NCT03503630 - Short-course Radiation Followed by mFOLFOX-6 Plus COMPOUND 2055269 for Locally-advanced Rectal Adenocarcinoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

July 20, 2018

Primary Completion Date

March 15, 2021

Study Completion Date

July 2, 2024

Conditions

Locally Advanced Rectal Cancer

Interventions

DRUG

COMPOUND 2055269

COMPOUND 2055269 to be given every 2 weeks with chemotherapy for 6 cycles

RADIATION

Radiation Therapy

Radiotherapy 25 Gy to be given on Days 1-5

DRUG

mFOLFOX

Given every 2 weeks for 6 cycles

PROCEDURE

Total Mesorectal Excision

Surgery to be done 2-3 weeks after last cycle of chemotherapy and COMPOUND 2055269

Trial Locations (3)

King Hussein Cancer Center, Amman

American University of Beirut Medical Center, Beirut

Hôtel Dieu de France, Beirut