Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

January 1, 2015

Primary Completion Date

July 1, 2025

Study Completion Date

December 31, 2025

Conditions
Ulcerative ColitisUlcerative Colitis ExacerbationProtozoan InfectionsHelminth Infection
Interventions
DIAGNOSTIC_TEST

parasitological diagnostics (coproscopy)

Three stool samples for parasitological examination will be taken from ulcerative colitis patients at 1-2 days interval.

DRUG

Nitazoxanide 500Mg Oral Tablet

Tab. nitazoxanide by a 1.0 g/day (two pills) twice over orally for 14 consecutive days

DRUG

Mesalazine 250Mg Tablet and nitazoxanide 500Mg Oral Tablet

Tab. nitazoxanide by a 1.0 g/day (one pill - 500 mg) twice over orally and mesalazine 1.5 g/day (one pill - 500 mg) three times a day orally for 14 consecutive days

DRUG

Mesalazine 250Mg

Tab. mesalazine ≥3 g/day (one pill - 500 mg) three times a day orally for 14 consecutive days

DRUG

Placebo tabletes

Tab. Placebo (shugar pills) will be given to the participants

All Listed Sponsors
lead

Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan

OTHER_GOV

NCT03441893 - Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis | Biotech Hunter | Biotech Hunter