265
Participants
Start Date
April 26, 2018
Primary Completion Date
August 12, 2020
Study Completion Date
April 18, 2024
Daratumumab
Daratumumab will be administered at a dose of 1800 mg by SC injection in Cycles 1 to 4 in D-VRd cohort and until documented progression of disease, unacceptable toxicity, or end of study for D-VMP, D-Rd and D-Kd cohorts.
Bortezomib
Bortezomib will be administered as 1.3 mg/m\^2 SC injection in Cycles 1 to 4 in D-VRd cohort and in Cycles 1 to 9 in D-VMP cohort.
Lenalidomide
Lenalidomide will be administered as 25 mg capsule orally in Cycles 1 to 4 in D-VRd cohort and in all Cycles until documented progression of disease, unacceptable toxicity, or end of study in D-Rd cohort.
Dexamethasone
Dexamethasone will be administered as 20 mg orally or intravenously in Cycles 1 to 4 in D-VRd cohort; 40 mg orally or intravenously in all cycles and thereafter until documented progression of disease, unacceptable toxicity, or end of study in D-Rd and D-Kd cohort.
Melphalan
Melphalan will be administered as 9 mg/m\^2 orally in Cycles 1 to 9.
Prednisone
Prednisone will be administered as 60 mg/m\^2 orally in cycles 1 to 9.
Carfilzomib
Carfilzomib will be administered as 20 mg/m\^2 IV on Day 1 of Cycle 1 only then 70 mg/m\^2 IV on Days 8 and 15 of Cycle 1 and Days 1, 8 and 15 of Cycle 2 and thereafter until documented progression of disease, unacceptable toxicity, or end of study in D-Kd cohort.
Hosp Univ Vall D Hebron, Barcelona
Mt. Sinai School of Medicine, New York
NYU Winthrop, Mineola
Universitaetsklinikum Hamburg Eppendorf, Hamburg
Galilee Medical Center, Nahariya
Asklepios Klinik Altona, Hamburg
University of Virginia Cancer Center - Emily Couric Clinical Cancer Center - Women's Oncology Clinic, Charlottesville
Wake Forest University Baptist Medical Center (WFUBMC) - Comprehensive Cancer Center, Winston-Salem
Hosp. Gral. Univ. Gregorio Maranon, Madrid
Clinica Univ. de Navarra, Madrid
Hosp. Univ. Ramon Y Cajal, Madrid
Hosp. Univ. 12 de Octubre, Madrid
Clinica Univ. de Navarra, Pamplona
Rambam Medical Center, Haifa
Mayo Clinic in Florida, Jacksonville
UF Health Cancer Center at Orlando Health, Orlando
CHU de Bordeaux - Hospital Haut-Leveque, Pessac
Hosp Clinico Univ de Salamanca, Salamanca
CHU Bretonneau, Tours
CHU de Nantes hotel Dieu, Nantes
Hosp. Univ. Dr. Peset, Valencia
Providence Cancer Center, Southfield
Karmonos Cancer Institute, Detroit
Sheba Medical Center, Ramat Gan
CHU Nancy Brabois, Vandœuvre-lès-Nancy
Avera Medical Group - Oncology & Hematology, Sioux Falls
Billings Clinic, Billings
Tel Aviv Sourasky Medical Center, Tel Aviv
Nebraska Cancer Specialists, Omaha
Nebraska Hematology and Oncology, Lincoln
Southeast Nebraska Cancer Center, Lincoln
Universitaetsklinikum Heidelberg, Heidelberg
Centre hospitalier Lyon-Sud, Pierre-Bénite
Fakultni Nemocnice Ostrava, Ostrava
Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,, Tübingen
Utah Cancer Specialists, Salt Lake City
San Juan Oncology Associates, Farmington
Carmel Medical Center, Haifa
Hadassah Medical Center, Jerusalem
Cancer Center of Central Connecticut - Southington, Southington
Liga Norte Riograndense Contra O Cancer, Natal
Associacao Hospitalar Beneficente Sao Vicente de Paulo - Hospital Sao Vicente de Paulo, Passo Fundo
Ministerio da Saude Instituto Nacional do Cancer, Rio de Janeiro
Clinica Sao Germano, São Paulo
SPDM - Associacao Paulista para o Desenvolvimento da Medicina - Hospital Sao Paulo, São Paulo
Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE, São Paulo
Fakultni nemocnice Brno, Brno
Fakultni nemocnice Hradec Kralove, Hradec Králové
Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie, Prague
Klinikum Chemnitz gGmbH, Chemnitz
Kanazawa University Hospital, Kanazawa
Matsuyama Red Cross Hospital, Matsuyama
Nagoya City University Hospital, Nagoya
Japanese Red Cross Medical Center, Shibuya City
Inst. Cat. D'Oncologia-Badalona, Badalona
Hosp Clinic de Barcelona, Barcelona
Inst. Cat. Doncologia-H Duran I Reynals, Barcelona
Hosp. Son Llatzer, Mallorca
Heart of England NHS Foundation Trust, Birmingham
Royal Bournemouth Hospital, Bournemouth
Kent and Canterbury Hospital, Canterbury
Manchester Royal Infirmary, Manchester
Derriford Hospital, Plymouth
Royal Stoke University Hospital, Stoke-on-Trent
Janssen Research & Development, LLC
INDUSTRY