TIL-ACT After NMA Chemo with IL-2 and Nivo Rescue in Metastatic Melanoma (mMEL)

Adoptive transfer of Autologous Tumor-Infiltrating Lymphocytes

Cyclophosphamide will be administered as an intravenous (IV) infusion for two days.

Fludarabine will be administered as an intravenous (IV) infusion for five days.

After TIL infusion, IL-2 (optional) will be started as a bolus administration every eight hours, for a maximum of eight doses.

Nivolumab will be administered for maximum 24 months as follows: first year: 240 mg every 2 weeks; second year: 480 mg every 4 weeks.