A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation

PHASE3TerminatedINTERVENTIONAL
Enrollment

77

Participants

Timeline

Start Date

April 17, 2018

Primary Completion Date

October 13, 2022

Study Completion Date

October 13, 2022

Conditions
Dilated CardiomyopathyLamin A/C Gene Mutation
Interventions
DRUG

ARRY-371797 (PF-07265803)

400 mg twice daily (BID)

OTHER

Placebo

BID

Trial Locations (107)

2318

Sykehuset Innlandet HF Hamar, Hamar

3000

UZ Leuven, Leuven

6132

Ospedale Santa Maria Della Misericordia Perugia, Perugia - Località S. Andrea Delle Fratte

9300

Onze-Lieve-Vrouwziekenhuis, Aalst

10016

NYU School of Medicine / NYU Langone Health, New York

10032

Columbia University Irving Medical Center, New York

Columbia University/Presbyterian Hospital - Vivian & Seymour Milstein Family Heart Center, New York

14004

C.H. Regional Reina Sofia - PPDS, Córdoba

Hospital General Universitario Reina Sofia, Córdoba

15006

Complexo Hospitalario Universitario A Coruña, A Coruña

15781

Centro de Farmacovigilancia de Galicia, Santiago de Compostela

19104

University of Pennsylvania Hospital, Philadelphia

20010

Medstar Washington Hospital Center, Washington D.C.

25123

Azienda Ospedaliera Spedali Civili di Brescia, Brescia

27100

Fondazione IRCCS Policlinico San Matteo di Pavia, Pavia

IRCCS Pavia - Istituti Clinici Scientifici Maugeri Spa ? Società Benefit, Pavia

28222

Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda

Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda

29425

Medical University of South Carolina - PPDS, Charleston

30120

Hospital Universitario Virgen de la Arrixaca, El Palmar

30322

Centers for Heart Failure Therapy, Atlanta

Emory University Hospital, Atlanta

31904

Columbus Regional Research Institute, Columbus

33606

USF Health, Tampa

33609

Florida Cardiovascular Institute PA, Tampa

33756

Innovative Research of West Florida, Clearwater

34149

Ospedale Di Cattinara, Trieste

Ospedale Di Cattinara, Trieste

35233

University of Alabama at Birmingham Hospital, Birmingham

University of Alabama at Birmingham the Kirklin Clinic, Birmingham

35249

IDS Pharmacy at UAB Hospital, Birmingham

35294

Cardiovascular Clinical Trials Unit, Birmingham

36312

Complejo Hospitalario Universitario de Vigo - H. Alvaro Cunqueiro, Vigo

36608

CB Flock Research Corporation, Mobile

37388

Tennessee Center for Clinical Trials, Tullahoma

38138

Stern Cardiovascular Foundation Inc, Germantown

43210

Ohio State University Wexner Medical Center, Columbus

44195

The Cleveland Clinic Foundation, Cleveland

48670

MyMichigan Medical Center Midland, Midland

50134

Azienda Ospedaliera Universitaria Careggi, Florence

Lacopo Olivotto, Azienda Ospedaliera Universitaria Careggi, Florence

Azienda Ospedaliera Universitaria Careggi, Florence

53713

Meriter Hospital, Madison

63074

Presidio Ospedaliero Madonna del Soccorso, San Benedetto del Tronto

63110

Washington University Center For Advanced Medicine, St Louis

Washington University Center for Outpatient Health, St Louis

Washington University School of Medicine, St Louis

64060

Cardiolink Clin Trials S.C., Monterrey

Christus Muguerza Hospital Alta Especialidad, Monterrey

70124

AO Ospedale Policlinico Consorziale di Bari, Bari

Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari

75226

Baylor Scott and White Heart and Vascular Hospital, Dallas

75246

Baylor Annette C and Harold C Simmons Transplant Institute, Dallas

80045

University of Colorado Academic Offices Building, Aurora

University of Colorado Clinical and Translational Research Center, Aurora

University of Colorado Hospital, Aurora

84107

Intermountain Medical Center, Murray

85224

Chandler Regional Medical Center, Chandler

Valley Heart Rhythm Specialists, PLLC, Chandler

85297

Mercy Gilbert Medical Center, Gilbert

85712

Children's Clinic, Tucson

85713

Banner - Banner University Medical Center South, Tucson

85719

Banner - University Medical Center Tucson, Tucson

Banner University Medicine North, Tucson

85724

Banner University Medical Center Tuscon, Tucson

University of Arizona Sarver Heart Center, Tucson

90095

Ahmanson Cardiomyopathy Center Cardiovascular Genetics, Los Angeles

94305

Stanford Hospital and Clinics, Stanford

98195

University of Washington Medical Center, Seattle

85297-0425

Cardiovascular and Stem Cell Consultants, Gilbert

Cardiovascular Research Clinic, Gilbert

Dignity Health, Mercy Gilbert Medical Center, Gilbert

33606-3601

University of South Florida, Tampa

31904-6877

Columbus Cardiology Associates Research - Centricity Research - HyperCore - PPDS, Columbus

Columbus Cardiology Associates Research - IACT - HyperCore - PPDS, Columbus

31904-8946

Columbus Regional Research Institute at Talbotton - Centricity Research - HyperCore - PPDS, Columbus

83712-6246

Saint Luke's Idaho Cardiology Associates, Boise

02115

Brigham and Women's Hospital, Boston

07103

Rutgers New Jersey Medical School - Doctors Office Center, Newark

07112

Newark Beth Israel Medical Center, Newark

29425-8911

Medical University of South Carolina - PPDS, Charleston

C1093AAS

Fundacion Favaloro para la Docencia e Investigacion Medica, Buenos Aires

S2000 PBJ

Instituto CAICI, Rosario

S2000KDS

Hospital Provincial Del Centenario, Rosario

C1280AEB

Hospital Británico de Buenos Aires, Buenos Aires

S3000EOZ

Hospital Provincial Dr Jose Maria Cullen, Santa Fe

V6Z 1Y6

St. Paul's Hospital, Vancouver

B3H 1V7

Nova Scotia Health Authority (Capital District Health Authority), Halifax

B3H 3A7

NSHA QEII Health Sciences Halifax Infirmary, Halifax

K1Y 4W7

University of Ottawa Heart Institute, Ottawa

K9J 0B2

Kawartha Cardiology Clinical Trials, Peterborough

H1T 1C8

Clinical Laboratories of Montreal Heart Institute, Montreal

J1G 2E8

Centre Intégré Universitaire de santé et de services sociaux de l'Estrie Centre hospitalier, Sherbrooke

00189

Azienda Ospedaliera Sant'Andrea, Rome

06156

A.O.U. di Perugia Ospedale Santa Maria della Misericordia, Perugia

A.O.U. di Perugia Ospedale Santa Maria della Misericordia, Perugia

06132

A.O.U. di Perugia Ospedale Santa Maria Della Misericordia, Perugia

07300

Hospital Boutique Riobamba, Mexico City

Fundación de Atención e Investigación Médica Lindavista S.C., Mexico City

1105 AZ

Amsterdam UMC, Location Academic Medical Center, Amsterdam

0424

Oslo University Hospital, Rikshospitalet, Oslo

08035

Hospital Universitario Vall d'Hebrón - PPDS, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

07198

Hospital Universitario Son Llatzer, Palma de Mallorca

G51 4TF

Queen Elizabeth University Hospital - PPDS, Glasgow

EC1A 7BE

St Bartholomew's Hospital, London

SW3 6NP

Royal Brompton Hospital, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT03439514 - A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation | Biotech Hunter | Biotech Hunter