The Immune Modulation of Bilateral Paravertebral Block and Propofol in Spine Surgery.

NACompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

January 1, 2018

Primary Completion Date

August 25, 2019

Study Completion Date

September 1, 2020

Conditions
Immune Suppression
Interventions
DRUG

Total intravenous anesthesia group

Induction of general anesthesia with fentanyl, (1mcg / kg), propofol (1-2 mg / kg), atracurium (0.5 mg / kg), intubation. Anesthesia maintained using Propofol (4-6) mg/kg/h, fentanyl (0.5-1) μg/kg/h. to be modified according to analgesic needs and hemodynamics. 10mg atracurium when the 2nd twitch of train of four appears.

DRUG

Total intravenous plus block group

Ultrasound guidance identifies the paravertebral space using a linear high-frequency (10-12 MHz) probe in the transverse plane in the midline, rotate the probe to the longitudinal plane, and scan in a medial-to-lateral direction. Locate the desired segment shift from the cephalad aspect of the sacrum. The transverse scan will show a hyperechoic outline of the vertebral spinous and transverse processes. Use the loss of resistance technique. Bilaterally inject (5ml) bupivacaine 0.5% for each segment. Induction of anesthesia after 30 minutes with fentanyl, (1mcg / kg), propofol (1-2 mg / kg), atracurium (0.5 mg / kg),then prone position.

Trial Locations (1)

35516

Mansoura University Hospital, Al Mansurah

All Listed Sponsors
lead

Alaa Mazy Mazy

OTHER

NCT03437213 - The Immune Modulation of Bilateral Paravertebral Block and Propofol in Spine Surgery. | Biotech Hunter | Biotech Hunter