A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma

PHASE3CompletedINTERVENTIONAL
Enrollment

558

Participants

Timeline

Start Date

March 15, 2018

Primary Completion Date

August 31, 2020

Study Completion Date

November 17, 2022

Conditions
Carcinoma, Hepatocellular
Interventions
DRUG

Atezolizumab

Atezolizumab will be administered by IV, 1200 mg on day 1 of each 21 day cycle

DRUG

Bevacizumab

Bevacizumab will be administered by IV, 15 mg/kg on day 1 of each 21 day cycle

DRUG

Sorafenib

Sorafenib will be administered by mouth, 400 mg twice per day, on days 1-21 of each 21-day cycle

Trial Locations (119)

100

National Taiwan Uni Hospital; Dept of Oncology, Taipei

333

Chang Gung Memorial Hospital-Linkou; Dept of Oncology, Taoyuan

710

Chi-Mei Medical Centre; Hematology & Oncology, Tainan City

2200

Bankstown-Lidcombe Hospital, Bankstown

2217

St George Hospital, Kogarah

3021

Sunshine Hospital, St Albans

5011

The Queen Elizabeth Hospital, Woodville

10016

Laura and ISAAC Perlmutter Cancer Center at NYU Langone., New York

10043

Az. Osp. S. Luigi Gonzaga; Divisione Di Oncologia Medica, Orbassano

13353

Campus Virchow-Klinikum Charité Centrum 13; Medizinische Klinik; Abt.Hepatologie u.Gastroenterologie, Berlin

13385

Hopital Timone Adultes; Gastro Enterologie, Marseille

19107

Thomas Jefferson University, Philadelphia

20007

Georgetown University, Washington D.C.

20246

Universitaetsklinikum Hamburg-Eppendorf; I. Medizinische Klinik - Gastroenterologie, Hamburg

28040

Hospital Clinico San Carlos; Servicio de Oncologia, Madrid

28046

Hospital Universitario La Paz; Servicio de Oncologia, Madrid

28050

Centro Integral Oncologico Clara Campal; Servicio de Oncología, Madrid

30625

Med. Hochschule Hannover; Gastroenterologie, Hanover

33612

Moffitt Cancer Center, Tampa

34295

Hopital Saint-Eloi; Hepatologie-Gastro-Enterologie, Montpellier

35128

IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima, Padua

44033

Ulsan University Hosiptal, Ulsan

44093

Hopital Hotel Dieu Et Hme; Hepatologie Gastro Enterologie, Nantes

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola

48202

Henry Ford Health System, Detroit

50009

Hospital Universitario Miguel Servet; Servicio de Oncologia Medica, Zaragoza

54511

Hôpital d'Adultes; Service hépato-gastro-entérologie, Vandœuvre-lès-Nancy

55131

Uniklinik Mainz; I. Medizinische Klinik, Mainz

56126

Azienda Ospedaliero - Universitaria Pisana U.O. Oncologia Medica 2 Universitaria ? Polo Oncologico, Pisa

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

59037

Hopital Claude Huriez;Gastro Enterologie, Lille

60590

Klinik Johann Wolfgang von Goethe Uni; Zentrum der Inneren Medizin; Medizinische Klinik I, Frankfurt

63110

Washington University; Wash Uni. Sch. Of Med, St Louis

67098

Hopital Hautepierre; Gastro Enterologie, Strasbourg

69317

Hopital De La Croix Rousse; Hepatologie Gastro Enterologie, Lyon

76031

Hopital Charles Nicolle; Gastroenterologie, Rouen

77030

M.D Anderson Cancer Center; Uni of Texas At Houston, Houston

82100

Az. Osp. Rummo; Oncologia Medica, Benevento

85234

Banner MD Anderson Cancer Center, Greeley

85260

St. Josephs Hospital and Medical Center, Phoenix

87102

University of New Mexico Comprehensive Cancer Center, Albuquerque

90404

University of California Los Angeles, Santa Monica

91010

City of Hope, Duarte

92093

Uni of California - San Diego; Cancer Center & Dept of Medicine, La Jolla

92868

University of California Irvine Medical Center, Orange

93053

Klinikum der Uni Regensburg; Klinik f.Innere Medizin I Abt. Hämatologie und Internistische Onkologie, Regensburg

94115

California Pacific Medical Center, San Francisco

94118

Kaiser Permanente - San Francisco Medical Center, San Francisco

94589

Kaiser Permanente Northern California, Novato

94596

Kaiser Permanente - Walnut Creek, Walnut Creek

94805

Institut Gustave Roussy; Gastro-Enterologie, Villejuif

95825

Kaiser Permanente Sacramento Medical Center, Sacramento

98104

Swedish Cancer Inst., Seattle

100032

Peking Union Medical College Hospital, Beijing

100050

Beijing Friendship Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

110016

The 900th Hospital of PLA joint service support force, Fuzhou

115478

"FSBI National Medical Research Center of Oncology N.N. Blokhin?; Clinical Biotechnologies", Moscow

130021

the First Hospital of Jilin University, Changchun

132013

Jilin Cancer Hospital, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

169610

National Cancer Centre, Singapore

197758

GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology), Saint Petersburg

200032

Zhongshan Hospital Fudan University, Shanghai

200120

Fudan University Shanghai Cancer Center, Shanghai

210002

The 81st Hospital of P.L.A., Nanjing

230022

The First Affiliated Hospital of Anhui Medical University, Hefei

230031

Anhui Province Cancer Hospital, Hefei

250031

General Hospital of Jinan Military Command of PLA, Jinan

308433

Tan Tock Seng Hospital; Oncology, Singapore

310003

The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou

310018

Sir Run Run Shaw Hospital, Hangzhou

310022

Zhejiang Cancer Hospital; Zhejiang Cancer Hospital cancer department, Hangzhou

410013

Hunan Cancer Hospital, Changsha

430030

Tongji Hosp, Tongji Med. Col, Huazhong Univ. of Sci. & Tech, Wuhan

510000

The First People's Hospital of Foshan; Local Ethic Committee, Foshan

510515

Nanfang Hospital, Southern Medical University, Guangzhou

510663

Sun Yet-sen University Cancer Center, Guangzhou

02114

Massachusetts General Hospital, Boston

K1Y 4E9

Ottawa Hospital Research Institute, Ottawa

H2X 0A9

Centre hospitalier de l'Universite de Montreal (CHUM), Montreal

H3T 1E2

Jewish General Hospital, Montreal

H4A 3J1

McGill University Health Centre - Glen Site, Montreal

656 53

Masarykuv onkologicky ustav, Brno

779 00

Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc

06202

CHU Nice - Hôpital de l'Archet 2; service Hepato gastro enterologie, Nice

04103

Universitätsklinikum Leipzig Medizinische Klinik II Gastroenterolog. u. Hepatolog., Leipzig

Unknown

Queen Mary Hospital; Dept. Of Haematology & Oncology, Hong Kong

Prince of Wales Hosp; Dept. Of Clinical Onc, Shatin

09100

A.O.U. Cagliari-P.O. Monserrato;U.O. Oncologia, Cagliari

260-8677

Chiba University Hospital, Chiba

277-8577

National Cancer Center Hospital East, Chiba

830-0011

Kurume University Hospital, Fukuoka

060-0033

Sapporo Kosei Genaral Hospital, Hokkaido

060-8648

Hokkaido University Hospital, Hokkaido

920-8641

Kanazawa University Hospital, Ishikawa

252-0375

Kitasato University Hospital, Kanagawa

860-8556

Kumamoto University Hospital, Kumamoto

545-8586

Osaka Metropolitan University Hospital, Osaka

589-8511

Kindai University Hospital, Osaka

840-8571

Saga-ken Medical Centre Koseikan, Saga

411-8777

Shizuoka Cancer Center, Shizuoka

180-8610

Japanese Red Cross Musashino Hospital, Tokyo

80-219

Copernicus Podmiot Medyczny Sp. z o.o. Wojewodzkie Centrum Onkologii, Gdansk

41-400

ID Clinic, Mysłowice

10-228

SP ZOZ MSWiA z WARMINSKO-MAZURSKIM CENTRUM ONKOLOGII; CLINICAL ONCOLOGY, CLINICAL IMMUNOLOGY, Olsztyn

02-781

Narodowy Instytut Onkologii im. Marii Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy, Warsaw

53-413

Dolno?l?skie Centrum Onkologii; Oddzia? Onkologii Klinicznej i Chemioterapii, Wroc?aw

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08035

Hospital Universitari Vall d'Hebron; Oncology, Barcelona

00704

National Cheng Kung University Hospital; Oncology, Tainan City

00112

Veterans General Hospital; Cancer Center, Taipei

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

NW3 2QG

Royal Free Hospital; Dept of Oncology, London

SE5 9RS

King'S College Hospital, London

M2O 4BX

Christie Hospital Nhs Trust; Medical Oncology, Manchester

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03434379 - A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma | Biotech Hunter | Biotech Hunter