A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease

CompletedOBSERVATIONAL
Enrollment

714,582

Participants

Timeline

Start Date

February 22, 2018

Primary Completion Date

April 6, 2018

Study Completion Date

June 25, 2018

Conditions
Diabetes Mellitus, Type 2Cardiovascular Diseases
Interventions
DRUG

Canagliflozin

No intervention or treatment assignment imposed by this study. Participants received canagliflozin as a part of routine clinical practice.

DRUG

Empagliflozin

No intervention or treatment assignment imposed by this study. Participants received empagliflozin as a part of routine clinical practice.

DRUG

Dapagliflozin

No intervention or treatment assignment imposed by this study. Participants received dapagliflozin as a part of routine clinical practice.

DRUG

Dipeptidyl Peptidase-4 (DPP-4) Inhibitors

No intervention or treatment assignment imposed by this study. Participants received DPP-4 inhibitor as a part of routine clinical practice. DPP-4 inhibitors includes: alogliptin, linagliptin, saxagliptin, sitagliptin, vildagliptin.

DRUG

Glucagon-like Peptide-1 (GLP-1) Agonist

No intervention or treatment assignment imposed by this study. Participants received GLP-1 agonist as a part of routine clinical practice. GLP-1 agonists includes: albiglutide, dulaglutide, exenatide, liraglutide, lixisenatide.

DRUG

Anti-hyperglycemic Agents (AHA)

No intervention or treatment assignment imposed by this study. Participants received other selected AHA as a part of routine clinical practice. Other select AHAs includes: acarbose, bromocriptine, miglitol, nateglinide, repaglinide.

DRUG

Thiazolidinediones (TZD)

No intervention or treatment assignment imposed by this study. Participants received TZD as a part of routine clinical practice. TZDs includes: pioglitazone, rosiglitazone, troglitazone.

DRUG

Sulfonylureas (SU)

No intervention or treatment assignment imposed by this study. Participants received SU as a part of routine clinical practice. SUs includes: glipizide, glyburide, glimepiride, chlorpropamide, tolazamide, tolbutamide, acetohexamide

DRUG

Insulin

No intervention or treatment assignment imposed by this study. Participants received Insulin as a part of routine clinical practice.

Trial Locations (1)

08560

Janssen Investigative Site, Titusville

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY

NCT03492580 - A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease | Biotech Hunter | Biotech Hunter