Brief Title: Study of Efficacy and Safety of Canakinumab as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) Completely Resected Non-small Cell Lung Cancer Acronym: CANOPY-A

PHASE3TerminatedINTERVENTIONAL
Enrollment

1,382

Participants

Timeline

Start Date

March 16, 2018

Primary Completion Date

March 17, 2022

Study Completion Date

February 7, 2023

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Canakinumab

200 mg of canakinumab administered subcutaneously on day 1 of every 21-day cycle for 18 cycles. Canakinumab solution for injection was provided by Novartis as ready-to-use pre-filled syringes to be administered by study personnel.

DRUG

Placebo

Placebo administered subcutaneously on day 1 of every 21-day cycle for 18 cycles. Placebo solution for injection was provided by Novartis as ready-to-use pre-filled syringes to be administered by study personnel.

Trial Locations (283)

34

Novartis Investigative Site, Surquillo

41

Novartis Investigative Site, San Borja

112

Novartis Investigative Site, Tbilisi

652

Novartis Investigative Site, Saida

970

Novartis Investigative Site, Hualien City

1000

Novartis Investigative Site, Ljubljana

1229

Novartis Investigative Site, Makati City

1303

Novartis Investigative Site, Sofia

1407

Novartis Investigative Site, Sofia

1434

Novartis Investigative Site, Tripoli

1708

Novartis Investigative Site, Fribourg

1756

Novartis Investigative Site, Sofia

1784

Novartis Investigative Site, Sofia

2045

Novartis Investigative Site, Törökbálint

3004

Novartis Investigative Site, Drammen

3010

Novartis Investigative Site, Bern

5021

Novartis Investigative Site, Bergen

6000

Novartis Investigative Site, Batumi

8036

Novartis Investigative Site, Graz

8200

Novartis Investigative Site, Veszprém

9019

Novartis Investigative Site, Tromsø

9020

Novartis Investigative Site, Klagenfurt

10002

Novartis Investigative Site, Taipei

10043

Novartis Investigative Site, Orbassano

10300

Novartis Investigative Site, Bangkok

10330

Novartis Investigative Site, Bangkok

10400

Novartis Investigative Site, Bangkok

10700

Novartis Investigative Site, Bangkok

10990

Novartis Investigative Site, Pulau Pinang

10999

Novartis Investigative Site, Beirut

11217

Novartis Investigative Site, Taipei

11526

Novartis Investigative Site, Athens

11941

Novartis Investigative Site, Amman

12351

Novartis Investigative Site, Berlin

13125

Novartis Investigative Site, Berlin

13915

Novartis Investigative Site, Marseille

14004

Novartis Investigative Site, Córdoba

14165

Novartis Investigative Site, Berlin

15562

Novartis Investigative Site, Athens

15706

Novartis Investigative Site, Santiago de Compostela

17019

Novartis Investigative Site, La Rochelle

18547

Novartis Investigative Site, Athens

20132

Novartis Investigative Site, Milan

20133

Novartis Investigative Site, Milan

20900

Novartis Investigative Site, Monza

22031

Virginia Cancer Specialists Fairfax Northern Virginia, Fairfax

22947

Novartis Investigative Site, Großhansdorf

24153

Oncology and Hematology Associates of Southwest Virginia Inc ., Salem

28006

Novartis Investigative Site, Madrid

28009

Novartis Investigative Site, Madrid

28041

Novartis Investigative Site, Madrid

28644

Novartis Investigative Site, Cheongju-si

29200

Novartis Investigative Site, Brest

31400

Novartis Investigative Site, Toulouse

32429

Novartis Investigative Site, Minden

33081

Novartis Investigative Site, Aviano

33176

Advanced Medical Specialties Drug Ship - 2, Miami

33305

Novartis Investigative Site, Taoyuan District

33401

Florida Cancer Specialists, West Palm Beach

33604

Novartis Investigative Site, Pessac

33705

Florida Cancer Specialists North, St. Petersburg

33901

Florida Cancer Specialists, Fort Myers

34059

Novartis Investigative Site, Montpellier

34303

Novartis Investigative Site, Istanbul

34474

Florida Cancer Affiliates of Ocala, Ocala

34899

Novartis Investigative Site, Pendik Istanbul

35100

Novartis Investigative Site, Padua

35575

Novartis Investigative Site, Izmir

37203

Sarah Cannon Research Institute, Nashville

37404

Chattanooga Oncology and Hematology Associates PC Chattanooga Oncology, Chattanooga

38320

Novartis Investigative Site, San Cristóbal de La Laguna

39008

Novartis Investigative Site, Santander

40002

Novartis Investigative Site, Khon Kaen

40201

Novartis Investigative Site, Taichung

40447

Novartis Investigative Site, Taichung

40705

Novartis Investigative Site, Taichung

41013

Novartis Investigative Site, Seville

42551

Novartis Investigative Site, Velbert

42699

Novartis Investigative Site, Solingen

44106

Louis Stokes Cleveland Department of Veterans Affairs MC ., Cleveland

44791

Novartis Investigative Site, Bochum

44805

Novartis Investigative Site, Saint-Herblain Cédex

45147

Novartis Investigative Site, Essen

46010

Novartis Investigative Site, Valencia

47014

Novartis Investigative Site, Meldola

48100

Novartis Investigative Site, Ravenna

48108

Novartis Investigative Site, Busan

49124

Novartis Investigative Site, Georgsmarienhütte

49933

Novartis Investigative Site, Angers

50006

Novartis Investigative Site, Changhua

50200

Novartis Investigative Site, Chaingmai

51109

Novartis Investigative Site, Cologne

52074

Novartis Investigative Site, Aachen

57001

Novartis Investigative Site, Thessaloniki

58100

Novartis Investigative Site, Holon

58128

Novartis Investigative Site, Jeollanam-do

59000

Novartis Investigative Site, Lille

59100

Novartis Investigative Site, Kuala Lumpur

60126

Novartis Investigative Site, Ancona

60612

Rush University Medical Center Regulatory, Chicago

63000

Novartis Investigative Site, Clermont-Ferrand

64109

Novartis Investigative Site, Bayonne

67091

Novartis Investigative Site, Strasbourg

68105

VA Nebraska-W IA Health Care System ., Omaha

69126

Novartis Investigative Site, Heidelberg

69677

Novartis Investigative Site, Bron

70124

Novartis Investigative Site, Bari

70839

Novartis Investigative Site, Gerlingen

72037

Novartis Investigative Site, Le Mans

72703

Highlands Oncology Group ., Fayetteville

75014

Novartis Investigative Site, Paris

75231

Novartis Investigative Site, Paris

75246

Texas Oncology MamieMcFaddenWardCtr, Dallas

80054

Novartis Investigative Site, Amiens

80501

Rocky Mountain Cancer Centers Denver-Mdtn(Bone&MarrowTransp), Longmont

81377

Novartis Investigative Site, München

82131

Novartis Investigative Site, Gauting

82445

Novartis Investigative Site, Kaohsiung City

83301

Novartis Investigative Site, Kaohsiung City

83500

Novartis Investigative Site, La Seyne-sur-Mer

84902

Novartis Investigative Site, Avignon

86000

Novartis Investigative Site, Poitiers

89081

Novartis Investigative Site, Ulm

90095

University of California at Los Angeles, Los Angeles

90110

Novartis Investigative Site, Songkhla

90419

Novartis Investigative Site, Nuremberg

90720

Cancer and Blood Specialty Clinic, Los Alamitos

92150

Novartis Investigative Site, Suresnes

93105

Sansum Clinic, Santa Barbara

93586

Novartis Investigative Site, Kuching

94000

Novartis Investigative Site, Créteil

97074

Novartis Investigative Site, Würzburg

99089

Novartis Investigative Site, Erfurt

100000

Novartis Investigative Site, Hanoi

100036

Novartis Investigative Site, Beijing

100039

Novartis Investigative Site, Beijing

110011

Novartis Investigative Site, Shenyang

110041

Novartis Investigative Site, Shenyang

110221

Novartis Investigative Site, Bogotá

130021

Novartis Investigative Site, Changchun

143423

Novartis Investigative Site, Moscow Region Istra Village

150054

Novartis Investigative Site, Yaroslavl

163045

Novartis Investigative Site, Arkhangelsk

166830

Novartis Investigative Site, El Achrafiyé

192148

Novartis Investigative Site, Saint Petersburg

196603

Novartis Investigative Site, Pushkin Saint Petersburg

197022

Novartis Investigative Site, Saint Petersburg

197758

Novartis Investigative Site, Saint Petersburg

200032

Novartis Investigative Site, Shanghai

200433

Novartis Investigative Site, Shanghai

210008

Novartis Investigative Site, Nanjing

215004

Novartis Investigative Site, Suzhou

230001

Novartis Investigative Site, Hefei

236006

Novartis Investigative Site, Kaliningrad

249036

Novartis Investigative Site, Obninsk

250117

Novartis Investigative Site, Jinan

300000

Novartis Investigative Site, Tianjin

300052

Novartis Investigative Site, Tianjin

310003

Novartis Investigative Site, Hangzhou

310022

Novartis Investigative Site, Hangzhou

350001

Novartis Investigative Site, Fujian

390011

Novartis Investigative Site, Ryazan

400022

Novartis Investigative Site, Mumbai

400037

Novartis Investigative Site, Chongqing

400124

Novartis Investigative Site, Cluj-Napoca

407280

Novartis Investigative Site, Floreşti

410013

Novartis Investigative Site, Changsha

450008

Novartis Investigative Site, Zhengzhou

510000

Novartis Investigative Site, Guangzhou

518020

Novartis Investigative Site, Shenzhen

524000

Novartis Investigative Site, Zhanjing

563000

Novartis Investigative Site, Zunyi

610041

Novartis Investigative Site, Chengdu

610044

Novartis Investigative Site, Chengdu

644013

Novartis Investigative Site, Omsk

700160

Novartis Investigative Site, Kolkata

700483

Novartis Investigative Site, Iași

710061

Novartis Investigative Site, Xi’an

999077

Novartis Investigative Site, Tuenmen

3109601

Novartis Investigative Site, Haifa

7500006

Novartis Investigative Site, Santiago

7500921

Novartis Investigative Site, Santiago

94304-1207

VA Palo Alto Health Care System CRLX030A2301, Palo Alto

67214-3728

Cancer Center of Kansas Dept.ofCancerCtr.ofKansas, Wichita

97401-8122

Oncology Associates of Oregon, PC, Eugene

C1426ANZ

Novartis Investigative Site, CABA

B7600FZN

Novartis Investigative Site, Mar del Plata

S2000DSV

Novartis Investigative Site, Rosario

S200KZE

Novartis Investigative Site, Rosario

X5016KEH

Novartis Investigative Site, Córdoba

A-3500

Novartis Investigative Site, Krems

A 1090

Novartis Investigative Site, Vienna

86015-520

Novartis Investigative Site, Londrina

64049-200

Novartis Investigative Site, Teresina

14784 400

Novartis Investigative Site, Barretos

01246 000

Novartis Investigative Site, São Paulo

04014-002

Novartis Investigative Site, São Paulo

T6G 1Z2

Novartis Investigative Site, Edmonton

E1C 6Z8

Novartis Investigative Site, Moncton

B3H 1V7

Novartis Investigative Site, Halifax

H2W 1T8

Novartis Investigative Site, Montreal

GIV 4G5

Novartis Investigative Site, Québec

703 84

Novartis Investigative Site, Ostrava Vitkovice

128 21

Novartis Investigative Site, Prague

0144

Novartis Investigative Site, Tbilisi

0159

Novartis Investigative Site, Tbilisi

0160

Novartis Investigative Site, Tbilisi

09113

Novartis Investigative Site, Chemnitz

01307

Novartis Investigative Site, Dresden

07548

Novartis Investigative Site, Gera

06120

Novartis Investigative Site, Halle

D-04347

Novartis Investigative Site, Leipzig

115 27

Novartis Investigative Site, Athens

GR14564

Novartis Investigative Site, Athens

Unknown

Novartis Investigative Site, Hong Kong

Novartis Investigative Site, Kowloon

IS-101

Novartis Investigative Site, Reykjavik

422 004

Novartis Investigative Site, Nashik

110 085

Novartis Investigative Site, Delhi

06129

Novartis Investigative Site, Perugia

00189

Novartis Investigative Site, Roma

464 8681

Novartis Investigative Site, Nagoya

466 8560

Novartis Investigative Site, Nagoya

036 8563

Novartis Investigative Site, Hirosaki

791-0280

Novartis Investigative Site, Matsuyama

820-8505

Novartis Investigative Site, Iizuka

070-8644

Novartis Investigative Site, Asahikawa

060 8648

Novartis Investigative Site, Sapporo

670-8520

Novartis Investigative Site, Himeji

920-8641

Novartis Investigative Site, Kanazawa

028-3695

Novartis Investigative Site, Shiwa-gun

236 0051

Novartis Investigative Site, Yokohama

241-8515

Novartis Investigative Site, Yokohama

981-1293

Novartis Investigative Site, Natori-shi

573-1191

Novartis Investigative Site, Hirakata

541-8567

Novartis Investigative Site, Osaka

591-8555

Novartis Investigative Site, Sakai

350-1298

Novartis Investigative Site, Hidaka

411 8777

Novartis Investigative Site, Sunto Gun

113-8431

Novartis Investigative Site, Bunkyo Ku

104 0045

Novartis Investigative Site, Chuo Ku

105-8470

Novartis Investigative Site, Minato Ku

755-0241

Novartis Investigative Site, Ube

810-8563

Novartis Investigative Site, Fukuoka

545-8586

Novartis Investigative Site, Osaka

641-8510

Novartis Investigative Site, Wakayama

0424

Novartis Investigative Site, Oslo

0801

Novartis Investigative Site, Panama City

31-826

Novartis Investigative Site, Krakow

62 500

Novartis Investigative Site, Konin

10-288

Novartis Investigative Site, Olsztyn

60-693

Novartis Investigative Site, Poznan

35-021

Novartis Investigative Site, Rzeszów

02 781

Novartis Investigative Site, Warsaw

1769-001

Novartis Investigative Site, Lisbon

4454 513

Novartis Investigative Site, Matosinhos Municipality

4100-180

Novartis Investigative Site, Porto

010991

Novartis Investigative Site, Bucharest

08308

Novartis Investigative Site, Seoul

03080

Novartis Investigative Site, Seoul

03722

Novartis Investigative Site, Seoul

05505

Novartis Investigative Site, Seoul

08916

Novartis Investigative Site, Badalona

08036

Novartis Investigative Site, Barcelona

08907

Novartis Investigative Site, L'Hospitalet de Llobregat

CH 1211

Novartis Investigative Site, Geneva

06200

Novartis Investigative Site, Ankara

01250

Novartis Investigative Site, Adana

CB2 0QQ

Novartis Investigative Site, Cambridge

TR1 3LJ

Novartis Investigative Site, Truro

GL53 7AN

Novartis Investigative Site, Cheltenham

CH63 4JY

Novartis Investigative Site, Metropolitan Borough of Wirral

IP4 5PD

Novartis Investigative Site, Ipswich

GU2 7XX

Novartis Investigative Site, Guildford

B9 5SS

Novartis Investigative Site, Birmingham

BS2 8HN

Novartis Investigative Site, Bristol

LE1 5WW

Novartis Investigative Site, Leicester

EC14 7BE

Novartis Investigative Site, London

NW3 2QG

Novartis Investigative Site, London

NG5 1PB

Novartis Investigative Site, Nottingham

OX3 7LJ

Novartis Investigative Site, Oxford

PR2 9HT

Novartis Investigative Site, Preston

ST4 6QG

Novartis Investigative Site, Stoke-on-Trent

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