Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality

PHASE4CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

July 27, 2018

Primary Completion Date

May 9, 2021

Study Completion Date

May 9, 2021

Conditions
Suicidal Ideation
Interventions
DRUG

Transdermal Estradiol + Placebo

.1mg/24hr transdermal estradiol for 14 days starting day 7 after positive urine luteinizing hormone test, plus twice daily placebo pills during the same time frame.

DRUG

Oral Micronized Progesterone + Placebo

100mg oral micronized progesterone twice daily for 14 days starting day 7 after positive urine luteinizing hormone test, plus weekly application of a placebo patch during the same time frame.

DRUG

Placebos

Twice daily placebo pills for 14 days starting day 7 after positive urine luteinizing hormone test, plus weekly application of a placebo patch during the same time frame.

Trial Locations (1)

60612

University of Illinois Neuropsychiatric Institute, Chicago

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

University of Illinois at Chicago

OTHER

NCT03498313 - Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality | Biotech Hunter | Biotech Hunter