500
Participants
Start Date
March 11, 2019
Primary Completion Date
September 30, 2026
Study Completion Date
December 31, 2026
Hydrocortisone, sodium succinate
Patients randomized to the hydrocortisone treatment arm will receive an initial bolus of 2 mg/kg IV hydrocortisone, followed by 1 mg/kg (maximum 50 mg) of hydrocortisone dosed every six hours for a maximum of seven days or until all vasoactive infusions have been discontinued for at least 12 hours, whichever comes first. When the hydrocortisone course is completed, the medication will be discontinued.
Normal saline
Patients randomized to the placebo treatment arm will receive an equivalent volume of normal saline, with the identical dosing schedule to the intervention (hydrocortisone) arm.
RECRUITING
Penn State Milton S. Hershey Children's Hospital, Hershey
RECRUITING
Nemours Children's Health, Wilmington
NOT_YET_RECRUITING
Le Bonheur Children's Hospital, Memphis
RECRUITING
University of Louisville, Norton Children's Hospital, Louisville
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
University of Wisconsin Health/American Family Children's Hospital, Madison
RECRUITING
University of Chicago, Comer Children's Hospital, Chicago
RECRUITING
The University of Illinois at Chicago/OSF Children's Hospital of Illinois, Peoria
RECRUITING
The Children's Hospital at Oklahoma University Medical Center, Oklahoma City
RECRUITING
Primary Children's Hospital, Salt Lake City
RECRUITING
University of Arizona Medical Centre, Tucson
RECRUITING
Children's Hospital of Los Angeles, Los Angeles
RECRUITING
Children's Hospital of Orange County, Orange
RECRUITING
UCSF Benioff Children's Hospital - San Francisco, San Francisco
RECRUITING
UCSF Benioff Children's Hospital - Oakland, Oakland
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Boston Children's Hospital, Boston
RECRUITING
Saint Barnabas Medical Center, Livingston
RECRUITING
Santa Casa de Misericordia Da Bahia, Bahia
RECRUITING
Hospital Jutta Batista - Rio de Janeiro, Rio de Janeiro
NOT_YET_RECRUITING
Rambam Health Care Campus, Haifa
NOT_YET_RECRUITING
Hadassah University Medical Center, Ein Kerem, Jerusalem
NOT_YET_RECRUITING
Schneider Children's Medical Center of Israel, Petah Tikva
RECRUITING
Kobe Children's Hospital, Kobe
RECRUITING
Aichi Children's Health and Medical Center, Nagoya
NOT_YET_RECRUITING
UKM Specialist Children's Hospital, Kuala Lumpur
RECRUITING
University Malaya Medical Centre, Kuala Lumpur
NOT_YET_RECRUITING
Sarawak General Hospital, Kuching
NOT_YET_RECRUITING
Shifa International Hospital, Islamabad
NOT_YET_RECRUITING
Aga Khan University Hospital, Karachi
RECRUITING
King Abdullah Specialist Children's Hospital, Riyadh
RECRUITING
KK Women's and Children's Hospital, Singapore
RECRUITING
Vietnam National Children's Hospital, Hanoi
NOT_YET_RECRUITING
City Children's Hospital, Ho Chi Minh City
RECRUITING
Alberta Children's Hospital, Calgary
TERMINATED
BC Children's Hospital, Vancouver
RECRUITING
IWK Health Centre, Halifax
RECRUITING
McMaster Children's Hospital, Hamilton
RECRUITING
London Health Sciences Centre, London
RECRUITING
Children's Hospital of Eastern Ontario, Ottawa
RECRUITING
Centre hospitalier universitaire Sainte-Justine, Montreal
TERMINATED
Montreal Children's Hospital, Montreal
RECRUITING
Centre hospitalier de l'Université Laval, Québec
TERMINATED
Royal University Hospital, Saskatoon
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Canadian Critical Care Trials Group
OTHER
Children's Hospital of Eastern Ontario
OTHER
Jerry Zimmerman
OTHER