256
Participants
Start Date
January 7, 2019
Primary Completion Date
December 2, 2022
Study Completion Date
December 2, 2022
Acetaminophen
"30 mg/kg load then 15mg/kg Q6 hours for the Aggressive Antipyretic Arm~Acetaminophen is also given to children in the placebo arm when they have a fever over 38.5 degrees Celsius during scheduled clinical assessments"
Ibuprofen
10 mg/kg Q6 hours for the Aggressive Antipyretic Arm
placebo for acetaminophen
"placebo for acetaminophen for children in the Usual Care arm~For children in the Aggressive Antipyretic Arm, when they have a temperature over 38.5 degrees Celsius they are treated with a placebo"
placebo for ibuprofen
placebo for ibuprofen
Pediatric Research Ward at Queen Elizabeth Central Hospital, Blantyre
Chipata Central Hospital, Chipata
University Teaching Hospital's Lusaka Childrens Hospital, Lusaka
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
University of Rochester
OTHER