Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD

CompletedOBSERVATIONAL
Enrollment

27

Participants

Timeline

Start Date

December 18, 2018

Primary Completion Date

January 28, 2022

Study Completion Date

July 11, 2023

Conditions
Alzheimer Disease
Interventions
DEVICE

GRASP Dynamic Contrast-Enhanced (DCE) MRI

Golden-angle Radial Sparse Parallel (GRASP) DCE MRI is an MRI sequence designed to improve spatial and temporal resolution while enabling retrospective reconstruction with flexible temporal resolution.

DEVICE

3T Brain Scan

Up to 60 minutes, a portion of which uses the GRASP DCE-MRI sequence.

DRUG

Gadolinium-based Contrast Agent (GBCA) for MRI

Gadavist/Gadobutrol is a gadolinium-based contrast agent indicated for intravenous use in diagnostic magnetic resonance imaging (MRI) in adults and children (2 years of age and older) to detect and visualize areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system.

Trial Locations (1)

10016

New York University School of Medicine, New York

All Listed Sponsors
lead

NYU Langone Health

OTHER

NCT03389698 - Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD | Biotech Hunter | Biotech Hunter