1,638
Participants
Start Date
April 8, 2018
Primary Completion Date
October 19, 2021
Study Completion Date
June 27, 2022
10% povidone-iodine (1% free iodine) in purified water
Participant recruitment will begin with the clinical sites using their assigned pre-operative antiseptic skin solution for all open fracture surgeries for a two-month period.
4% chlorhexidine gluconate (CHG) in purified water
Once the first intervention phase is completed, each site will crossover to the opposite study solution. Each site will need to develop local procedures to ensure a successful crossover. They will use the second solution for all open fracture surgeries for a two-month period, and will then crossover back to the solution in the first intervention phase.
University of Maryland, R Adams Cowley Shock Trauma Center, Baltimore
Greenville Health System, Greenville
University of Florida, Gainesville
Vanderbilt University, Nashville
Wright State University / Miami Valley Hospital, Dayton
Indiana University Health Methodist Hospital, Indianapolis
McGovern Medical School at University of Texas Health Science Center Houston, Houston
San Antonio Military Medical Center, Fort Sam Houston
The CORE Institute / Banner University Medical Center, Phoenix
Banner - University Medical Center Tucson, Tucson
University of California San Francisco, San Francisco
Hamilton Health Sciences, Hamilton
McMaster University, Center for Evidence-Based Orthopaedics, Hamilton
Hospital Parc Tauli de Sabadell, Barcelona
Vall d'Hebron University Hospital, Barcelona
McMaster University
OTHER
United States Department of Defense
FED
University of Maryland, Baltimore
OTHER