362

Monticello Cancer Center, Monticello

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55371

Fairview Northland Medical Center, Princeton

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

59802

Saint Patrick Hospital - Community Hospital, Missoula

60153

Loyola University Medical Center, Maywood

60160

Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park

60491

Loyola Medicine Homer Glen, Homer Glen

60527

Loyola Center for Health at Burr Ridge, Burr Ridge

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

62002

Saint Anthony's Health, Alton

62269

Cancer Care Center of O'Fallon, O'Fallon

HSHS Saint Elizabeth's Hospital, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

Saint Mary's Hospital, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65065

Lake Regional Hospital, Osage Beach

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

72205

CARTI Cancer Center, Little Rock

72903

Mercy Hospital Fort Smith, Fort Smith

73120

Mercy Hospital Oklahoma City, Oklahoma City

77030

Houston Methodist Hospital, Houston

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

85054

Mayo Clinic Hospital in Arizona, Phoenix

85259

Mayo Clinic in Arizona, Scottsdale

87106

University of New Mexico Cancer Center, Albuquerque

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97756

Saint Charles Health System-Redmond, Redmond

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

32224-9980

Mayo Clinic in Florida, Jacksonville

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07740

Monmouth Medical Center, Long Branch

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

08755

Community Medical Center, Toms River

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

00959-5060

Cancer Center-Metro Medical Center Bayamon, Bayamón

00961

Puerto Rico Hematology Oncology Group, Bayamón

00674

Doctors Cancer Center, Manatí

00917

San Juan Community Oncology Group, San Juan

00927

Centro Comprensivo de Cancer de UPR, San Juan

PROncology, San Juan

00936

San Juan City Hospital, San Juan

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

ECOG-ACRIN Cancer Research Group

NETWORK

NCT03504644 - Venetoclax and Vincristine in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia | Biotech Hunter | Biotech Hunter