797
Participants
Start Date
April 24, 2018
Primary Completion Date
July 10, 2023
Study Completion Date
June 29, 2026
Pembrolizumab
200 mg by IV infusion every 3 weeks (Q3W), given on cycle day 1.
Placebo
Normal saline by IV infusion Q3W, given on cycle day 1.
Cisplatin
75 mg/m\^2 by IV infusion Q3W, given on cycle day 1.
Gemcitabine
1000 mg/m\^2 by IV infusion Q3W, given on cycle days 1 and 8. Given only to participants with squamous NSCLC.
Pemetrexed
500 mg/m\^2 by IV infusion Q3W, given on cycle day 1. Given only to participants with nonsquamous NSCLC.
Taipei Veterans General Hospital ( Site 0722), Taipei
Tri-Service General Hospital ( Site 0726), Taipei
Chang Gung Medical Foundation.Linkou Branch ( Site 0723), Taoyuan District
Pauls Stradins Clinical University Hospital ( Site 0911), Riga
Riga East Clinical University Hospital ( Site 0912), Riga
Westmead Hospital ( Site 0621), Westmead
Wits Clinical Research ( Site 0570), Parktown-Johannesburg
Orange Health Services ( Site 0624), Orange
AZ Sint-Maarten ( Site 0226), Mechelen
UZ Leuven ( Site 0221), Leuven
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0223), Liège
The Oncology Centre ( Site 0571), Durban
Hospital Privado Universitario de Córdoba ( Site 0139), Córdoba
Cape Town Oncology Trials Pty Ltd ( Site 0572), Kraaifontein
AZ Delta ( Site 0222), Roeselare
UZ Gent ( Site 0224), Ghent
AZ Nikolaas ( Site 0225), Sint-Niklaas
AOU San Luigi Gonzaga di Orbassano ( Site 0313), Orbassano
National Taiwan University Hospital ( Site 0721), Taipei
Memorial Sloan Kettering Cancer Center ( Site 0060), New York
National Cancer Center ( Site 0702), Gyeonggi-do
Montefiore Einstein Center ( Site 0016), The Bronx
White Plains Hospital Center for Cancer Care ( Site 0007), White Plains
Memorial Sloan Kettering Cancer Center Westchester ( Site 0079), Harrison
Memorial Sloan Kettering Cancer Center - Nassau ( Site 0078), Uniondale
Memorial Sloan-Kettering Cancer Center at Commack ( Site 0076), Commack
St. Peter's Hospital Cancer Care Center ( Site 0039), Albany
Evangelische Lungenklinik Berlin ( Site 0274), Berlin
SA Pohja-Eesti Regionaalhaigla ( Site 1100), Tallinn
HELIOS Klinikum Emil von Behring ( Site 0280), Berlin
Allegheny General Hospital ( Site 0009), Pittsburgh
UPMC Hillman Cancer Centers ( Site 0041), Pittsburgh
VA Pittsburgh Healthcare System ( Site 0052), Pittsburgh
The Catholic University of Korea St. Vincent s Hospital ( Site 0705), Gyeonggi-do
Hospital Universitario de Girona Doctor Josep Trueta ( Site 0386), Girona
UPMC Pinnacle Health System - East Location ( Site 0063), Harrisburg
Cherkassy Regional Oncological Center ( Site 0613), Cherkasy
Cancer Treatment Centers of America-Eastern Regional Medical Center ( Site 0053), Philadelphia
Helen F. Graham Cancer Center & Research Institute ( Site 0015), Newark
Istituto Clinico Humanitas Research Hospital ( Site 0314), Rozzano
IRCCS Ospedale San Raffaele di Milano ( Site 0303), Milan
Istituto Nazionale Tumori ( Site 0309), Milano
ASST Grande Ospedale Metropolitano Niguarda-Oncologia Falck ( Site 0315), Milan
Azienda Ospedaliera San Gerardo ( Site 0308), Monza
Asklepios Klinikum Hamburg ( Site 0271), Hamburg
Harry & Jeanette Weinberg Cancer Institute ( Site 0081), Baltimore
Inova Schar Cancer Institute ( Site 0032), Fairfax
Virginia Cancer Specialists, PC ( Site 0080), Fairfax
Emily Couric Clinical Cancer Center ( Site 0013), Charlottesville
LungenClinic Grosshansdorf GmbH ( Site 0267), Großhansdorf
Universitaetsklinikum Schleswig Holstein ( Site 0871), Kiel
PP PPC Acinus Medical and Diagnostic Centre ( Site 0609), Kropyvnytsky
Azienda Ospedaliera Spedali Civili di Brescia ( Site 0307), Brescia
Hospital General Universitario Gregorio Maranon ( Site 0382), Madrid
Saint Francis Cancer Center ( Site 0096), Greenville
Southeastern Regional Medical Center ( Site 0051), Newnan
CHU de Toulouse - Hopital Larrey ( Site 0258), Toulouse
Mayo Clinic Jacksonville ( Site 0022), Jacksonville
Miami Cancer Institute-Baptist Hospital ( Site 0068), Miami
LKI Lungenfachklinik Immenhausen ( Site 0268), Immenhausen
Hospital Universitario Insular de Gran Canaria ( Site 0383), Las Palmas de Gran Canaria
China Medical University Hospital ( Site 0724), Taichung
Florence Nightingale Krankenhaus ( Site 0874), Düsseldorf
Hospital Virgen del Rocio ( Site 0387), Seville
Ashland-Bellefonte Cancer Center ( Site 0021), Ashland
PPG-Oncology ( Site 0043), Fort Wayne
IRST-Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori ( Site 0300), Meldola
Henry Ford Health System ( Site 0031), Detroit
Mathias Spital Rheine ( Site 0261), Rheine
Herbert Herman Cancer Center, Sparrow Hospital ( Site 0034), Lansing
City Clinical Hosp.4 of DCC ( Site 0607), Dnipro
LSMUL Kauno Klinikos ( Site 0932), Kaunas
University of Iowa Hospital and Clinics ( Site 0010), Iowa City
Mayo Clinic ( Site 0026), Rochester
Katholisches Klinikum Koblenz Haus Marienhof ( Site 0873), Koblenz
Lungenklinik Hemer ( Site 0269), Hemer
University Malaya Medical Centre ( Site 0781), Kuala Lumpur
St. Vincent Healthcare Frontier Cancer Center ( Site 0005), Billings
Northwest Oncology and Hematology ( Site 0001), Elk Grove Village
Ingalls Memorial Hospital ( Site 0044), Harvey
MI Odessa Regional Oncological Centre ( Site 0608), Odesa
Nouvel Hopital Civil ( Site 0255), Strasbourg
Zaporizhzhya Regional Clinical Oncology Center ( Site 0606), Zaporizhzhya
Hospices Civils de Lyon Centre Hospitalier Lyon Sud ( Site 0241), Pierre-Bénite
MI KhRC Kherson Regional Oncology Dispensary ( Site 0614), Kherson
Centre Hospitalier Metropole Savoie Site de Chambery ( Site 0245), Chambéry
Klinikum Esslingen GmbH ( Site 0875), Esslingen am Neckar
Southwestern Regional Medical Center, Inc. ( Site 0054), Tulsa
Centre Hospitalier Annecy Genevois ( Site 0242), Pringy
Institut Curie ( Site 0250), Paris
MI Precarpathian Clinical Oncology Center ( Site 0603), Ivano-Frankivsk
CHU de Rouen ( Site 0252), Rouen
Azienda Ospedaliera dei Colli V. Monaldi ( Site 0301), Napoli
Kaohsiung Chang Gung Memorial Hospital ( Site 0725), Kaohsiung City
H.I.A. Sainte-Anne ( Site 0251), Toulon
University of Arizona Cancer Center - Dignity Health ( Site 0062), Phoenix
Banner MD Anderson Cancer Center ( Site 0028), Gilbert
Western Regional Medical Center, Inc. ( Site 0050), Goodyear
University of Arizona Cancer Center ( Site 0012), Tucson
Clinique Francois Chenieux ( Site 0246), Limoges
John Wayne Cancer Institute ( Site 0049), Santa Monica
Providence Saint Joseph Medical Center ( Site 0061), Burbank
Hopital Foch ( Site 0243), Suresnes
Pacific Cancer Medical Center, Inc. ( Site 0004), Anaheim
Hôpital Avicenne - Service d oncologie medicale ( Site 0249), Bobigny
Sarawak General Hospital ( Site 0782), Kuching
Pacific Cancer Care ( Site 0035), Monterey
Stanford University, Stanford Cancer Center ( Site 0046), Stanford
St Joseph Heritage Healthcare ( Site 0040), Santa Rosa
OHSU Center for Health & Healing ( Site 1006), Portland
Providence Regional Cancer Partnership ( Site 0065), Everett
Zentralklinik Bad Berka GmbH ( Site 0264), Bad Berka
Beijing Cancer Hospital ( Site 0810), Beijing
Beijing Cancer Hospital ( Site 0811), Beijing
Cancer Hospital Chinese Academy of Medical Sciences ( Site 0801), Beijing
Peking University Third Hospital ( Site 0812), Beijing
Peking Union Medical College Hospital ( Site 0809), Beijing
N.N. Blokhin NMRCO ( Site 0521), Moscow
National Medical Research Radiology Centre ( Site 0535), Moscow
Medical Rehabilitation Center ( Site 0534), Moscow
SBHI Leningrad Regional Clinical Hospital ( Site 0524), Saint Petersburg
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0533), Saint Petersburg
Municipal Clinical Oncology Center ( Site 0523), Saint Petersburg
Fudan University Shanghai Cancer Center ( Site 0813), Shanghai
Zhongshan Hospital of Fudan University ( Site 0808), Shanghai
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 0504), Craiova
Shanghai Pulmonary Hospital-Thoracic Surgery department ( Site 0817), Shanghai
Tianjin Medical University General Hospital ( Site 0806), Tianjin
S C Oncocenter Oncologie Medicala S R L ( Site 0505), Timișoara
The First Affiliated Hospital of Zhejiang University ( Site 0804), Hangzhou
Zhejiang Cancer Hospital.... ( Site 0814), Hangzhou
Hwa Mei Hospital University of Chinese Academy of Sciences ( Site 0802), Ningbo
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0501), Cluj-Napoca
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0515), Cluj-Napoca
SC Radiotherapy Center Cluj SRL ( Site 0509), Comuna Floresti
Hunan Cancer Hospital ( Site 0815), Changsha
S C Pelican Impex SRL ( Site 0506), Oradea
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 0529), Kazan'
Chelyabinsk Regional Clinical Oncological Dispensary ( Site 0530), Chelyabinsk
Spitalul Sf. Constantin ( Site 0512), Brasov
Sun Yat-Sen University Cancer Center ( Site 0816), Guangzhou
Tomsk Scientific Research Institute of Oncology ( Site 0526), Tomsk
Tang Du Hospital ( Site 0803), Xi’an
Spitalul Judetean de Urgenta .Sf. Ioan cel Nou. ( Site 0503), Suceava
Spitalul clinic Judetean de urgenta Constanta ( Site 0508), Constanța
Hartford Hospital ( Site 0069), Hartford
Boston Medical Center ( Site 0057), Boston
UMass Memorial Medical Center ( Site 0030), Worcester
University of Nebraska Medical Center ( Site 0047), Omaha
Memorial Sloan Kettering Cancer Center Basking Ridge ( Site 0074), Basking Ridge
Memorial Sloan Kettering Cancer Center- Monmouth ( Site 0077), Middletown
MSKCC-Bergen ( Site 0075), Montvale
Stony Brook University Medical Center - Cancer Center ( Site 0019), Stony Brook
Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0136), Berazategui
Hospital Privado de Comunidad. ( Site 0130), Mar del Plata
Hospital Universitario Austral ( Site 0127), Pilar
Fundacion Favaloro ( Site 0128), Ciudad de Buenos Aires
Sanatorio Britanico ( Site 0125), Rosario
Sanatorio Parque ( Site 0135), Rosario
Hospital Provincial del Centenario ( Site 0131), Rosario
Sanatorio Allende ( Site 0129), Córdoba
CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica ( Site 0133), San Juan
Centro Regional Integrado de Oncologia ( Site 0160), Fortaleza
Instituto do Cancer do Ceara ( Site 0152), Fortaleza
Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul ( Site 0159), Brasília
Liga Norte Riograndense Contra o Cancer ( Site 0150), Natal
Hospital de Caridade de Ijui ( Site 0153), Ijuí
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0146), Porto Alegre
Hospital Nossa Senhora da Conceicao ( Site 0145), Porto Alegre
YNOVA Pesquisa Clinica ( Site 0823), Florianópolis
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0144), Barretos
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0149), Rio de Janeiro
Hospital Paulistano - Amil Clinical Research ( Site 0822), São Paulo
Hospital Alemao Oswaldo Cruz ( Site 0158), São Paulo
Princess Margaret Cancer Centre ( Site 0109), Toronto
CIUSSS du Saguenay-Lac-St-Jean ( Site 0101), Chicoutimi
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0110), Montreal
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0104), Montreal
McGill University Health Centre ( Site 0111), Montreal
Universitaetsklinikum Carl Gustav Carus ( Site 0273), Dresden
Universitaetsklinikum Leipzig AOeR ( Site 0277), Leipzig
SRH Waldklinikum Gera GmbH ( Site 0272), Gera
Cork University Hospital ( Site 0452), Wilton
St James Hospital ( Site 0451), Dublin
Mid Western Cancer Centre ( Site 0450), Limerick
Azienda Ospedaliera San Camillo Forlanini ( Site 0311), Roma
Aichi Cancer Center Hospital ( Site 0765), Nagoya
National Cancer Center Hospital East ( Site 0761), Kashiwa
HP of the Univ. of Occupational and Environmental Health, Japan ( Site 0770), Kitakyushu
Hyogo Cancer Center ( Site 0764), Akashi
St. Marianna University School of Medicine Hospital ( Site 0769), Kawasaki
Kanagawa Cancer Center ( Site 0763), Yokohama
Oita University Hospital ( Site 0766), Yufu
Fukushima Medical University Hospital ( Site 0772), Fukushima
Hiroshima University Hospital ( Site 0762), Hiroshima
National Cancer Center Hospital ( Site 0767), Tokyo
Juntendo University Hospital ( Site 0768), Tokyo
Tokyo Medical University Hospital ( Site 0771), Tokyo
Nacionalinis Vezio Institutas ( Site 0931), Vilnius
Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 0487), Poznan
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 0488), Bydgoszcz
Centrum Pulmonologii i Torakochirurgii w Bystrej ( Site 0484), Bystra
Dolnoslaskie Centrum Onkologii. ( Site 0491), Wroclaw
Szpital Specjalistyczny w Prabutach Sp. z o.o. ( Site 0483), Prabuty
Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi ( Site 0493), Lodz
Centrul Medical Medicover Victoria ( Site 0514), Bucharest
S.C.R.T.C.Radiology Therapeutic Center SRL ( Site 0511), Otopeni
Euroclinic Hospital Bucharest ( Site 0510), Bucharest
S.C.Focus Lab Plus S.R.L ( Site 0513), Bucharest
Wilgers Oncology Centre ( Site 0573), Pretoria
Asan Medical Center ( Site 0701), Seoul
Samsung Medical Center ( Site 0704), Seoul
SMG-SNU Boramae Medical Center ( Site 0707), Seoul
Hospital Germans Trias i Pujol. ICO de Badalona ( Site 0381), Badalona
Instituto Catalan de Oncologia - ICO ( Site 0388), L'Hospitalet de Llobregat
Hospital de la Santa Creu i Sant Pau ( Site 0385), Barcelona
Hospital Universitari Vall d Hebron ( Site 0389), Barcelona
National Cancer Institute of the MoH of Ukraine ( Site 0605), Kyiv
Kyiv City Clinical Oncological Center ( Site 0601), Kyiv
Leicester Royal Infirmary ( Site 0447), Leicester
The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0456), Metropolitan Borough of Wirral
Royal Marsden NHS Foundation Trust ( Site 0458), London
Royal Marsden Hospital ( Site 0457), Sutton
Nottingham City Hospital Campus ( Site 0441), Nottingham
Heartlands Hospital in Birmingham ( Site 0455), Birmingham
Freeman Hospital ( Site 0444), Newcastle upon Tyne
Plymouth Hospitals NHS Trust ( Site 0443), Plymouth
Merck Sharp & Dohme LLC
INDUSTRY