PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

550

Participants

Timeline

Start Date

June 10, 2016

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2028

Conditions
Endometrial Cancer Stage IEndometrial Cancer Stage II
Interventions
RADIATION

Vaginal brachytherapy

Internal radiation of the vaginal vault using a vaginal cylinder, 21 Gy in 3 out-patient sessions over 2 weeks

RADIATION

External beam radiotherapy

External beam pelvic radiotherapy on a linear accelerator, 48.6 Gy in 27 out-patients sessions over 5.5 weeks

OTHER

Observation

No radiation therapy, but active follow-up and quality of life questionnaires as in the groups who have adjuvant treatment

Trial Locations (31)

Unknown

Medical University, Vienna, Vienna

University Hospital Gent, Ghent

CEEGOG, General Faculty Hospital and First Faculty of Medicine, Charles University, Prague, Prague

GINECO group - Institut Goustave Roussy, Paris

Hôpital Européen Georges-Pompidou, Paris

Hôpital Tenon, Paris

Sankt Gertrauden Krankenhaus, Berlin

Kaiserswerther Diakonie, Düsseldorf

Evang. Kliniken Essen-Mitte, Essen

Universitatsklinikum Heidelberg, Heidelberg

Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck

Rotkreuzklinikum München, Münich

University Hospital, Tübingen

CancerTrials Ireland - St James Hospital (SLRON SJH), Dublin

CancerTrials Ireland - St Luke's Hospital (SLRON SLH), Dublin

Academic Medical Center, Amsterdam

NKI / Antoni van Leeuwenhoekhuis, Amsterdam

Radiation Therapy Group, Arnhem

Catharina Hospital, Eindhoven

Zuidwest Radiotherapy Institute, Flushing

University Medical Center Groningen, Groningen

Radiotherapy Institute Friesland, Leeuwarden

Leiden University Medical Center, Leiden

MAASTRO radiation oncology clinic, Maastricht

Radboud University Medical Center, Nijmegen

ErasmusMC Cancer Center, Rotterdam

Haaglanden Medical Center, The Hague

Verbeeten institute, Tilburg

University Medical Center Utrecht, Utrecht

Isala Clinics, Zwolle

Kantonsspital Frauenklinik Lucerne, Lucerne

All Listed Sponsors
collaborator

Dutch Cancer Society

OTHER

collaborator

Comprehensive Cancer Centre The Netherlands

OTHER

lead

Leiden University Medical Center

OTHER