Nedaplatin Versus Cisplatin and Capecitabine Versus Fluorouracil in IC + CCRT for Locoregionally Advanced NPC

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

632

Participants

Timeline

Start Date

June 30, 2018

Primary Completion Date

June 30, 2024

Study Completion Date

June 30, 2026

Conditions
Nasopharyngeal Carcinoma
Interventions
DRUG

docetaxel, nedaplatin, and capecitabine

Patients receive docetaxel(60 mg/m2 on day 1), nedaplatin (60 mg/m2 on day 1) and capecitabine (625 mg/m2 bid, on Days 1 to 14) every three weeks for three cycles before the radiotherapy.

DRUG

nedaplatin

Patients receive concurrent nedaplatin (100mg/m2) every three weeks for two cycles during radiotherapy.

DRUG

docetaxel, cisplatin, and fluorouracil

Patients receive docetaxel (60mg/m2 on day 1), cisplatin (60mg/m2 on day 1) and fluorouracil (600mg/m2 on Days 1 to 5) every three weeks for three cycles before the radiotherapy.

DRUG

cisplatin

Patients receive concurrent cisplatin (100mg/m2) every three weeks for two cycles during radiotherapy.

DRUG

docetaxel, cisplatin, and capecitabine

Patients receive docetaxel(60 mg/m2 on day 1), cisplatin (60 mg/m2 on day 1) and capecitabine (625 mg/m2 bid, on Days 1 to 14) every three weeks for three cycles before the radiotherapy.

DRUG

docetaxel, nedaplatin, and fluorouracil

Patients receive docetaxel (60mg/m2 on day 1), nedaplatin (60mg/m2 on day 1) and fluorouracil (600mg/m2 on Days 1 to 5) every three weeks for three cycles before the radiotherapy.

Trial Locations (1)

510060

Sun Yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
collaborator

Tongji Hospital

OTHER

collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

collaborator

Peking University

OTHER

collaborator

Air Force Military Medical University, China

OTHER

collaborator

Second Affiliated Hospital of Soochow University

OTHER

collaborator

The First Affiliated Hospital of Guangdong Pharmaceutical University

OTHER

collaborator

First People's Hospital of Foshan

OTHER

collaborator

Fifth Affiliated Hospital, Sun Yat-Sen University

OTHER

collaborator

Cancer Hospital of Guizhou Province

OTHER

collaborator

Xiangya Hospital of Central South University

OTHER

collaborator

Jilin Provincial Tumor Hospital

OTHER

collaborator

Henan Cancer Hospital

OTHER_GOV

collaborator

Hunan Cancer Hospital

OTHER

collaborator

Cancer Hospital of Guangxi Medical University

OTHER

collaborator

Affiliated Cancer Hospital & Institute of Guangzhou Medical University

OTHER

collaborator

Zhejiang Cancer Hospital

OTHER

lead

Sun Yat-sen University

OTHER