Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence

NACompletedINTERVENTIONAL
Enrollment

113

Participants

Timeline

Start Date

May 24, 2018

Primary Completion Date

March 23, 2023

Study Completion Date

March 23, 2023

Conditions
Pierre Robin SequenceBrainstem Dysfunction
Interventions
OTHER

Recording of data

"Recording during one hospitalization of 48 hours between birth and 2 months of life and one hospitalization of 24 hours between 6 and 10 months of life~* General data: age, term of birth, birth weight, gender, diseases, weight and size at recording, cranial perimeter, food, drugs : first and second visit~* Respiratory rate, respiratory signs, stridor : first and second visit~* 24h holter-ECG : first and second visit~* 24h impedance pH-metry : first visit~* Nocturne polysomnography : 50% prone position, 50% supine : sleep analyze, obstructive apnea hypopnea index (OAHI), central apnea index (CAI), periodical breathing, micro arousals index, non-nutritive swallowing analyze,(mental region electromyogram) : first and second visit~* 24 h gaz exchanges : mean, maximal PtcCO2 and % of time spent above 50 mmHg , SpO2 under 90%, 85% et 80% and desaturations index : first and second visit~* succimetry procedure : at first visit only between birth and 2 months"

OTHER

Recording of data

"Recording during one hospitalization of 48 hours between birth and 2 months of life~* General data: age, term of birth, birth weight, gender, diseases, weight and size at recording, cranial perimeter, food, drugs~* Respiratory rate, respiratory signs, stridor~* 24h holter-ECG~* 24h impedance pH-metry~* Nocturne polysomnography : 100% supine position : sleep analyze, obstructive apnea hypopnea index (OAHI), central apnea index (CAI), periodical breathing, micro arousals index, non-nutritive swallowing analyze,(mental region electromyogram)~* 24 h gas exchanges : mean, maximal PtcCO2 and % of time spent above 50 mmHg , SpO2 under 90%, 85% et 80% and desaturations index~* Succimetry procedure : at first visit only between birth and 2 months"

Trial Locations (2)

69500

Hopital Femme Mère Enfant, Bron

75015 Paris

APHP-Necker, Paris

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER

NCT03423017 - Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence | Biotech Hunter | Biotech Hunter