Defining Antibiotic Treatment Duration for Ventilator - Associated Lung Infection

PHASE3CompletedINTERVENTIONAL
Enrollment

460

Participants

Timeline

Start Date

February 21, 2018

Primary Completion Date

January 23, 2023

Study Completion Date

March 22, 2023

Conditions
Ventilator Associated PneumoniaPneumonia, Bacterial
Interventions
DRUG

Reducing Antibiotics treatment duration

Antibiotics should be stopped from day 3 to 7 if respiratory cultures are negative and the patients fulfill a set of stringent clinical criteria signifying cardiopulmonary stability for 48 hours. If the respiratory cultures are positive, patients who fulfill the same set of clinical criteria should have their antibiotics stopped from day 5 to 7.

DRUG

Standard Antibiotics treatment duration

Participants in the control (long duration) arm will receive standard care, which is antibiotic treatment for at least 8 days with the exact duration decided by the primary physician.

Trial Locations (7)

Unknown

Civil Hospital, Kathmandu

Patan Academy of Health Science, Patan Hospital, Kathmandu, Patan

National University Hospital, Singapore, Singapore

Tan Tock Seng Hospital, Singapore

Khon Kaen Hospital, Khon Kaen

Srinagarind Hospital, Khon Kaen

Sunpasitthiprasong Hospital, Ubon Ratchathani

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Medical Research Council

OTHER_GOV

collaborator

Department for International Development, United Kingdom

OTHER_GOV

collaborator

Mahidol Oxford Tropical Medicine Research Unit

OTHER

lead

University of Oxford

OTHER