S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis

PHASE2CompletedINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

June 6, 2018

Primary Completion Date

August 30, 2023

Study Completion Date

September 19, 2023

Conditions
Amorphous, Eosinophilic, and Acellular DepositConstipationDiarrheaEarly SatietyGastrointestinal HemorrhageHepatomegalyLymphadenopathyMacroglossiaNauseaPrimary Systemic AmyloidosisPurpuraRecurrent Primary AmyloidosisRefractory Primary Amyloidosis
Interventions
BIOLOGICAL

Isatuximab

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

Trial Locations (345)

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, Harrison

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

14642

University of Rochester, Rochester

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

Lehigh Valley Hospital-Hazleton, Hazleton

18301

Pocono Medical Center, East Stroudsburg

25401

WVUH-Berkely Medical Center, Martinsburg

26101

Camden Clark Medical Center, Parkersburg

26330

United Hospital Center, Bridgeport

26506

West Virginia University Healthcare, Morgantown

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

Wayne Memorial Hospital, Goldsboro

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27834

East Carolina University, Greenville

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Onslow Memorial Hospital, Jacksonville

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

33331

Cleveland Clinic-Weston, Weston

37343

Pulmonary Medicine Center of Chattanooga-Hixson, Hixson

37363

Memorial GYN Plus, Ooltewah

37404

Memorial Hospital, Chattanooga

40004

Flaget Memorial Hospital, Bardstown

40165

Jewish Hospital Medical Center South, Shepherdsville

40202

Jewish Hospital, Louisville

40215

Saints Mary and Elizabeth Hospital, Louisville

40245

Jewish Hospital Medical Center Northeast, Louisville

40504

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

44106

Case Western Reserve University, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

48044

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb

Michigan Breast Specialists-Macomb Township, Macomb

48054

Great Lakes Cancer Management Specialists-Doctors Park, East China Township

48088

Advanced Breast Care Center PLLC, Warren

48093

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren

Macomb Hematology Oncology PC, Warren

Michigan Breast Specialists-Warren, Warren

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

IHA Hematology Oncology Consultants-Brighton, Brighton

Saint Joseph Mercy Brighton, Brighton

48118

IHA Hematology Oncology Consultants-Chelsea, Chelsea

Saint Joseph Mercy Chelsea, Chelsea

48154

Hope Cancer Clinic, Livonia

Saint Mary Mercy Hospital, Livonia

48188

IHA Hematology Oncology Consultants-Canton, Canton

Saint Joseph Mercy Canton, Canton

48197

IHA Hematology Oncology Consultants-Ann Arbor, Ypsilanti

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Ascension Saint John Hospital, Detroit

Academic Hematology Oncology Specialists, Grosse Pointe Woods

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods

Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods

48309

Great Lakes Cancer Management Specialists-Rochester Hills, Rochester Hills

48312

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights

48334

Weisberg Cancer Treatment Center, Farmington Hills

48341

21st Century Oncology-Pontiac, Pontiac

Hope Cancer Center, Pontiac

Newland Medical Associates-Pontiac, Pontiac

Saint Joseph Mercy Oakland, Pontiac

48346

Hematology Oncology Consultants-Clarkston, Clarkston

Newland Medical Associates-Clarkston, Clarkston

48453

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette

48503

Genesee Cancer and Blood Disease Treatment Center, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48723

Caro Cancer Center, Caro

48764

Ascension Saint Joseph Hospital, Tawas City

48912

Sparrow Hospital, Lansing

50266

Mercy Medical Center-West Lakes, West Des Moines

50314

Medical Oncology and Hematology Associates-Laurel, Des Moines

Mercy Medical Center - Des Moines, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

Mercy Cancer Center-West Lakes, Clive

50801

Greater Regional Medical Center, Creston

51503

Alegent Health Mercy Hospital, Council Bluffs

54017

Cancer Center of Western Wisconsin, New Richmond

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Clinic - Weston Center, Weston

54482

Marshfield Clinic Stevens Point Center, Stevens Point

54548

Marshfield Clinic-Minocqua Center, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55008

Cambridge Medical Center, Cambridge

55082

Lakeview Hospital, Stillwater

55092

Fairview Lakes Medical Center, Wyoming

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55362

Monticello Cancer Center, Monticello

55369

Fairview Maple Grove Medical Center, Maple Grove

55371

Fairview Northland Medical Center, Princeton

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview-Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55905

Mayo Clinic, Rochester

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59102

Saint Vincent Frontier Cancer Center, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59804

Community Medical Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60153

Loyola University Medical Center, Maywood

60160

Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park

60504

Rush - Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle on Vermilion, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62226

Cancer Care Specialists of Illinois-Swansea, Swansea

Southwest Illinois Health Services LLP, Swansea

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63628

Parkland Health Center-Bonne Terre, Bonne Terre

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64057

Centerpoint Medical Center LLC, Independence

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64111

Saint Luke's Hospital of Kansas City, Kansas City

64132

Research Medical Center, Kansas City

64507

Heartland Regional Medical Center, Saint Joseph

65109

Capital Region Southwest Campus, Jefferson City

65613

Central Care Cancer Center - Bolivar, Bolivar

66044

Lawrence Memorial Hospital, Lawrence

66209

Menorah Medical Center, Overland Park

66213

Saint Luke's South Hospital, Overland Park

66219

Kansas Institute of Medicine Cancer and Blood Center, Lenexa

Minimally Invasive Surgery Hospital, Lenexa

67208

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Cancer Center of Kansas - Wichita, Wichita

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

68046

Midlands Community Hospital, Papillion

68122

Alegent Health Immanuel Medical Center, Omaha

Hematology and Oncology Consultants PC, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

CHI Health Saint Francis, Grand Island

68845

Heartland Hematology and Oncology, Kearney

68847

CHI Health Good Samaritan, Kearney

70121

Ochsner Medical Center Jefferson, New Orleans

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77802

Saint Joseph Regional Cancer Center, Bryan

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

The Medical Center of Aurora, Aurora

80026

Good Samaritan Medical Center, Lafayette

80033

SCL Health Lutheran Medical Center, Wheat Ridge

80045

University of Colorado Hospital, Aurora

80113

Comprehensive Cancer Care and Research Institute of Colorado LLC, Englewood

Swedish Medical Center, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80122

Littleton Adventist Hospital, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80138

Parker Adventist Hospital, Parker

Rocky Mountain Cancer Centers-Parker, Parker

80204

Denver Health Medical Center, Denver

80206

National Jewish Health-Main Campus, Denver

80209

The Women's Imaging Center, Denver

80210

Porter Adventist Hospital, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

SCL Health Saint Joseph Hospital, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

Western Surgical Care, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80260

National Jewish Health-Northern Hematology Oncology, Thornton

Rocky Mountain Cancer Centers-Thornton, Thornton

80301

Boulder Community Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80401

Mountain Blue Cancer Care Center, Golden

National Jewish Health-Western Hematology Oncology, Golden

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80524

Poudre Valley Hospital, Fort Collins

80539

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81008

Rocky Mountain Cancer Centers - Pueblo, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

81501

Saint Mary's Hospital and Regional Medical Center, Grand Junction

82001

Cheyenne Regional Medical Center-West, Cheyenne

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83301

Saint Luke's Mountain States Tumor Institute-Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83617

Walter Knox Memorial Hospital, Emmett

83619

Saint Luke's Mountain States Tumor Institute - Fruitland, Fruitland

83642

Idaho Urologic Institute-Meridian, Meridian

Saint Luke's Mountain States Tumor Institute - Meridian, Meridian

83686

Saint Alphonsus Medical Center-Nampa, Nampa

Saint Luke's Mountain States Tumor Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Mountain States Tumor Institute, Boise

83814

Kootenai Medical Center, Coeur d'Alene

83854

Kootenai Cancer Center, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95901

Fremont - Rideout Cancer Center, Marysville

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Oncology and Hematology Care Southeast, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97227

Kaiser Permanente Northwest, Portland

97239

Oregon Health and Science University, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97756

Saint Charles Health System-Redmond, Redmond

97814

Saint Alphonsus Medical Center-Baker City, Baker City

97914

Saint Alphonsus Medical Center-Ontario, Ontario

98003

Saint Francis Hospital, Federal Way

98022

Saint Elizabeth Hospital, Enumclaw

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98112

Kaiser Permanente Washington, Seattle

98166

Highline Medical Center-Main Campus, Burien

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

Harrison Medical Center, Bremerton

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98499

Saint Clare Hospital, Lakewood

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

06418

Smilow Cancer Hospital-Derby Care Center, Derby

06824

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

06473

Yale-New Haven Hospital North Haven Medical Center, North Haven

06477

Smilow Cancer Hospital-Orange Care Center, Orange

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

32224-9980

Mayo Clinic in Florida, Jacksonville

04330

Harold Alfond Center for Cancer Care, Augusta

04401

Eastern Maine Medical Center, Bangor

04915

Waldo County General Hospital, Belfast

04005

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford, Biddeford

04412

Lafayette Family Cancer Center-EMMC, Brewer

04268

Stephens Memorial Hospital, Norway

04073

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford, Sanford

02118

Boston Medical Center, Boston

01104

Mercy Medical Center, Springfield

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

Memorial Sloan Kettering Monmouth, Middletown

98122-4307

Swedish Medical Center-First Hill, Seattle

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK

NCT03499808 - S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis | Biotech Hunter | Biotech Hunter