768
Participants
Start Date
May 7, 2018
Primary Completion Date
October 11, 2019
Study Completion Date
March 15, 2020
Standard strategy
"RRT is initiated within 12 hours after documentation of serum urea concentration \>40 mmol/l and/or an oliguria/anuria for more than 72 hours. The timing of its initiation will be recorded and RRT will continue until criteria for cessation are observed. This arm corresponds to the delayed strategy in the published AKIKI trial (NEJM 2016),"
Delayed strategy
"RRT will be initiated only if one or more of above-mentioned potentially severe situations occur (identical to those used during the observational study) or if serum urea concentration reaches 50 mmol/L (this level being chosen in order to avoid extreme elevations of serum urea levels as mentioned above). The physician in charge will be allowed to try a medical treatment. Patients will not receive RRT whatever the duration of anuria/oliguria if any above-mentioned indication for RRT is not present. When required, RRT will be performed with the same modalities and stopped according to the same criteria as in the no further delayed RRT strategy, with special care to avoid dialysis disequilibrium syndrome (see below).~The decision to initiate RRT in the delayed strategy arm of the trial will have to be approved by the attending physician(s) involved in patient's care in order to make sure that it corresponds to her/his usual practice."
Chu Hegp - Aphp, Paris
CHU Pitiè Salpêtrière - Pneumologie et réanimation médicale - APHP, Paris
CHD Vendée, La Roche-sur-Yon
CHU Louis Mourier - APHP, Colombes
CH Alès, Alès
CHU Amiens, Amiens
CH Avignon, Avignon
Groupe Hospitalier Carnelle-Portes de l'Oise Site Beaumont / Oise, Beaumont-sur-Oise
Hopital Nord Franche Comté - Belfort, Belfort
CH Béthune Beuvry - Germont et Gauthier, Béthune
CHU Avicenne - APHP, Bobigny
CHU Ambroise Paré - APHP, Boulogne-Billancourt
CH Bourg en Bresse / Fleyriat, Bourg-en-Bresse
Gabriel Montpied - CHU Clermont Ferrand, Clermont-Ferrand
CH Sud Francilien, Corbeil-Essonnes
CHU Henri Mondor - APHP, Créteil
CH Dieppe, Dieppe
Hôpital François Mitterand - CHU Dijon, Dijon
CH Le Mans, Le Mans
CH Dr Schaffner - Lens, Lens
Hôpital Roger Salengro / CHRU Lille, Lille
Centre Hospitalier Bretagne sud - Lorient, Lorient
GH Edouard Herriot - Lyon, Lyon
Hôpital Nord - Anesthésie Réa - APHM, Marseille
Hôpital Nord - DRIS - APHM, Marseille
La Timone - APHM, Marseille
Hopital de Mercy, CHR Metz-Thionville, Metz
Hôpital Lapeyronie - CHU Montpellier, Montpellier
Hôpital St Eloi - CHU Montpellier, Montpellier
Hotel Dieu - Anesthésie Réanimation - CHU Nantes, Nantes
Hotel Dieu - Réanimation MIR - CHU Nantes, Nantes
Hôpital Nord Laennec - CHU Nantes, Nantes
CHU Nimes - Caremeau, Nîmes
CHU Pitié-Salpêtrière - Réanimation médicale - APHP, Paris
CHU Lyon Sud, Pierre-Bénite
CHU Poitiers, Poitiers
CH René DUBOS, Pontoise
CHU Charles Nicolle, Rouen
CHU Saint Etienne, Saint-Etienne
CH André Mignot, Versailles
CHU pointe à Pitre / Abymes, Pointe-à-Pitre
Assistance Publique - Hôpitaux de Paris
OTHER