Safety and Efficacy of Pembrolizumab (MK-3475) in Combination With TS-1+Cisplatin or TS-1+Oxaliplatin as First Line Chemotherapy in Gastric Cancer (MK-3475-659/KEYNOTE-659)

PHASE2CompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

March 26, 2018

Primary Completion Date

May 30, 2021

Study Completion Date

May 30, 2021

Conditions
Gastric Cancer
Interventions
BIOLOGICAL

Pembrolizumab

200 mg Q3W on Day 1 by IV infusion

DRUG

Oxaliplatin

130 mg/m\^2 Q3W on Day 1 by IV infusion

DRUG

TS-1

40 to 60 mg orally according to Body Surface Area (BSA) BID Q3W on Days 1-14

DRUG

Cisplatin

60 mg/m\^2 Q3W on Day 1 by IV infusion

Trial Locations (25)

277-8577

National Cancer Center Hospital East ( Site 0001), Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center ( Site 0024), Matsuyama

373-8550

Gunma Prefectural Cancer Center ( Site 0005), Ohta

060-8648

Hokkaido University Hospital ( Site 0006), Sapporo

673-8558

Hyogo Cancer Center ( Site 0016), Akashi

650-0047

Kobe City Medical Center General Hospital ( Site 0015), Kobe

309-1793

Ibaraki Prefectural Central Hospital ( Site 0018), Kasama

252-0375

Kitasato University Hospital ( Site 0019), Sagamihara

241-8515

Kanagawa Cancer Center ( Site 0003), Yokohama

980-8574

Tohoku University Hospital ( Site 0023), Sendai

589-8511

Kindai University Hospital ( Site 0013), Sayama

565-0871

Osaka University Hospital ( Site 0010), Suita

362-0806

Saitama Cancer Center ( Site 0004), Kitaadachi-gun

411-8777

Shizuoka Cancer Center Hospital and Research Institute ( Site 0020), Sunto-gun

329-0498

Jichi Medical University Hospital ( Site 0009), Shimotsuke

260-8717

Chiba Cancer Center ( Site 0012), Chiba

811-1395

National Hospital Organization Kyushu Cancer Center ( Site 0017), Fukuoka

812-8582

Kyushu University Hospital ( Site 0014), Fukuoka

501-1194

Gifu University Hospital ( Site 0021), Gifu

781-8555

Kochi Health Sciences Center ( Site 0022), Kochi

860-8556

Kumamoto University Hospital ( Site 0002), Kumamoto

541-8567

Osaka International Cancer Institute ( Site 0011), Osaka

104-0045

National Cancer Center Hospital ( Site 0025), Tokyo

113-8677

Tokyo Metropolitan Komagome Hospital ( Site 0008), Tokyo

135-8550

The Cancer Institute Hospital of JFCR ( Site 0007), Tokyo

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03382600 - Safety and Efficacy of Pembrolizumab (MK-3475) in Combination With TS-1+Cisplatin or TS-1+Oxaliplatin as First Line Chemotherapy in Gastric Cancer (MK-3475-659/KEYNOTE-659) | Biotech Hunter | Biotech Hunter