CANTATA: CB-839 With Cabozantinib vs. Cabozantinib With Placebo in Patients With Metastatic Renal Cell Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

444

Participants

Timeline

Start Date

April 24, 2018

Primary Completion Date

August 31, 2020

Study Completion Date

July 16, 2021

Conditions
Advanced Renal Cell CarcinomaMetastatic Renal Cell Carcinoma
Interventions
DRUG

CB-839

Oral glutaminase inhibitor

DRUG

Cabozantinib

Oral receptor tyrosine kinase inhibitor

DRUG

Placebo

Placebo tablets

Trial Locations (133)

1023

Auckland City Hospital, Auckland

2050

Chris O'Brien Lifehouse, Camperdown

2109

MacQuarie University Hospital, North Ryde

2170

Liverpool Hospital, Sydney

2485

Tweed Hospital, Tweed Heads

2576

Southern Highlands Private Hospital (Cancer Centre), Bowral

3144

Cabrini Hospital, Malvern

3199

Peninsula Private Hospital, Frankston

3240

Waikato Hospital, Hamilton

3350

Ballarat Health Services, Ballarat

3630

Goulburn Valley Health, Shepparton

4101

Mater Misericordiae Limited - Division of Cancer Services, South Brisbane

4102

Princess Alexandra Hospital, Woolloongabba

4217

Pindara Private Hospital, Benowa

4870

Cairns Hospital, Cairns

6009

Hollywood Private Hospital, Nedlands

6021

Wellington Regional Hospital, Wellington

8011

Christchurch Hospital, Christchurch

10043

Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano

10117

Charité Universitätsmedizin Berlin, Dept. of Interdisciplinary Urology, Berlin

10549

Northern Westchester Hospital, Mount Kisco

11501

NYU Winthrop Hospital, Mineola

11733

North Shore Hematology Oncology Associates PC dba NY Cancer and Blood Specialists, East Setauket

11794

Stony Brook Cancer Center, Stony Brook

13009

Institut Paoli-Calmettes Service d'Urologie, Marseille

14076

Centre François Baclesse, Caen

14263

Roswell Park Cancer Center, Buffalo

15212

Allegheny General Hospital, Pittsburgh

15232

University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh

17007

Institut Català d'Oncologia, Girona

19111

Fox Chase Cancer Center, Philadelphia

20007

Georgetown University Medical Center, Washington D.C.

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20141

Istituto Europeo di Oncologia - Divisione di Oncologia Medica Urogenitale e Cervico Facciale, Milan

20153

U.O.C. ASST Santi Paolo e Carlo - Ospedale San Carlo Borromeo, Milan

21079

Centre Georges-François Leclerc, Dijon

21201

University of Maryland, Greenebaum Comprehensive Cancer Center, Baltimore

25030

Centre hospitalier régional universitaire (CHRU) de Besançon - Jean-Minjoz, Besançon

26100

S.C. Oncologia - ASST Cremona P.O. Ospedale di Cremona, Cremona

27100

Unità Operativa (UO) di Oncologia Medica - ICS Maugeri, Pavia

27710

Duke University Medical Center, Durham

28009

HGU Gregorio Marañon, Madrid

28033

MD Anderson Cancer Center Madrid, Madrid

28041

El Hospital Universitario 12 de Octubre, Madrid

28050

Centro Integral Oncologico Clara Campal (CIOCC) HM, Madrid

28204

Levine Cancer Institute, Charlotte

29425

Medical University of South Carolina, Charleston

29607

Saint Francis Hospital Cancer Center, Greenville

30060

Northwest Georgia Oncology Centers, PC, Marietta

30322

Emory Winship Cancer Institute, Atlanta

30625

Medizinische Hochschule Hannover, Hanover

30912

Georgia Cancer Center at Augusta University, Augusta

31059

IUCTO Bureau des Essais Cliniques (Institut Claudius Regaud), Toulouse

33000

CHU de Bordeaux Hôpital Saint André, Bordeaux

33136

University of Miami Sylvester Comprehensive Cancer Center, Miami

33612

H.Lee Moffitt Cancer & Research Institute (Moffitt Cancer Center), Tampa

33705

Florida Cancer Specialists, St. Petersburg

33901

Florida Cancer Specialists, Fort Myers

34298

Institut de Cancérologie de Montpellier (ICM), Montpellier

35294

University of Alabama at Birmingham, Birmingham

37203

The Sarah Cannon Research Institute, Nashville

37232

Vanderbilt University Medical Center, Nashville

38138

West Cancer Center, Germantown

39216

University of Mississippi Medical Center, Jackson

39401

Hattiesburg Clinic Hematology/Oncology, Hattiesburg

41009

Hospital Universitario Virgen de Macarena, Seville

41013

Hospital Universitario Virgen del Rocío, Seville

41124

University of Modena and Reggio Emilia (Azienda Ospedaliera-Universitaria Policlinico Modena), Modena

44805

Institut de Cancérologie de l'Ouest (ICO) - Centre René Gauducheau, Saint-Herblain

45147

Universitätsklinikum Essen (AöR) Westdeutsches Tumorzentrum, Essen

46009

Fundación Instituto Valencia d'Oncología (IVO), Valencia

46526

Goshen Center for Cancer Care, Goshen

47923

U.O. Oncologia Ospedale degli Infermi - Dipartimento di Oncologia ed Ematologia, Rimini

48201

Karmanos Cancer Institute, Detroit

53226

Froedtert Hospital and the Medical College of Wisconsin, Milwaukee

55101

HealthPartners Institute, Regions Cancer Care Center, Saint Paul

60077

Orchard Healthcare Research, Inc., Skokie

60201

NorthShore University HealthSystem, Evanston

60521

AMITA Health Cancer Institute & Outpatient Center, Hinsdale

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60637

University of Chicago, Chicago

63011

Centre Jean Perrin, Clermont-Ferrand

64132

HCA Midwest Health, Kansas City

64804

Mercy Hospital, Joplin

67091

CHU de Strasbourg (Les Hôpitaux Universitaires de Strasbourg), Strasbourg

69008

Centre Léon Bérard, Lyon

69120

Medical University Heidelberg, NCT (National Center for Tumour Diseases), Medical Oncology, Heidelberg

70006

East Jefferson General Hospital, Metairie

70121

Ochsner Clinic Foundation, New Orleans

72076

Universitätsklinikum Tübingen, Klinik für Urologie, Tübingen

72100

Presidio Ospedaliero Antonio Perrino - U.O.C. Oncologia Medica, Brindisi

73142

INTEGRIS Cancer Institute of Oklahoma Proton Campus, Oklahoma City

75015

Hôpital Européen Georges-Pompidou (HEGP), Paris

76104

The Center for Cancer and Blood Disorders, Fort Worth

77030

The University of Texas MD Anderson Cancer Center, Houston

80131

"Istituto Nazionale Tumori IRCCS Fondazione G. Pascale", Naples

80907

Penrose Cancer Center, Research Department, Colorado Springs

81675

Technischen Universitat München - Urologische Klinik, München

83712

St. Luke's Mountain States Tumor Institute, Boise

84112

University of Utah, Huntsman Cancer Institute, Salt Lake City

85054

Mayo Clinic Cancer Center, Phoenix

85724

The University of Arizona Cancer Center, Tucson

87401

San Juan Oncology Associates, PC, Farmington

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

90048

Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles

93901

Salinas Valley Memorial Healthcare System, Salinas

94010

Centre hospitalier universitaire (CHU) Henri-Mondor, Créteil

94304

Stanford Cancer Center, Palo Alto

94805

Institut Gustave Roussy - Le département de Medecine oncologique, Villejuif

95403

St. Joseph Heritage Healthcare, Santa Rosa

99336

Kadlec Clinic Hematology and Oncology, Kennewick

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

06189 Nice Cedex 2

Centre Antoine Lacassagne, Nice

CS 30519 54519

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

01307

Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Klinik und Poliklinik, Dresden

00168

Policlinico Universitario A. Gemelli, Roma

00128

Policlinico Universitario Campus Bio-Medico, Rome

08035

Hospital Universitari VHIO - Vall d'Hebron Departamento de Oncologia, Barcelona

08036

El Hospital Clínic i Provincial de Barcelona (HCPB), Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

08908

Institut Català d'Oncologia (ICO) L'Hospitalet, Barcelona

08208

Hospital Parc Taulí de Sabadell, Sabadell

M20 4BX

The Christie NHS Foundation Trust, Manchester

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

HA6 2RN

Mount Vernon Cancer Centre, London

NG5 1PB

Nottingham University Hospitals NHS Trust - City Hospital Campus, Nottingham

EC1A7BE

St. Bartholomew's Hospital, Barts Health NHS Trust, London

SW3 6JJ

The Royal Marsden NHS Foundation Trust, London

W1G 6AD

Sarah Cannon Research Institute UK Limited, London

SO16 6YD

Southampton General Hospital, Southampton

Sponsors
All Listed Sponsors
lead

Calithera Biosciences, Inc

INDUSTRY

NCT03428217 - CANTATA: CB-839 With Cabozantinib vs. Cabozantinib With Placebo in Patients With Metastatic Renal Cell Carcinoma | Biotech Hunter | Biotech Hunter