Evaluation of Functional Magnetic Resonance Imaging (fMRI) in Patients Who Speak Two Languages Fluently

CompletedOBSERVATIONAL
Enrollment

32

Participants

Timeline

Start Date

March 30, 2018

Primary Completion Date

May 8, 2025

Study Completion Date

May 8, 2025

Conditions
GliomaGlioma of BrainGlioma of Spinal Cord
Interventions
BEHAVIORAL

Multilingual Aphasia Examination

"For patients only prior to MRI scans.~The MAE contains eleven subtests in five categories which may be used to assess both languages in bilinguals and the participant's primary language in monolinguals: Oral Expression, Spelling, Oral Verbal Understanding, Reading, and Rating Scales. Subtests are scored for accuracy of individual items on a three-point scoring system (0, 1, 2). Contained within these domains are The Token Test, Aural Comprehension of Words and Phrases and Visual Naming which naturally parallel fMRI and direct cortical stimulation behavioral assays already in place for clinical use (phonemic fluency, auditory responsive naming and confrontation naming respectively). The MAE is expected to take under 50 minutes."

DIAGNOSTIC_TEST

Language paradigms + RS fMRI

10 monolingual patients: 2 language paradigms + RS fMRI = 7x3 = 21 minutes 10 early bilingual patients: 2 language paradigms+ RS fMRI = 7x3 = 21 minutes 10 late bilingual patients: 2 language paradigms+ RS fMRI = 7x3 = 21 minutes

DIAGNOSTIC_TEST

Language paradigms + RS fMRI + one anatomical sequence

"10 monolingual English volunteers: 2 task language paradigms\* + 1 Resting State fMRI + one anatomical sequence for a total of approximately 25 minutes.~10 late bilingual volunteers: 4 language paradigms (2 English + 2 Spanish) + 1 Resting State fMRI + one anatomical sequence for a total of approximately 39 minutes.~10 early bilingual volunteers: 4 language paradigms (2 English + 2 Spanish) + 1 Resting State fMRI + one anatomical sequence for a total of approximately 39 minutes."

Trial Locations (3)

10021

Memorial Sloan Kettering Cancer Center, New York

10031

City College of New York, New York

55100

IMT School of Advance Studies Lucca, Lucca

All Listed Sponsors
lead

Memorial Sloan Kettering Cancer Center

OTHER

NCT03496181 - Evaluation of Functional Magnetic Resonance Imaging (fMRI) in Patients Who Speak Two Languages Fluently | Biotech Hunter | Biotech Hunter