A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma

PHASE3CompletedINTERVENTIONAL
Enrollment

512

Participants

Timeline

Start Date

January 26, 2018

Primary Completion Date

December 1, 2020

Study Completion Date

December 28, 2022

Conditions
Esophageal Squamous Cell Carcinoma (ESCC)
Interventions
DRUG

Tislelizumab

200 mg administered intravenously (IV)

DRUG

Paclitaxel

135-175 mg /m² administered IV , or 80-100 mg/m\^2 administered IV according to local guidelines for standard of care

DRUG

Docetaxel

75 mg/m\^2 administered IV or 70 mg/m\^2 IV in Japan

DRUG

Irinotecan

125 mg/m\^2 administered IV

Trial Locations (104)

736

Chi Mei Hospital Liouying, Tainan City

1200

Cliniques Universitaires Saint Luc, Brussels

2650

Uz Antwerpen, Edegem

2820

Imelda Ziekenhuis Bonheiden, Bonheiden

3000

University Hospitals Leuven, Leuven

8036

Hospital Clinic de Barcelona, Barcelona

10043

Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano

10126

Ao Citta Della Salute E Della Scienza Di Torino Presidio O, Torino

11217

Taipei Veterans General Hospital, Taipei

13353

Charite Universitatsmedizin Berlin, Berlin

13620

Seoul National University Bundang Hospital, Seongnam-si

21079

Centre Georges Francois Leclerc, Dijon

21565

Gachon University Gil Medical Center, Incheon

25030

Chu Besancon Hopital Jean Minjoz, Doubs

28034

Hospital Universitario Ramon Y Cajal, Madrid

28041

Hospital Universitario de Octubre, Madrid

28050

Hospital Universitario Hm Madrid Sanchinarro, Madrid

29200

Chru de Brest Hospital Morvan, Brest

33600

Chu Bordeaux Hopital Haut Leveque, Pessac

34090

Icm Val Daurelle, Montpellier

40447

China Medical University Hospital, Taichung

43623

Toledo Clinic Cancer Center, Toledo

44805

Ico Site Rene Gauducheau, SaintHerblain

47014

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst, Meldola

48018

Ospedale Di Faenza, Faenza

48202

Henry Ford Hospital, Detroit

50009

Hospital Universitario Miguel Servet, Zaragoza

55131

Klinikum Johannes Gutenberg Universitaet Mainz, Mainz

56126

Aou Pisana, Stabilimento Di Santa Chiara, Pisa

58128

Chonnam National University Hwasun Hospital, HwasunGun

59000

Centre Oscar Lambret, Lille

69008

Hopital Prive Jean Mermoz, Lyon

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

86000

Chu de Poitiers Site de La Mileterie, Poitiers

94805

Institut Gustave Roussy, Villejuif

100050

Beijing Friendship Hospital, Capital Medical University, Beijing

100142

Beijing Cancer Hospital, Beijing

100225

National Taiwan University Hospital East Campus, Taipei

100730

Peking Union Medical College Hospital, Beijing

130021

The First Hospital of Jilin University, Changchun

150000

Harbin Medical University Cancer Hospital, Harbin

200000

Fudan University Shanghai Cancer Center, Shanghai

210008

Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School, Nanjing

210029

Jiangsu Province Hospital, Nanjing

213000

The First Peoples Hospital of Changzhou, Changzhou

221000

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

223002

Huaian Second Peoples Hospital, Huaian

226000

Nantong Tumor Hospital Branch South, Nantong

230601

The Second Hospital of Anhui Medical University, Hefei

250117

Shandong Cancer Hospital, Jinan

261000

Weifang Peoples Hospital, Weifang

276001

Linyi Cancer Hospital, Linyi

310003

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

330029

Jiangxi Province Cancer Hospital, Nanchang

350001

Fujian Medical University Union Hospital, Fuzhou

350005

The First Affiliated Hospital of Fujian Medical University, Fuzhou

350014

Fujian Cancer Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

410013

Hunan Cancer Hospital, Changsha

430079

Hubei Cancer Hospital, Wuhan

441021

Xiangyang Central Hospital, Xiangyang

450000

Henan Cancer Hospital, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

453100

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang

510080

The First Affiliated Hospital, Sun Yat Sen University, Guangzhou

510655

The Sixth Affiliated Hospital, Sun Yat Sen University, Guangzhou

515031

Cancer Hospital of Shantou University Medical College, Shantou

518036

Peking University Shenzhen Hospital, Shenzhen

610071

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu

650100

Yunnan Cancer Hospital, Kunming

710004

The Second Affiliated Hospital of Xian Jiaotong University, Xi'an

6068507

Kyoto University Hospital, Kyoto

071000

Affiliated Hospital of Hebei University, Baoding

030012

Shanxi Provincial Peoples Hospital, Taiyuan

04103

Universitares Krebszentrum Leipzig, Leipzig

010-8543

Akita University Hospital, Akitashi

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

Nho Shikoku Cancer Center, Matsuyama

811-1395

Nho Kyushu Cancer Center, Fukuoka

650-0047

Kobe City Medical Center General Hospital, Kobe

216-8511

St Marianna University School of Medicine Hospital, Yokohama

541-8567

Osaka International Cancer Institute, Osakashi

589-8511

Kindai University Hospital, Sayama

565-0871

Osaka University Hospital, Suitashi

569-8686

Osaka Medical and Pharmaceutical University Hospital, Takatsukishi

362-0806

Saitama Cancer Center, Kitaadachigun

411-8777

Shizuoka Cancer Center, Suntogun

104-0045

National Cancer Center Hospital, Chuoku

135-8550

Cancer Institute Hospital of Jfcr, Kotoku

734-8551

Hiroshima University Hospital, Hiroshima

781-8555

Kochi Health Sciences Center, Kochi

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

08003

Hospital Del Mar, Barcelona

08035

Hospital Universitario Vall Dhebron, Barcelona

08908

Institut Catala Doncologia, Barcelona

M20 4BX

The Christie Hospital, Greater Manchester

SE1 9RT

Guys and St Thomas Hospital Nhs Foundation Trust, London

W1G 6AD

Sarah Cannon Research Institute Uk, London

W2 1NY

St Marys Hospital Imperial College Healthcare Nhs Trust, London

HA6 2RN

Mount Vernon Hospital (Mount Vernon Cancer Center), Northwood

SM2 5PT

Royal Marsden Nhs Foundation Royal Marsden Hospital, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT03430843 - A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma | Biotech Hunter | Biotech Hunter