Aggressive Antipyretics for Fever Reduction in CNS Malaria

PHASE2CompletedINTERVENTIONAL
Enrollment

256

Participants

Timeline

Start Date

January 7, 2019

Primary Completion Date

December 2, 2022

Study Completion Date

December 2, 2022

Conditions
MalariaSeizuresComaParasitemiaHyperpyrexiaFever
Interventions
DRUG

Acetaminophen

"30 mg/kg load then 15mg/kg Q6 hours for the Aggressive Antipyretic Arm~Acetaminophen is also given to children in the placebo arm when they have a fever over 38.5 degrees Celsius during scheduled clinical assessments"

DRUG

Ibuprofen

10 mg/kg Q6 hours for the Aggressive Antipyretic Arm

DRUG

placebo for acetaminophen

"placebo for acetaminophen for children in the Usual Care arm~For children in the Aggressive Antipyretic Arm, when they have a temperature over 38.5 degrees Celsius they are treated with a placebo"

DRUG

placebo for ibuprofen

placebo for ibuprofen

Trial Locations (3)

Unknown

Pediatric Research Ward at Queen Elizabeth Central Hospital, Blantyre

Chipata Central Hospital, Chipata

University Teaching Hospital's Lusaka Childrens Hospital, Lusaka

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

University of Rochester

OTHER

NCT03399318 - Aggressive Antipyretics for Fever Reduction in CNS Malaria | Biotech Hunter | Biotech Hunter