Rotation or Change of Biotherapy After TNF Blocker Treatment Failure for Axial Spondyloarthritis

PHASE4CompletedINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

December 14, 2018

Primary Completion Date

September 21, 2024

Study Completion Date

October 1, 2024

Conditions
Axial Spondyloarthritis
Interventions
DRUG

Secukinumab

Secukinumab : 150 mg per week for 5 weeks, and then every month by subcutaneous injection

DRUG

TNF blocker

"TNF blocker (originator or biosimilar) :~* infliximab: 5mg/kg per IV infusion at weeks 0, 2, 6, and then every 6 weeks,~* etanercept: 50mg per week in subcutaneous injection,~* adalimumab: 40mg every other week in subcutaneous injection,~* certolizumab: 400mg every other week 3 times, and then 200mg every other week or 400mg per month in subcutaneous injections,~* golimumab: 50mg every month in subcutaneous injection, in case of overweight (\>100kg) an inadequate response, 100mg every month is allow."

BIOLOGICAL

blood specimen

Blood specimen at each visits for measurement of bDMARS blockers concentration and anti-drug antibody concentration

Trial Locations (35)

42055

CHU Saint-Etienne, Saint-Etienne

67200

CHU STRASBOURG - Hautepierre, Strasbourg

Unknown

CHU d'Angers, Angers

CHRU Besançon, Besançon

APHP- Hôpital Avicenne, Bobigny

CHU Bordeaux, Bordeau

CHRU Brest, Brest

CHU Clermont-Ferrand, Clermont-Ferrand

CHU de Grenoble Alpes, Grenoble

CHD Vendée, La Roche-sur-Yon

CH Le Mans, Le Mans

CHRU Lille, Lille

Hôpital Saint-Philibert, Lomme

CH Lyon SUD, Lyon

Hôpital Edouard Herriot, Lyon

CHRU Montpellier, Montpellier

CHU Montpellier - 2 - Unité Clinique thérapeutique des Maladies Ostéo-Articulaires, Montpellier

CHU Nancy, Nancy

CHU de Nantes, Nantes

CHU de Nice, Nice

CHR d'Orléans, Orléans

APHP - Hôpital Ambroise Paré, Paris

APHP - Hôpital Bichat, Paris

APHP - Hôpital Cochin, Paris

APHP - Hôpital Henri Mondor, Paris

APHP - Hôpital Lariboisière, Paris

APHP - Hôpital Pitié-Salpétrière, Paris

APHP - Hôpital Saint-Antoine, Paris

APHP - Kremlin-Bicêtre, Paris

CHU de Poitiers, Poitiers

CHU Reims, Reims

CHU de Rouen, Rouen

CHU Toulouse, Toulouse

CHRU Tours, Tours

CH Princesse de Grace, Monaco

All Listed Sponsors
collaborator

Ministry of Health, France

OTHER_GOV

lead

Centre Hospitalier Universitaire de Saint Etienne

OTHER

NCT03445845 - Rotation or Change of Biotherapy After TNF Blocker Treatment Failure for Axial Spondyloarthritis | Biotech Hunter | Biotech Hunter