Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

352

Participants

Timeline

Start Date

June 25, 2018

Primary Completion Date

January 13, 2026

Study Completion Date

September 13, 2026

Conditions
Colorectal NeoplasmsCarcinoma, Non-Small-Cell LungExocrine Pancreatic CancerCarcinoma, Squamous Cell of Head and Neck
Interventions
DRUG

tisotumab vedotin

Given into the vein (IV; intravenously)

DRUG

pembrolizumab

200mg or 400mg given by IV

DRUG

carboplatin

AUC 5mg/mL per minute or AUC 3.3mg/mL per minute given by IV

DRUG

cisplatin

100mg/m\^2 given by IV

Trial Locations (157)

10021

Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street)., New York

10604

MSK Westchester., Harrison

11553

MSK Nassau., Uniondale

11725

MSK Commack., Commack

13005

CEPCM/CHU Timone, Batiment 3 -1er etage, Marseille

19104

Hospital of the University of Pennsylvania, Philadelphia

20141

Istituto Europeo di Oncologia, Milan

21231

John Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore

21287

John Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore

22903

Cancer Center IDS Pharmacy, Charlottesville

University of Virginia Comprehensive Cancer Center, Charlottesville

22908

University of Virginia Health System, Charlottesville

UVA Health System; Attention: GI Team, Charlottesville

25030

CHRU de Besançon- Hopital Jean Minjoz, Besançon

25123

U.O. Oncologia, Brescia

26600

LBM UNIBIO Jean Herve Lebras, Tain-l'Hermitage

26800

Laboratoire Cerballiance Portes Les Valence, Portes-lès-Valence

27157

Atrium Health Wake Forest Baptist Health, Winston-Salem

Atrium Health Wake forest Baptist, Winston-Salem

27514

North Carolina Basnight Cancer Hospital Infusion Pharmacy, Chapel Hill

UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill

27599

The University of North Carolina at Chapel Hill, Chapel Hill

27609

Duke Raleigh Hospital, Raleigh

27710

Duke Cancer Center, Durham

Investigational Chemotherapy Service, Durham

28034

Hospital Universitario Ramon y Cajal, Madrid

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital, Atlanta

Investigational Drug Service, Emory University Clinic, Atlanta

The Emory Clinic, Atlanta

Winship Cancer Institute, Emory University, Atlanta

32025

Family Focus Eye Care - Lake City, Lake City

32605

Family Focus Eye Care - Gainesville, Gainesville

32608

UF Health Davis Cancer Pavilion and Shands Med Plaza, Gainesville

UF Health Shands Cancer Hospital, Gainesville

32610

UF Health Shands Hospital, Gainesville

33612

Moffitt Cancer Center McKinley Hospital, Tampa

Moffitt Cancer Center, Tampa

Richard M Schulze Family Foundation Outpatient Center at McKinley Campus, Tampa

38300

Laboratoire Oriade Noviale Medipole, Bourgoin

Laboratoire Oriade Noviale Tixier, Bourgoin

40202

Norton Cancer Institute Pharmacy, Louisville

Norton Cancer Institute, Downtown, Louisville

Norton Hospital, Louisville

40206

The Eye Care Institute, Louisville

40217

Norton Audubon Hospital, Louisville

Norton Cancer Institute, Audubon Hospital Campus, Louisville

40241

Norton Brownsboro Hospital, Louisville

Norton Cancer Institute, Brownsboro Hospital Campus, Louisville

44277

Hopital prive du Confluent S.A.S., Nantes

L'hôpital Privé du Confluent - Pharmacie, Nantes

46219

Community Health Network, Inc., Indianapolis

46227

Community Health Network, Inc., Indianapolis

46250

Community Health Network, Inc., Indianapolis

46256

Community Health Network, Inc., Indianapolis

47014

IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino Amadori- IRST S.r.l, Meldola (Fc)

IRST IRCCS - Farmacia Oncologica, Meldola (FC)

47841

Ospedale Cervesi di Cattolica-AUSL Romagna, Cattolica

47923

Ospedale degli Infermi -AUSL Romagna, Rimini

48018

PO Ospedale degli Infermi Faenza, AUSL Romagna, Faenza

48022

Ospedale Umberto I di Lugo, AUSL della Romagna, SSR Emilia-Romagna, Lugo

48121

Oncologia Medica, Ospedale Civile S. Maria delle Croci, Ravenna

Farmacia Oncologica c/o Ospedale S.Maria delle Croci-AUSL Romagna, Ravenna

48201

Karmanos Cancer Institute, Detroit

48334

Karmanos Cancer Institute Weisberg Cancer Treatment Center, Farmington Hills

51100

Ospedale S.Jacopo di Pistoia, AUSL Toscana centro, SST, Pistoia

55426

Oncology Research, HealthPartners Institute, Saint Louis Park

Park Nicollet Frauenshuh Cancer Center, Saint Louis Park

55905

Mayo Clinic Rochester, Rochester

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

Northwestern Medicine Kishwaukee Hospital, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

Northwestern Medicine Delnor Hospital, Geneva

60422

Ingalls Family Care Center (Infusion Center), Flossmoor

Primary Healthcare Associates, Flossmoor

60426

Ingalls Memorial Hospital, Harvey

Primary Healthcare Associates, Harvey

UChicago Medicine Ingalls Memorial, Harvey

60451

University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox

60462

The University of Chicago Medicine Center for Advanced Care Orland Park, Orland Park

60477

Primary Healthcare Associates, Tinley Park

UChicago Medicine at Ingalls - Tinley Park, Tinley Park

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern Medical Group, Chicago

Northwestern Memorial Hospital, Chicago

UChicago Medicine - River East, Chicago

60637

University of Chicago Medical Center, Chicago

63031

Siteman Cancer Center - North County, Florissant

63110

Barnes-Jewish Hospital, St Louis

Washington University - Investigational Drug Service Pharmacy, St Louis

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center - South County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center - St. Peters, City of Saint Peters

66205

The University of Kansas Cancer Center ,Investigational Drug Services, Fairway

The University of Kansas Clinical Research Center, Fairway

The University of Kansas Cancer Center, Westwood

69373

The Centre Léon Bérard, Lyon

76135

Vincentius-Diakonissen-Klinken Gag Augenklinik, Karlsruhe

76137

Vincentius-Diakonissen-Kliniken gAG Medizinische Klinik 2, Karlsruhe

Vincentius-Diakonissen-Klinken Gag Radiologisches Institut, Karlsruhe

77030

The University of Texas MD Anderson Cancer Center, Houston

77380

Renovatio Clinical., The Woodlands

79410

Joe Arrington Cancer Research and Treatment Center, Lubbock

80131

AOU Università degli studi della Campania Luigi Vanvitelli, Policlinico di Napoli, Napoli

Azienda Ospedaliera Universitaria - Universita della Campania Luigi Vanvitelli, Napoli

80524

Poudre Valley Hospital, Fort Collins

80525

Eye Center of Northern Colorado, Fort Collins

80528

Cancer Care & Hematology - Fort Collins, Fort Collins

Eye Center of Northern Colorado, Fort Collins

80538

Cancer Care & Hematology - Loveland, Loveland

80634

Cancer Care & Hematology - Greeley, Greeley

92093

UC San Diego/Moores Cancer Center, La Jolla

92150

Hôpital Foch Pharmacie - Essais Cliniques, Suresnes

Hôpital Foch, Suresnes

94805

Gustave Roussy, Villejuif

95124

Stanford Cancer Center South Bay, San Jose

95817

University of California Davis Medical Center, Sacramento

University of California, Davis Comprehensive Cancer Center, Sacramento

97006

OHSU Knight Cancer Institute, Beaverton, Beaverton

97030

OHSU Knight Cancer Institute, Gresham, Gresham

97062

OHSU Knight Cancer Institute, Tualatin, Tualatin

97210

OHSU Knight Cancer Institute, Northwest Portland, Portland

97216

OHSU Knight Cancer Institute, East Portland, Portland

97239

OHSU Research Pharmacy Services, Portland

Oregon Health and Science University Research Pharmacy Services, Portland

Oregon Health and Science University, Portland

98109

Fred Hutchinson Cancer Center, Seattle

06510

Simlow Cancer Hospitalat Yale-New Haven, New Haven

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Brigham and Women's Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

07920

MSK Basking Ridge., Basking Ridge

07748

MSK Monmouth, Middletown

07645

MSK Bergen, Montvale

02903

Rhode Island Hospital, Providence

02906

The Miriam Hospital, Providence

T6G 1Z2

Cross Cancer Institute, Edmonton

69424 CEDEX 03

Lbmms Du Chu de Lyon, Lyon

01190

Synlab Bourgogne Pont de Vaux, Pont-de-Vaux

01600

Laboratoire Trevoux-Dyomedea Neolab, Trévoux

00128

UOC Oncologia Medica, Rome

08916

Institut Catala D 'Oncologia-Hospital Germans Trias I Pujol,Servicio de Oncologia Medica, Barcelona

08243

ALTHAIA, Xarxa Assistencial Universitaria de Manresa., Manresa

08023

Hospital Quironsalud Barcelona Instituto Oncologico Baselga, Barcelona

Hospital Quiron Salud Barcelona Plaza, Barcelona

Vall d'Hebron University Hospital, Barcelona

08028

Hospital Universitario Dexeus - Grupo Quirónsalud, Barcelona

08035

Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca, Barcelona

08908

Institut Catala d'Oncologia (ICO BADALONA), Barcelona

SE1 9RT

Clinical Research Facility - Clinical Research Facility, London

Guys and St Thomas Hospital, London

Se1 9Rt

Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital, London

SM2 5PT

Pharmacy Stores (CCR5916) - The Royal Marsden, Sutton

Royal Marsden Hospital NHS Foundation Trust - HNTU, Sutton

The Royal Marsden NHS Foundation trust (RM), Sutton

SW3 6JJ

The Royal Marsden NHS Foundation Trust (RM)., London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genmab

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Seagen, a wholly owned subsidiary of Pfizer

INDUSTRY