1,054
Participants
Start Date
December 18, 2017
Primary Completion Date
October 3, 2022
Study Completion Date
June 30, 2027
Talazoparib with enzalutamide
Talazoparib 0.5 mg/day plus enzalutamide 160mg/day
Placebo with enzalutamide
Placebo plus enzalutamide 160 mg/day
Auckland City Hospital, Auckland
Semmelweis Egyetem Urologiai Klinika, Budapest
Országos Onkológiai Intézet, Budapest
Uzsoki Utcai Korhaz, Budapest
Uzsoki Utcai Kórház, Budapest
Clinique Saint-Pierre Ottignies, Ottignies
Akershus University Hospital, Lorenskog
Sykehusapoteket Ostfold, Kalnes, Grålum
Ostfold County Hospital, Kalnes, Grålum
St. Vincent's Hospital Sydney, Darlinghurst
Chris O'Brien Lifehouse, Camperdown
Wits Clinical Research, Parktown
The Medical Oncology Centre of Rosebank, Johannesburg
Port Macquarie Base Hospital, Port Macquarie
AZ Klina, Brasschaat
Peter MacCallum Cancer Centre, Melbourne
Peter MacCallum Cancer Centre, North Melbourne
Tauranga Urology Research Limited, Tauranga
Waikato Hospital, Hamilton
ICON Cancer Centre Chermside, Chermside
Debreceni Egyetem Klinikai Kozpont, Debrecen
Icon Cancer Centre Wesley, Auchenflower
River City Pharmacy, Auchenflower
ICON Cancer Centre South Brisbane, South Brisbane
Integrated Clinical Oncology Network Pty Ltd (ICON), South Brisbane
Princess Alexandra Hospital, Brisbane
ICON Cancer Centre Southport, Southport
CHU UCL Namur site Godinne, Yvoir
Cancercare Langenhoven Drive Oncology Centre, Port Elizabeth
Outeniqua Cancercare Oncology Unit, George
St. Olavs Hospital, Trondheim University Hospital, Trondheim
Cape Town Oncology Trials, Kraaifontein
Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intezet, Pécs
Cancercare Rondebosch Oncology, Cape Town
Canterbury District Health Board, Christchurch
AZ Groeninge, Kortrijk
A.Z. Sint-Lucas, Ghent
UZ Gent, Ghent
AOU San Luigi Gonzaga, Orbassano
Clinical Trial Pharmacy, National Cancer Center, Goyang-si
National Cancer Center, Goyang-si
Montefiore Medical Center - Montefiore Medical Park, The Bronx
Premier Medical Group of the Hudson Valley PC, Poughkeepsie
Associated Medical Professionals of New York, PLLC, Syracuse
UPMC Hillman Cancer Center - Upper St. Clair, Bethel Park
UPMC Hillman Cancer Center - Monroeville, Monroeville
UPMC Hillman Cancer Center, Pittsburgh
UPMC Hillman Cancer Center - Passavant (HOA), Pittsburgh
UPMC Hillman Cancer Center - Passavant (OHA), Pittsburgh
UPMC Hillman Cancer Center - Washington, Washington
UPMC Hillman Cancer Center - Uniontown, Uniontown
UPMC Hillman Cancer Center - Arnold Palmer - Mt View, Greensburg
Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela
UPMC Hillman Cancer Center - Northwest, Seneca
UPMC Hillman Cancer Center - Altoona, Altoona
Karolinska Universitetssjukhuset, Solna
Keystone Urology Specialists, Lancaster
Universitaetsklinikum Hamburg-Eppendorf, Hamburg
Turku University Hospital, Turku
Inova Schar Cancer Institute Infusion Pharmacy, Fairfax
Inova Schar Cancer Institute, Fairfax
ASST di Cremona, Cremona
Hospital Universitario La Princesa, Madrid
Hospital General Universitario Gregorio Maranon, Madrid
MD Anderson Cancer Center, Madrid
Hospital Universitario 12 De Octubre, Madrid
Carolina Urologic Research Center, Myrtle Beach
Hospital Universitario Virgen de la Arrixaca, El Palmar
Piedmont Cancer Institute, Fayetteville
Piedmont Cancer Institute, Newnan
Southeastern Regional Medical Center, Newnan
Piedmont Cancer Institute, Atlanta
Florida Cancer Specialists, Daytona Beach
Florida Cancer Specialists, The Villages
Florida Cancer Specialists, Gainesville
Florida Cancer Specialists, Altamonte Springs
Florida Cancer Specialists, Orange City
Florida Cancer Specialists, Tavares
Florida Cancer Specialists, Winter Park
AdventHealth Medical Group Hermatology and Oncology, Orlando
Investigational Drug Services, Advent Health Orlando, Orlando
Florida Cancer Specialists, Orlando
Florida Cancer Specialists, Vero Beach
Hopital Saint Andre - CHU de Bordeaux, Bordeaux
Florida Cancer Specialists, West Palm Beach
Florida Cancer Specialists, Wellington
Florida Cancer Specialists, Brandon
Tampere University Hospital, Tampere
Florida Cancer Specialists, Tampa
Florida Cancer Specialists, St. Petersburg
Florida Cancer Specialists, Clearwater
Florida Cancer Specialists, Largo
Lakeland Regional Health Hollis Cancer Center, Lakeland
Florida Cancer Specialists, Fort Myers
CHU Montpellier-Hopital Saint Eloi, Montpellier
Florida Cancer Specialists, Lecanto
Florida Cancer Specialists, Ocala
Florida Cancer Specialists, Spring Hill
Florida Cancer Specialists, New Port Richey
Florida Cancer Specialists, Stuart
Urology Associates P.C., Nashville
The Vanderbilt Clinic, Nashville
Vanderbuilt University Medical Center, Department of Urology, Nashville
Tennesse Oncology, PLLC, Cleveland
Greco-Hainesworth Tennessee Oncology Centers for Research, Chattanooga
Tennessee oncology, PLLC, Chattanooga
Ospedale Santa Chiara, Trento
Azienda Ospedaliero-Universitaria Policlinico Sant' Orsola Malpighi, Bologna
Universitaetsklinikum Duesseldorf, Düsseldorf
Kyungpook National University Chilgok Hospital, Daegu
Clinical Research Solutions, Middleburg Heights
TriState urologic Services PSC Inc., dba The Urology Group, Cincinnati
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola
Clark Memorial Hospital Radiology, Jeffersonville
First Urology, PSC, Jeffersonville
Universitaetsklinikum Muenster, Münster
Pusan National University Hospital, Busan
University of Iowa Hospital and Clinics, Iowa City
University of Wisconsin Clinical Science Center, Madison
University of Wisconsin Hospital & Clinics, Madison
Midwestern Regional Medical Center, Zion
AMITA Health Adventist Medical Center Hinsdale, Hinsdale
AMITA Health Cancer Institute, Hinsdale
Cook County Health (CCH), Chicago
John H. Stroger, Jr. Hospital of Cook County/IND Pharmacy, Chicago
VA Saint Louis Healthcare System, St Louis
Centre d'Oncologie du Pays-Basque, Bayonne
Clinique Ramsay Belharra, Bayonne
The University of Kansas Clinical Research Center, Fairway
The University of Kansas Cancer Center, Westwood
Clinique Sainte Anne, Strasbourg
Hopitaux Universitaires de Strasbourg - ICANS, Strasbourg
XCancer Omaha / Urology Cancer Center, PC d/b/a XCancer, Omaha
Universitaetsklinik Heidelberg, Heidelberg
Centre Léon Bérard, Lyon
Ochsner Clinic Foundation, New Orleans
Kuopio University Hospital, Kuopio
Clinique Victor Hugo Le Mans, Le Mans
Studienpraxis Urologie, Nürtingen
OU Health Stephenson Cancer Center, Oklahoma City
Diagnostikzentrum, Kirchheim
Hopital Saint-Louis, Paris
Hopital Europeen Georges Pompidou, Paris
Baylor Scott & White Medical Center - Temple, Temple
Houston Metro Urology, Houston
Urology Austin, PLLC, Round Rock
Urology Austin PLLC, Austin
Rio Grande Urology, P.A., El Paso
University of Colorado Denver CTO/CTRC, Aurora
University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora
University of Colorado Hospital- Anschutz Inpatient Pavilion, Aurora
University of Colorado Hospital- Anschutz Outpatient Pavilion, Aurora
University of Colorado Hospital, Aurora
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale - Napoli, Napoli
The Urology Center of Colorado, Denver
Farmington Health Center -University of Utah, Farmington
South Jordan Health Center -University of Utah, South Jordan
Huntsman Cancer Hospital, Salt Lake City
University of Utah, Huntsman Cancer Institute, Salt Lake City
Redwood Health Center-University of Utah, Salt Lake City
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Mesa
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Mesa
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Chandler
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Scottsdale
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Gilbert
Arizona Urology Specialists, Tucson
Arizona Urology Specialists, Tucson
CHD Vendée, La Roche-sur-Yon
Urology Group of New Mexico, Albuquerque
San Juan Oncology Associates, Farmington
UCLA Clark Urology Center, Los Angeles
Beverly Hills Cancer Center, Beverly Hills
Oulun yliopistollinen sairaala, Oulu
VA Long Beach Healthcare System, Long Beach
Glendale Adventist Medical Center, Glendale
South County Hematology/Oncology, Chula Vista
Sharp Rees-Stealy, Chula Vista
Cancer Center Oncology Medical Group, La Mesa
Medical Oncology Associates-SD, San Diego
Sharp Memorial Hospital Investigational Pharmacy, San Diego
Sharp Rees-Stealy, San Diego
Hopital Foch, Suresnes
Hopital Foch, Suresnes
Desert Hematology Oncology Medical Group, Incorporation, Rancho Mirage
Eisenhower Medical Center, Rancho Mirage
Loma Linda University Cancer Center - Records Management Only, Loma Linda
Loma Linda University Cancer Center - Hematology/Oncology Clinic, Loma Linda
Loma Linda University Medical Center, Loma Linda
University of California, Irvine Medical Center, Orange
Stanford Cancer Institute, Palo Alto
Stanford Health Care, Stanford
Institut Gustave Roussy, Villejuif
Marin Cancer Care, Inc., Greenbrae
Kaiser Sunnyside Medical Center, Clackamas
Providence Cancer Institute Willamette Falls, Oregon City
Kaiser Westside Medical Center, Hillsboro
Providence Cancer Institute Newberg Clinic, Newberg
Providence Newberg Medical Center, Newberg
Providence Cancer Institute Franz Clinic, Portland
Providence Portland Medical Center, Portland
Providence Oncology and Hematology Care Clinic - Westside, Portland
Providence St Vincent Medical Center, Portland
Kaiser Permanente Northwest, Portland
Swedish Cancer Institute, Seattle
Swedish Medical Center, Seattle
Alaska Urological Institute dba Alaska Clinical Research Center, Anchorage
Beijing Hospital, Beijing
Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing
Peking University First Hospital / Urology Department, Beijing
Beijing Cancer Hospital, Beijing
Peking University Third Hospital, Beijing
Jilin Cancer Hospital, Changchun
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai
Zhongshan Hospital Fudan University, Shanghai
Fudan University Cancer Hospital, Deptartment of Urology, Shanghai
Shanghai Tenth People's Hospital, Shanghai
Shanghai General Hospital, Shanghai
The Fifth People's Hospital of Shanghai, Fudan University, Shanghai
Nanjing First Hospital, Nanjing
Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School, Nanjing
Nanjing First Hospital, Nanjing
Wuxi People's Hospital, Wuxi
The First People's Hospital of Lianyungang, Lianyungang
Nantong Tumor Hospital, Nantong
The First affiliated Hospital of Anhui Medical University, Hefei
The Second Hospital of Tianjin Medical University, Tianjin
Zhejiang Provincial People's Hospital, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
The first affiliated hospital of Ningbo university, Ningbo
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
The First Affiliated Hospital of Nanchang University, Nanchang
The First Affiliated Hospital Of Fujian Medical University, Fuzhou
First Affiliated Hospital of Xiamen University, Xiamen
Chongqing University Cancer Hospital, Chongqing
Union Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
West China Hospital of Sichuan University, Chengdu
Yunnan Cancer Hospital, Kunming
The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an
Centro de Investigaciones Clinicas Vina del Mar, Viña del Mar
Centro de Investigaciones Clinicas Vina del Mar, Viña del Mar
Rambam Health Care Campus, Haifa
Centro de Investigacion Clinica del Sur, Temuco
James Lind Centro de Investigación del Cáncer, Araucania
Osaka International Cancer Institute, Osaka
Tel Aviv Sourasky Medical Center, Tel Aviv
Sociedad Prosalud Montes y Orlandi Ltda. Fantasy name (Orlandi Oncologia), Santiago
Shaare Zedek Medical Center, Jerusalem
Clara Maass Medical Center, Belleville
New Jersey Cancer Care and Blood Disorders, Belleville
University Radiology, Nutley
New Jersey Urology, LLC, Voorhees Township
Centro de Investigacion Pergamino SA - Clinica Pergamino SA, Pergamino
Instituto de Oncologia de Rosario, Rosario
Hospital Británico de Buenos Aires, Caba
"Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno Cemic", Caba
Clinica Universitaria Reina Fabiola, Córdoba
Hospital Privado Centro Medico de Cordoba, Córdoba
Instituto Nacional de Câncer José de Alencar Gomes da Silva - INCA, Rio de Janeiro
Instituto Nacional de Câncer José de Alencar Gomes da Silva - INCA, Rio de Janeiro
Hospital Universitario Pedro Ernesto-Centro de Pesquisas (CEPUSA), Rio de Janeiro
Hospital CopaDor, Rio de Janeiro
Hospital Gloria D'Or, Rio de Janeiro
Oncologia D'Or, Rio de Janeiro
Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro
Oncologia D'Or, Rio de Janeiro
Associacao Hospital de Caridade de Ijui, Ijuí
Sociedade Beneficencia e Caridade de Lajeado - Hospital Bruno Born, Lajeado
Centro de Pesquisa Clinica em Oncologia - Hospital Sao Lucas da Pontificia Universidade Catolica, Porto Alegre
Centro Gaucho Integrado - Hospital Mae de Deus, Porto Alegre
MedPlex Eixo Norte, Porto Alegre
Hospital Nossa Senhora da Conceicao - Grupo Hospitalar Conceicao, Porto Alegre
Fundacao Pio XII - Hospital de Cancer de Barretos, Barretos
Faculdade de Medicina do ABC - Centro de Estudos e Pesquisa de Hematologia e Oncologia (CEPHO), Santo André
Faculdade de Medicina do ABC - Centro de Estudos e Pesquisas de Hematologia e Oncologia (CEPHO), Santo André
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Instituto do Cancer do Estado de Sao Paulo-ICESP-Nucleo de Pesquisa, São Paulo
Hospital Alemão Oswaldo Cruz, São Paulo
Arthur J.E Child Comprehensive Cancer Centre, Calgary
The Ottawa Hospital Cancer Center, Ottawa
Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean, Chicoutimi
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal
Jewish General Hospital, Montreal
Centre integre universitaire de sante et de services sociaux de l'Estrie, Sherbrooke
Second Affiliated Hospital of Suzhou University, Suzhou
Clinica Monte Carmelo S.C.R.LTDA., Arequipa
Fakultní nemocnice Hradec Králové, Hradec Králové
Fakultni nemocnice Ostrava, Ostrava-Poruba
Multiscan s.r.o., Pardubice
Fakultní nemocnice Královské Vinohrady, Prague
HUS Helsinki University Hospital, Helsinki
Docrates Cancer Center, Helsinki
Azienda Ospedaliera S. Maria, Terni
Nagoya University Hospital, Nagoya
Hirosaki University School of Medicine & Hospital, Hirosaki
National Cancer Center Hospital East, Kashiwa
National Hospital Organization Shikoku Cancer Center, Matsuyama
National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure
National Hospital Organization Hokkaido Cancer Center, Sapporo
Hokkaido University Hospital, Sapporo
Kanazawa University Hospital, Kanazawa
Yokohama City University Medical Center, Yokohama
Yokosuka Kyosai Hospital, Yokosuka
Kindai University Hospital, Sayama
Osaka University Hospital, Suita
Hamamatsu University School of Medicine, University Hospital, Hamamatsu
National Hospital Organization Tokyo Medical Center, Meguro-ku
Keio University Hospital, Shinjuku-ku
Chiba Cancer Center, Chiba
National Hospital Organization Kyushu Cancer Center, Fukuoka
Kagoshima University Hospital, Kagoshima
National Hospital Organization Kumamoto Medical Center, Kumamoto
Tokushima University Hospital, Tokushima
Yamagata Prefectural Central Hospital, Yamagata
Yamagata University Hospital, Yamagata
Oslo University Hospital -Ullevål & Radiumhospitalet, Oslo
"Hospital Militar Central Coronel Luis Arias Schreiber", Lima
Clinica Internacional Sede San Borja, Lima
Clinica Oncosalud, Lima
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. ks. B. Markiewicza, Brzozów
Szpitale Pomorskie Sp. z o.o. Oddzial Onkologii i Radioterapii, Gdynia
"Przychodnia Lekarska Komed Roman Karaszewski", Konin
Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Otwock
City Clinic Sp. z o.o., Warsaw
NZOZ Szpital Mazovia; Oddzial urologiczny, Warsaw
Centro Clínico Académico - Braga, Associação (2CABraga), Braga
Instituto Português Oncologia de Coimbra Francisco Gentil - E.P.E, Coimbra
Fundação Champalimaud, Lisbon
Hospital da Luz Lisboa, Lisbon
Centro Hospitalar do Porto - Hospital de Santo Antonio, Porto
Instituto Português de Oncologia do Porto Francisco Gentil, Porto
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Cancer Center Clinical Trial, Asan Medical Center, Seoul
Clinical Trials Center Pharmacy, Seoul
Samsung Medical Center, Seoul
Clinical Trial Pharmacy, The Catholic University of Korea, Seoul
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
Hospital General Universitario de Elche, Elche
Institut Catala d'Oncologia - ICO L'Hospitalet, L'Hospitalet de Llobregat
Corporacio Sanitaria i Universitaria Parc Tauli, Sabadell
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
Sahlgrenska Universitetssjukhuset, Gothenburg
Cancercentrum, Umeå
University Hospitals Plymouth NHS Trust, Plymouth
Oxford University Hospitals NHS Foundation Trust, Oxford
Greater Glasgow Health Board J B Russell House, Gartnavel Royal Hospital, Glasgow
The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington
Royal Cornwall Hospitals NHS Trust, Cornwall
The Clatterbridge Cancer Centre - Liverpool, Liverpool
Imperial College Healthcare NHS Trust, London
Imperial College Healthcare NHS Trust, London
Imperial College Healthcare NHS Trust, Charing Cross Hospital, London
Lead Sponsor
Collaborators (1)
Astellas Pharma Inc
INDUSTRY
Pfizer
INDUSTRY