MesoTRAP: A Study Comparing Video-assisted Thoracoscopic Partial Pleurectomy/Decortication With Indwelling Pleural Catheter in Patients With Trapped Lung Due to Malignant Pleural Mesothelioma.

NACompletedINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

August 10, 2017

Primary Completion Date

March 31, 2020

Study Completion Date

August 1, 2020

Conditions
Malignant Pleural MesotheliomaTrapped Lung
Interventions
PROCEDURE

pleurectomy/decortication

"VAT-PD is a type of keyhole surgery performed under general anaesthesia using a telescope and instruments put inside the chest. Through small incisions, or keyholes made between the ribs, the thoracic surgeon removes the hard rind of the tumour over the surface of the lung, thereby allowing the 'trapped' lung to fully expand again. Simultaneous removal of mesothelioma from the outer pleural membrane allows pleurodesis to occur."

PROCEDURE

indwelling pleural catheter

A soft silicone catheter (IPC) with a one-way valve at the end is inserted a few centimetres under the skin under local anaesthesia. The inside end of the catheter is inserted into the pleural space and the outside end is connected to a vacuum drainage bottle. The IPC permits regular fluid drainage.

Trial Locations (18)

Unknown

Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool

North Bristol NHS Trust, Bristol

Cambridge University Hospitals, Cambridge

Derby Teaching Hospitals NHS Foundation Trust, Derby

Golden Jubilee National Hospital, Glasgow

Queen Elizabeth University Hospital and New Victoria Hospital, Glasgow

University Hospitals of Leicester, Leicester

Barts Health NHS Trust, London

Manchester University NHS Foundation Trust, Manchester

Pennine Acute Hospitals NHS Trust, Manchester

Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich

Nottingham University Hospitals NHS Trust, Nottingham

Oxford University Hospitals, Oxford

North West Anglia NHS Foundation Trust, Peterborough

Lancashire Teaching Hospitals NHS Foundation Trust, Preston

Sheffield Teaching Hospitals, Sheffield

University Hospitals of North Midlands NHS Trust, Stoke-on-Trent

CB23 5EF

Papworth Hospital NHS Foundation Trust, Cambridge

All Listed Sponsors
collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

collaborator

London School of Hygiene and Tropical Medicine

OTHER

collaborator

King's College London

OTHER

collaborator

University of Sheffield

OTHER

lead

Papworth Hospital NHS Foundation Trust

OTHER_GOV

NCT03412357 - MesoTRAP: A Study Comparing Video-assisted Thoracoscopic Partial Pleurectomy/Decortication With Indwelling Pleural Catheter in Patients With Trapped Lung Due to Malignant Pleural Mesothelioma. | Biotech Hunter | Biotech Hunter