348
Participants
Start Date
January 4, 2019
Primary Completion Date
June 29, 2021
Study Completion Date
June 29, 2021
Dexmedetomidine
Intravenous infusion with electric syringe of Dexmedetomidine 0,4ug/ml. Rate 0,1ug/kg/h to 1,4ug/kg/h. Nightly infusion from 20:00 to 08:00. The drug is titrated to achieve RASS between -1 and 1. Modification of infusion rate by 0,1ug/kg/h is recommended with stabilization phase of 1 hour before another rate adjustment.
Sodium chloride 0.9%
Intravenous infusion with electric syringe of normal saline. Rate modifications follow the same rules as in experimental group.
CHU de Nantes, Nantes
CHU de Rennes, Rennes
CHRU de Brest, Brest
CHU de Grenoble, Grenoble
CHU la Pitié Salpétrière, Paris
CHU Poitiers, Poitiers
Angers university hospital, Angers
Clermont Ferrand university hospital, Clermont-Ferrand
Hôpital Privé Jacques Cartier, Massy
Direction Générale de l'Offre de Soins
OTHER_GOV
Baxter Healthcare Corporation
INDUSTRY
University Hospital, Brest
OTHER