1,563
Participants
Start Date
March 7, 2018
Primary Completion Date
May 10, 2022
Study Completion Date
August 24, 2022
Early Vasopressors
"Norepinephrine will be used as preferred vasopressor and titrated to achieve mean arterial pressure (MAP) between 65 mmHg and 75 mmHg. Rescue fluids may be administered as 500ml boluses if predefined rescue criteria are met."
Early Fluids
"Additional 2 liter intravenous fluid infusion upon enrollment (may forego second liter if MAP/SBP and heart rate are normalized and clinical assessment if patient is fluid replete after the first liter). Administer 500ml fluid boluses for fluid triggers until 5 liters administered or development of clinical signs of acute volume overload develop. Rescue vasopressors may be administered after 5 liters of fluid, for development of acute volume overload, or if other predefined rescue criteria are met. Any type of isotonic crystalloid (normal saline, ringers lactate, balanced solution such as plasmalyte) is permitted."
Mt. Sinai Hospital, New York
Montefiore Medical Center, New York
UPMC Mercy, Pittsburgh
UPMC Presbyterian, Pittsburgh
UPMC Shadyside, Pittsburgh
Penn State Hershey Medical Center, Hershey
Temple University Hospital, Philadelphia
University Virginia Medical Center, Charlottesville
VCU Medical Center, Richmond
Wake Forest Baptist Health, Winston-Salem
Duke University Medical Center, Durham
Medical University of South Carolina, Charleston
University of North Carolina at Chapel Hill, Chapel Hill
Vanderbilt University Medical Center, Nashville
University of Mississippi Medical Center, Jackson
University of Kentucky, Lexington
Ohio State University Wexner Medical Center, Columbus
Cleveland Clinic Foundation, Cleveland
University of Cincinnati Medical Center, Cincinnati
Indiana University Health Methodist Hospital, Indianapolis
University of Michigan Medical Center, Ann Arbor
University of Minnesota Medical Center, Minneapolis
Hennepin County Medical Center, Minneapolis
University Medical Center (LSU), New Orleans
University of Texas Health Science Center, Houston
University of Colorado Hospital, Aurora
Denver Health Medical Center, Denver
St. Joseph Hospital, Denver
Intermountain Medical Center, Murray
University of Utah Health Sciences Center, Salt Lake City
LDS Hospital, Salt Lake City
McKay-Dee Hospital, Ogden
Utah Valley Regional Medical Center, Provo
University of Arizona, Tucson
Ronald Reagan UCLA, Los Angeles
UCSF Fresno, Fresno
UCSF San Francisco, San Francisco
Stanford University Hospital, Stanford
Oregon Health and Science University OHSU, Portland
Harborview Medical Center, Seattle
University of Washington Medical Center, Seattle
Swedish Hospital First Hill, Seattle
Yale New Haven Hospital, New Haven
Maine Medical Center, Portland
Massachusetts General Hospital, Boston
Brigham and Women's Hospital, Boston
Beth Israel Medical Center, Boston
Brigham and Women's Hospital, Boston
Baystate Medical Center, Springfield
St. Vincent Hospital, Worcester
Massachusetts General Hospital
OTHER