59
Participants
Start Date
March 7, 2018
Primary Completion Date
November 7, 2021
Study Completion Date
February 7, 2022
PET examination with radiopharmaceutical drug [18F] DPA-714
Using a Biograph 6 Truepoint device. Establishment of a venous route. It will be injected 4 MBq / kg of 18F-DPA714 by the venous route with a maximum dose of 280 MBq. The patient will be placed along the orbito-meatal line. Brain acquisition will begin 60 minutes post-injection
MRI examination
MRI device Philips Achieva - 3Tesla. The acquisition of the data will include different sequences (anatomical MRI, diffusion MRI, resting fMRI) and will last a total of one hour (installation and removal of the patient in the machine included).anatomical MRI associated with FLAIR (Fluid Attenuation Inversion Recovery) and diffusion tensor (tractography).
Blood samples
Characterization of the TSPO phenotype (mitochondrial translocase) for tracer affinity
Hospital, Toulouse
University Hospital, Toulouse
OTHER