NCT03435003 - Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

August 28, 2017

Primary Completion Date

March 30, 2019

Study Completion Date

April 1, 2019

Conditions

Post-operative Nausea and VomitingLaparoscopic Sleeve Gastrectomy

Interventions

DRUG

Aprepitant 80 mg Oral Capsule

aprepitant 80 mg orally one hour prior to scheduled surgery

DRUG

scopolamine transdermal

scopolamine transdermal patch one hour prior to scheduled surgery

PROCEDURE

Total intravenous anesthesia

Maintenance of anesthesia without the use of inhaled anesthetics.

DRUG

Dexamethasone

Dexamethasone 8 mg intraoperatively

DRUG

Ondansetron

Ondansetron 4 mg intraoperatively. Ondansetron will be given twice. Once intraoperatively and then post- operatively.

DRUG

Reglan

Postoperatively scheduled Reglan

DRUG

Ondansetron

Postoperatively scheduled ondansetron

DRUG

Compazine

Postoperatively as needed compazine for breakthrough PONV

DRUG

Sugammadex

Reversal with sugammadex

DRUG

Propofol

Intravenous anesthesia will be maintained through IV propofol

DRUG

dexmedetomidine

maintenance of anesthesia in the intervention arm

DRUG

Fentanyl

intermittent bolus dosing of fentanyl will be used after induction for anesthesia maintenance

DRUG

Sevoflurane

inhalational anesthesia

DRUG

Desflurane

inhalational anesthesia

Trial Locations (1)

11794-8191

Stony Brook University Hospital, Stony Brook

All Listed Sponsors

lead

Stony Brook University

OTHER