453
Participants
Start Date
April 24, 2018
Primary Completion Date
October 1, 2025
Study Completion Date
December 31, 2025
Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody
"Atezolizumab will be administered as intravenous (IV) infusion at a dose of 1200 milligrams (mg) on Day 1 of each 21-day cycle (every 3 weeks) for 4 cycles during the neoadjuvant treatment phase~Atezolizumab will be administered as IV infusion at a dose of 1200 milligrams (mg) every 3 weeks for 16 cycles during the post-operative adjuvant phase"
Placebo Comparator
Placebo will be administered as IV infusion at a dose of 1200 milligrams (mg) on Day 1 of each 21-day cycle for 4 cycles during the neoadjuvant treatment phase
Nab-paclitaxel
Nab-paclitaxel 100 mg/m\^2 will be administered intravenously on Days 1, 8, and 15 of each 21 day cycle for 4 cycles during the neoadjuvant treatment phase
Pemetrexed
Pemetrexed 500 mg/m\^2 will be administered intravenously on Day 1 of each 21-day cycle for 4 cycles during the neoadjuvant treatment phase
Carboplatin
Carboplatin initial target AUC of 6 mg/mL/min will be administered intravenously on Day 1 of each 21-day cycle for 4 cycles during the neoadjuvant treatment phase
Cisplatin
Cisplatin 75 mg/m\^2 will be administered intravenously on Day 1 of each 21-day cycle for 4 cycles during the neoadjuvant treatment phase
Gemcitabine
Gemcitabine 1250 mg/m\^2 will be administered intravenously on Day 1 and 8 of each 21-day cycle for 4 cycles during the neoadjuvant treatment phase
Taipei Veterans General Hospital, Taipei
CHUV, Lausanne
Semmelweis Egyetem X, Budapest
Klinik Penzing, Vienna
Krankenhaus Nord - Klinik Floridsdorf, Vienna
Medical Oncology Centre of Rosebank, Johannesburg
St George Hospital, Kogarah
Peter MacCallum Cancer Center, Melbourne
Box Hill Hospital, Box Hill
Kepler Universitätskliniken GmbH - Med Campus III, Linz
Ordensklinikum Linz Elisabethinen, Linz
University Clinic Golnik, Golnik
UniversitätsSpital Zürich, Zurich
NYU Langone Medical Center, New York
Columbia University Medical Center, New York
Chulalongkorn Hospital, Bangkok
Northwell Health, Lake Success
University Hospital Medical Center Bezanijska kosa, Belgrade
NYU Winthrop Hospital, Mineola
St. Vincent's Hospital, Gyeonggi-do
Lehigh Valley Health Network, Allentown
Georgetown University, Washington D.C.
Washington Cancer Institute, Washington D.C.
Irccs Istituto Nazionale Dei Tumori (Int), Milan
Irccs Istituto Europeo Di Oncologia (IEO), Milan
Uni of Maryland Cancer Center, Baltimore
Virginia Cancer Specialists, PC, Fairfax
Uni Hospital in Lund, Lund
Pius-Hospital Oldenburg, Oldenburg
Hospital Clinico San Carlos, Madrid
Levine Cancer Institute, Charlotte
Hospital Regional Universitario Carlos Haya, Málaga
Clinica Universitaria de Navarra, Pamplona
IOV - Istituto Oncologico Veneto - IRCCS, Padua
Sarah Cannon Research Institute / Tennessee Oncology, Nashville
Taichung Veterans General Hospital, Xitun Dist.
Hospital Universitario Virgen Macarena, Seville
Hospital Clinico Universitario de Valencia, Valencia
Hospital Universitario la Fe, Valencia
Hospital de Basurto, Bilbao
University of Michigan, Ann Arbor
Brighton Center for Specialty Care, Brighton
Barbara Ann Karmanos Cancer Institute, Detroit
Chemotherapy SI Dnipropetrovsk MA of MOHU, Dnipropetrovsk
Kosin University Gospel Hospital, Busan
CHU Angers, Angers
Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
Minnesota Oncology Minneapolis, Minneapolis
Mayo Clinic - Rochester, Rochester
A.O. Universitaria Pisana-Ospedale Cisanello, Pisa
Lungmedicinska kliniken, Centrum för kirurgi, ortopedi och cancervård, Universitetssjukhuset, Linköping
Illinois Cancer Care, Peoria
Mercy Clinic Cancer & Hematology, Springfield
CHU Strasbourg - Nouvel Hopital Civil, Strasbourg
Nebraska Methodist Estabrook Cancer Center, Omaha
Centre Léon Bérard, Lyon
Robert Bosch Krankenhaus, Stuttgart
Texas Oncology - South Austin, Austin
Universitätsklinikum Freiburg, Freiburg im Breisgau
National Jewish Health, Denver
Rocky Mountain Cancer Center, Denver
Asklepios-Fachkliniken Muenchen-Gauting, Gauting
Hôpital d'Instruction des Armées de Sainte Anne, Toulon
Arizona Oncology, Tucson
USC Norris Cancer Center, Los Angeles
Scripps Clinic, San Diego
The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange, Orange
Klinikum der Univer Regenburg, Regensburg
Hopital d'Instruction des Armees de Begin, Saint-Mandé
UC Davis Cancer Center, Sacramento
Missionsärztliche Klinik, Gemeinnützige Gesellschaft mbH, Würzburg
Northwest Cancer Specialists - Vancouver, Vancouver
Main Military Clinical Hospital named after N.N. Burdenko, Moscow
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF, Moscow
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological), Saint Petersburg
Scientific Research Oncology Institute named after N.N. Petrov, Saint Petersburg
Shanghai Chest Hospital, Shanghai
Rambam Health Care Campus, Haifa
Meir Medical Center, Kfar Saba
Sourasky / Ichilov Hospital, Tel Aviv
Soroka Medical Center, Beersheba
Cenantron - Centro Avancado de Tratamento Oncologico, Belo Horizonte
Hospital Nossa Senhora da Conceicao, Porto Alegre
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Centre Hospitalier Saint Quentin, Saint-Quentin
Krankenhaus Martha-Maria Halle-Doelau gGmbH, Halle
Policlinico Universitario Campus Biomedico, Rome
National Hospital Organization Kyushu Cancer Center, Fukuoka
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
Hiroshima University Hospital, Hiroshima
Kobe University Hospital, Hyōgo
Hyogo Medical University Hospital, Hyōgo
Kyoto University Hospital, Kyoto
Fukushima Medical University Hospital, Miyagi
Sendai Kousei Hospital, Miyagi
Okayama University Hospital, Okayama
Kurashiki Central Hospital, Okayama
Osaka City General Hospital, Osaka
Osaka International Cancer Institute, Osaka
Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo
The Cancer Institute Hospital of JFCR, Tokyo
Tokyo Medical University Hospital, Tokyo
Uniwersyteckie Centrum Kliniczne, Gda?sk
Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II, Krakow
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad, Warsaw
Eugene Marais Hospital, Pretoria
Seoul National University Hospital, Seoul
Gangnam Severance Hospital, Seoul
Korea University Guro Hospital, Seoul
Hospital Son Llatzer, Palma de Mallorca
Corporacio Sanitaria Parc Tauli, Sabadell
Hospital Universitari Vall d'Hebron, Barcelona
Karolinska Universitetssjukhuset, Solna, Solna
Uppsala University Hospital, Uppsala
Queen Elizabeth Hospital, Birmingham
Barts and the London NHS Trust., London
The Clatterbridge Cancer Centre NHS Foundation Trust, Metropolitan Borough of Wirral
Hoffmann-La Roche
INDUSTRY