Multiple Sclerosis-Simvastatin Trial 2

PHASE3CompletedINTERVENTIONAL
Enrollment

964

Participants

Timeline

Start Date

March 28, 2018

Primary Completion Date

July 26, 2024

Study Completion Date

August 25, 2024

Conditions
Secondary Progressive Multiple Sclerosis (SPMS)
Interventions
DRUG

Simvastatin

"* One (1 = 40mg) simvastatin tablet once daily at night for 1 month~* Two (2 = 80mg) simvastatin tablets once daily at night, for the next 35 to 53 months"

DRUG

Placebo

"* One (1) placebo tablet once daily at night for 1 month~* Two (2) placebo tablets once daily at night, for the next 35 to 53 months"

Trial Locations (31)

BT9 7AB

Belfast City Hospital, Belfast

BD5 ONA

St Luke s Hospital, Bradford

BN2 5BE

Royal Sussex County Hospital, Brighton

BS10 5NB

Southmead Hospital, Bristol

CB2 0QQ

Addenbrooke's Hospital, Cambridge

CT1 3NG

Kent and Canterbury Hospital, Canterbury

CF14 4XW

University Hospital of Wales, Cardiff

CV2 2DX

University Hospital Coventry and Warwickshire, Coventry

EH16 4SB

The Anne Rowling Regenerative Neurology Clinic, Edinburgh

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

G51 4TF

The Queen Elizabeth University Hospital, Glasgow

HU3 2JZ

Hull Royal Infirmary, Hull

LS1 3EX

Leeds General Infirmary, Leeds

L9 7LJ

The Walton Centre NHS Foundation Trust, Liverpool

RM7 0AG

Queen's Hospital, Barking, Havering and Redbridge University Hospitals, London

SE18 4QH

Queen Elizabeth Hospital, London

W6 8RF

Charing Cross Hospital, London

WC1N 3BG

University College London Hospital, London

M6 8HD

Salford Royal Hospital, Manchester

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

NR4 7UY

Norfolk and Norwich University Hospital, Norwich

NG7 2UH

Queen's Medical Centre, Nottingham

OX3 9DU

John Radcliffe Hospital, Oxford

PL6 8BH

Derriford Hospital, Plymouth

BH15 2JB

Poole Hospital, Poole

PR2 9HT

Royal Preston Hospital, Preston

S10 2JF

Royal Hallamshire Hospital, Sheffield

SO16 6YD

Southampton General Hospital, Southampton

ST4 6QG

University Hospital of North Staffordshire, Stoke-on-Trent

Unknown

Morriston & Neath Port Talbot Hospitals (Abertawe Bro Morgannwg University Local Health Board), Swansea

TQ2 7AA

Torbay Hospital, Torquay

All Listed Sponsors
collaborator

University of Edinburgh

OTHER

collaborator

Queen Mary University of London

OTHER

collaborator

London School of Hygiene and Tropical Medicine

OTHER

collaborator

University of Leeds

OTHER

collaborator

The Leeds Teaching Hospitals NHS Trust

OTHER

collaborator

Imperial College Healthcare NHS Trust

OTHER

lead

University College, London

OTHER

NCT03387670 - Multiple Sclerosis-Simvastatin Trial 2 | Biotech Hunter | Biotech Hunter