A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

545

Participants

Timeline

Start Date

April 18, 2018

Primary Completion Date

April 28, 2025

Study Completion Date

December 16, 2025

Conditions
Hepatocellular CarcinomaLiver Cancer
Interventions
BIOLOGICAL

Nivolumab

Specified dose on specified days

OTHER

Placebo

specified dose on specified days

Trial Locations (184)

0

Local Institution - 0248, Santiago

Local Institution - 0256, Bogotá

100

Local Institution - 0207, Taipei

105

Local Institution - 0173, Taipei

333

Local Institution - 0175, Taoyuan District

632

Local Institution - 0176, Yunlin

704

Local Institution - 0131, Tainan City

736

Local Institution - 0174, Tainan City

883

Local Institution - 0204, Kaohsiung City

1023

Local Institution - 0240, Auckland

1070

Local Institution - 0033, Brussels

1090

Local Institution - 0003, Vienna

1100

Local Institution - 0001, Vienna

1200

Local Institution - 0064, Brussels

1629

Local Institution - 0254, Pilar

2000

Local Institution - 0244, Rosario

2050

Local Institution - 0166, Camperdown

2139

Local Institution - 0141, Concord

2148

Local Institution - 0239, Blacktown

2650

Local Institution - 0068, Edegem

3000

Local Institution - 0108, Leuven

3084

Local Institution - 0224, Heidelberg

4029

Local Institution - 0220, Herston

5000

Local Institution - 0164, Adelaide

5737

Local Institution - 0243, Gorriti

6009

Local Institution - 0124, Nedlands

8036

Local Institution - 0012, Graz

9000

Local Institution - 0071, Ghent

10016

Local Institution - 0075, New York

10029

Local Institution - 0208, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10408

Local Institution - 0190, Goyang-si

10601

Local Institution - 0219, White Plains

11217

Local Institution - 0129, Taipei

13353

Local Institution - 0258, Berlin

13620

Local Institution - 0169, Seongnam-si

14004

Local Institution - 0016, Córdoba

16499

Local Institution - 0191, Suwon

20014

Local Institution - 0072, Donostia / San Sebastian

20133

Local Institution - 0091, Milan

23249

McGuire VA Medical Center, Richmond

28007

Local Institution - 0199, Madrid

28046

Local Institution - 0109, Madrid

29200

Local Institution - 0052, Brest

30322

Local Institution - 0009, Atlanta

30625

Local Institution - 0040, Hanover

31008

Local Institution - 0100, Pamplona

33125

Miami VA Healthcare System, Miami

33136

Sylvester Comprehensive Cancer Center/ UMHC, Miami

33612

Local Institution - 0163, Tampa

34295

Local Institution - 0043, Montpellier

35033

Local Institution - 0212, Rennes

35128

Local Institution - 0103, Padua

36207

Local Institution - 0081, Anniston

38043

Local Institution - 0013, Grenoble

40138

Local Institution - 0102, Bologna

40447

Local Institution - 0130, Taichung

40705

Local Institution - 0140, Taichung

41013

Local Institution - 0028, Seville

41124

Local Institution, Modena

41944

Local Institution - 0177, Daegu

42270

Local Institution - 0044, Saint-Priest-en-Jarez

44109

MetroHealth Medical Center, Cleveland

45147

Local Institution - 0026, Essen

46026

Local Institution - 0082, Valencia

47014

Local Institution - 0104, Meldola

48109

University of Michigan, Ann Arbor

50009

Local Institution - 0097, Zaragoza

50134

Local Institution - 0077, Florence

50612

Local Institution - 0188, Gyeongsangnam-do

50937

Local Institution - 0050, Cologne

51100

Local Institution - 0098, Reims

52057

Local Institution - 0024, Aachen

53127

Local Institution - 0020, Bonn

54511

Local Institution - 0011, Vandœuvre-lès-Nancy

55131

Local Institution - 0048, Mainz

55404

Minnesota Oncology Hematology, P.A., Minneapolis

58128

Local Institution - 0178, Jeollanam-do

59037

Local Institution - 0222, Lille

60590

Local Institution - 0093, Frankfurt am Main

63003

CHU Estaing, Clermont-Ferrand

63110

Local Institution - 0209, St Louis

64000

Local Institution - 0121, Monterrey

64460

Local Institution - 0264, Monterrey

66205

Local Institution - 0025, Westwood

66421

Local Institution - 0019, Homburg

68167

Universitatsmedizin Mannheim, Mannheim

69317

Local Institution - 0051, Lyon

70112

Local Institution - 0086, New Orleans

72076

Local Institution - 0008, Tübingen

75246

Texas Oncology Sammons Cancer Center, Dallas

75390

Local Institution - 0156, Dallas

75702

Local Institution - 0273, Tyler

78250

Local Institution - 0226, San Luis Potosí City

78705

Local Institution - 0272, Austin

80045

Local Institution - 0235, Aurora

80131

Azienda Ospedaliera Specialistica dei Colli Monaldi-Cotugno-CTO, Napoli

Local Institution - 0119, Napoli

81377

Local Institution - 0096, München

85054

Mayo Clinic in Arizona - Phoenix, Phoenix

85711

Arizona Oncology Associates, PC - HOPE, Tucson

86021

Local Institution, Poitiers

90095

Local Institution - 0135, Los Angeles

92110

Local Institution - 0046, Clichy

93000

Local Institution - 0057, Bobigny

94010

Local Institution - 0061, Créteil

94115

Local Institution - 0085, San Francisco

94304

Local Institution - 0088, Palo Alto

94800

Local Institution - 0054, Villejuif

97078

Local Institution, Würzburg

97225

Local Institution - 0206, Portland

98109

Local Institution - 0154, Seattle

98125

Local Institution - 0136, Messina

115478

Local Institution - 0230, Moscow

119228

Local Institution - 0042, Singapore

163045

Arkhangelsk Clinical Oncological Dispensary, Arkhangelsk

169610

Local Institution - 0067, Singapore

188663

Local Institution, Leningrad Region

198255

Local Institution - 0032, Saint Petersburg

200542

Local Institution - 0074, Craiova

300166

Local Institution - 0070, Timișoara

308433

Local Institution - 0039, Singapore

400015

Local Institution - 0232, Cluj-Napoca

500091

Local Institution, Brasov

900591

Local Institution - 0242, Constanța

999077

Local Institution - 0120, Hong Kong

1040045

Local Institution - 0196, Chuo-ku

1138655

Local Institution - 0215, Bunkyo-ku

1808610

Local Institution - 0210, Musashino-shi

2520598

Local Institution - 0247, Viña del Mar

2608677

Local Institution - 0187, Chiba

2778577

Local Institution - 0183, Kashiwa-shi

5438555

Local Institution - 0203, Osaka

5458586

Local Institution - 0198, Osaka

5898511

Local Institution, Ōsaka-sayama

6638501

Local Institution - 0216, Nishinomiya-shi

7710007

Local Institution - 0246, Santiago

8300011

Local Institution - 0201, Kurume-shi

8380420

Local Institution - 0245, Santiago

8608556

Local Institution - 0202, Kumamoto

9208641

Local Institution - 0180, Kanazawa

30130-090

Local Institution - 0090, Belo Horizonte

14780-070

Local Institution - 0275, Barretos

01246-000

Local Institution - 0237, Cerqueira César

15090-000

Local Institution, São José do Rio Preto

08270-120

Local Institution, São Paulo

01308-050

Local Institution - 0023, São Paulo

01509-010

Local Institution - 0236, São Paulo

T2N 4Z6

Local Institution, Calgary

T6G 1Z2

Local Institution - 0116, Edmonton

06202

Local Institution - 0037, Nice

04103

Local Institution, Leipzig

39104 Magdeburg

Local Institution - 0036, Magdeburg

Unknown

Local Institution - 0076, Hong Kong

09042

Local Institution - 0134, Monserrato

00168

Fondazione Policlinico Gemelli - Universita Cattolica del Sacro Cuore, Rome

0600033

Local Institution - 0184, Sapporo

0608648

Local Institution - 0200, Sapporo

0208505

Local Institution - 0257, Morioka

565-0871

Local Institution - 0214, Suita-shi

770-8503

Local Institution - 0185, Tokushima

181-8611

Local Institution - 0182, Mitaka-shi

162-8655

Local Institution - 0186, Shinjuku-ku

734-8551

Local Institution - 0179, Hiroshima

213-8587

Local Institution - 0197, Kanagawa

06700

Local Institution - 0148, Cuauhtémoc

6229 HX

Local Institution - 0263, Maastricht

3584CX

Local Institution - 0260, Utrecht

00927

Local Institution - 0231, San Juan

022328

Local Institution - 0078, Bucharest

06351

Local Institution - 0127, Seoul

03080

Local Institution - 0128, Seoul

03722

Local Institution - 0168, Seoul

05505

Local Institution - 0167, Seoul

06591

Local Institution - 0195, Seoul

08308

Local Institution - 0189, Seoul

08035

Local Institution - 0069, Barcelona

08036

Local Institution - 0031, Barcelona

08208

Local Institution - 0010, Sabadell (Barcelona)

NW3 2QG

Local Institution - 0111, London

SE5 9RS

Local Institution - 0092, London

W12 0HS

Local Institution - 0153, London

M20 4BX

Local Institution - 0114, Manchester

CH63 4JY

Local Institution - 0142, Metropolitan Borough of Wirral

Sponsors
All Listed Sponsors
collaborator

Ono Pharmaceutical Co. Ltd

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY

NCT03383458 - A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation | Biotech Hunter | Biotech Hunter