Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3)

PHASE3CompletedINTERVENTIONAL
Enrollment

571

Participants

Timeline

Start Date

February 10, 2018

Primary Completion Date

October 16, 2024

Study Completion Date

October 16, 2024

Conditions
Pancreas Adenocarcinoma
Interventions
DEVICE

NovoTTF-200T

Patients receive continuous TTFields treatment using the NovoTTF-200T device. TTFields treatment will consist of wearing four electrically insulated electrode arrays on the torso. The treatment enables the patient to maintain regular daily routine.

DRUG

Gemcitabine

Gemcitabine 1000 mg/m\^2 over 30 minute infusion will be administered immediately after nab-paclitaxel on Days 1, 8 and 15 of each 28-day cycle.

DRUG

nab paclitaxel

nab-paclitaxel 125 mg/m\^2 administered as an intravenous infusion over 30-40 minutes on Days 1, 8 and 15 of each 28-day cycle.

Trial Locations (199)

1070

Faculté de Médecine Campus Erasme, Anderlecht

1122

National Institute of Oncology, Budapest

1200

Clinique Universutaire Saint Luc - Institut Roi Albert II, Woluwe-Saint-Lambert

1708

Hôpital Fribourgeois/Freiburger Spital, Fribourg

3000

UZ Leuven, Leuven

4120

Greenslopes Private Hospital, Greenslopes

4400

Landes-Krankenhaus Steyr, Steyr

5000

Jasz-Nagykun-Szolnok County Hospital, Szolnok

5020

Univ. Klinik für Innere Medizin III der PMU, Salzburg

5700

Bekes County Hospital, Gyula

6000

Bacs-Kiskun County Hospital, Kecskemét

6150

St. John of God Murdoch Hospital, Murdoch

7100

Tolna County Hospital, Szekszárd

8401

KS Winterthur, Winterthur

9020

Klinikum Klagenfurt am Wörthersee, Klagenfurt

10000

University Hospital Centre Zagreb, Zagreb

10126

A.O.U Città della Salute e della Scienza di Torino, Torino

10408

National Cancer Center, Gyeonggi-do

10601

White Plains Hospital - Center for Cancer Care, White Plains

11042

NYU Langone Arena Oncology, Lake Success

11355

New York Hospital Queens, Flushing

13326

Bassett Medical Center, Cooperstown

13620

Seoul National University Bundang Hospital, Seongnam-si

14210

Kaleida Health, Buffalo

15121

A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria

16499

Ajou University Hospital, Suwon

17070

Medical University Graz, Graz

17822

Geisinger Medical Center, Danville

18015

Vita Medical Associates, P.C., Fountain Hill

20116

Centro de Investigación Médica Aguascalientes (CIMA),, Aguascalientes

21044

Maryland Oncology Hematology, P.A - US Oncology Research, Columbia

21201

University of Maryland Comprehensive Cancer Center, Baltimore

21565

Gachon University Gil Hospital, Incheon

22190

Hôpital Privé des Côtes d'Armor, Plérin

22271

Instituto D'Or de Pesquisa e Ensino - Rio De Janeiro, Rio de Janeiro

22332

Inha University Hospital, Incheon

24014

Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care - US Oncology Research, Roanoke

26506

West Virginia University Cancer Institute, Morgantown

27103

Novant Health Oncology Specialists, Winston-Salem

28050

HM Hospitales - Centro Integral Oncologico Clara Campal - CIOCC, Madrid

29010

Hospital Regional Universitario de Málaga, Málaga

30318

Piedmont Cancer Institute, Atlanta

31008

Clinica Universiatria de Navarra, Pamplona

31210

Mediadvance Clinical, Chihuahua City

32224

Mayo Clinic Hospital - Florida, Jacksonville

32804

AdventHealth Neuro Oncology, Orlando

33140

Mount Sinai Medical Center, Miami Beach

33324

BRCR Medical Center INC, Plantation

33486

Boca Raton Regional Hospital, Lynn Cancer Institute, Boca Raton

33604

Hopital haut-Léveque CHU Bordeaux - Service d'Hépato- Gastroentérologie et d'Oncologie digestive, Pessac

33613

Florida Hospital Tampa, Tampa

33705

Florida Cancer Specialists, St. Petersburg

33905

Florida Cancer Specialists & Research Institute - Colonial Office, Fort Myers

35243

Grandview Medical Center, Cancer Center, Birmingham

36607

Infirmary Cancer Care, Mobile

37203

Tennessee Oncology, Nashville

37403

UT/Erlanger Oncology & Hematology, Chattanooga

40202

Norton Cancer Institute, Norton Healthcare Pavilion, Louisville

41017

Saint Elizabeth Healthcare, Edgewood

41253

Hospital São Rafael, São Marcos

42601

Keimyung University, Dongsan hospital, Daegu

44614

Toledo Clinic Cancer Centers, Toledo

44718

Gabrail Cancer Research Center, Canton

46009

Instituto Valenciano de Oncología IVO, Valencia

48201

Karmanos Cancer Institute, Detroit

49055

Institut de Cancérologie de l'Ouest, Angers

49503

Cancer and Hematology Centers of Western Michigan, PC, Grand Rapids

49808

Bonifatius Hospital Hematology and Oncology, Lingen

50080

Centro Hemato-Oncologico Privado CHOP, Toluca

50134

Azienda Ospedaliero-Universitaria Careggi, Florence

50180

Phylasis Clinicas Research S.de R.L. de C.V. (PCR)-Toluca, Toluca

54750

Hospitales Star Medica - Luna Parc, Estado de México

54769

Phylasis Clinicas Research S. de R.L. de C.V., Cuautitlán Izcalli

55455

University of Minnesota, Minneapolis

56322

Centre Hospitalier de Bretagne Sud /Site du Scorff, Lorient

58128

Chonnam National University Hwasun Hospital, Hwasun

60005

Illinois Cancer Specialist - US Oncology Research, Arlington Heights

60153

Loyola University Medical Center, Maywood

60200

Masaryk Institute of Oncology, Brno střed

60201

NorthShore University HealthSystem, Evanston

60612

Rush University Medical Center, Chicago

64000

Accelerium S de RL de C.V., Monterrey

64132

MidAmerica Division, Kansas City

64239

Sourasky Medical Center, Oncology Department, Tel Aviv

64460

"Universidad Autonoma de Nuevo Leon - Hospital Universitario Dr. Jose Eleuterio Gonzalez", Monterrey

66205

University of Kansas Medical Cancer Center, Fairway

66606

Cotton O'Neil Cancer Center (Stormont-Vail Cancer Center), Topeka

67000

Centre de Lutte Contre le Cancer (CLCC) - Centre Paul Strauss, Strasbourg

Clinique Sainte Anne - Groupe Hospitalier Saint-Vincent, Strasbourg Oncologie Libérale, Strasbourg

68114

Nebraska Methodist Hospital, Omaha

70121

Ochsner Medical Center, New Orleans

72530

Oncocenter - Puebla, Puebla City

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75012

Service d'Oncologie médicale du Pr. Andre, Hôpital Saint-Antoine, Paris

75203

Methodist Regional Cancer Center, Dallas

75246

Texas Oncology - Baylor - US Oncology Research, Dallas

75702

Texas Oncology - Tyler - US Oncology Research, Tyler

76022

Texas Oncology - Bedford - US Oncology Reasearch, Bedford

76508

Baylor Scott and White Medical Center, Temple

77030

Houston Methodist Cancer Center, Houston

77702

Texas Oncology - Beaumont Mamie McFaddin Ward Cancer Center - US Oncology Research, Beaumont

78200

Hospital Angeles San Luis, San Luis Potosí City

78250

Centro Potosino de Investigación Médica SC,, San Luis Potosí City

79915

Texas Oncology - El Paso Cancer Treatment Center Gateway - US Oncology Research, El Paso

81925

Klinikum München Bogenhausen, Klinik für Gastroenterologie und Gastroenterologische Onkologie, München

82110

Centro de Estudios de Alta Especialidad de Sinaloa, ubicado, Mazatlán

84036

VK und K Studien GbR Landshut-Achdorf, Landshut

85234

Banner MD Anderson Cancer Center, Gilbert

85711

Arizona Oncology Associates, PC- HOPE - US Oncology Research, Tucson

88020

Centro de Pesquisa Clínica e Ensino Florianópolis LTDA, Florianópolis

89102

OptumCare Cancer Care, Las Vegas

89502

Renown Institute for Heart & Vascular Health, Reno

89619

Comprehensive Cancer Centers of Nevada, Las Vegas

90035

Hospital de Clínicas de Porto Alegre, Porto Alegre

90048

Cedars-Sinai Medical Center, Los Angeles

90610

Hospital São Lucas da PUCRS, Porto Alegre

91900

FAICIC Clinical Research, Veracruz

92801

Pacific Cancer Medical Center, Anaheim

92835

St. Joseph Heritage Healthcare - Virginia K. Crosson Cancer Center, Fullerton

93105

Ridley-Tree Cancer Center, Santa Barbara

94574

Adventist Health St. Helena - Martin-O'Neil Cancer Center (MOCC), St. Helena

95816

Dignity Health - Mercy Cancer Centers, Sacramento

Sutter Cancer Center Sacramento, Sacramento

97401

Willamette Valley Cancer Institute and Research Center - US Oncology Research, Eugene

98101

Virginia Mason Medical Center, Seattle

98109

Seattle Cancer Care Alliance, Seattle

98506

Vista Oncology Inc PS, Olympia

98700

Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí

100142

Beijing Cancer Hospital, Beijing

130021

The first hospital of Jilin University, Changchun

136100

Jilin Guowen Hospital, Jilin

150086

Harbin Medical University Cancer Hospital, Harbin

200433

Shanghai Changhai Hospital, Shanghai

276000

Linyi Cancer Hospital, Linyi

430000

Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan

430014

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510000

Sun Yat-sen Memorial Hospital Sun Yat-sen University, Guangzhou

Guangdong provincial people's hospital, Guangzhou

710061

The First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an

3109601

Rambam Health Care Campus, Oncology Institute, Haifa

4941492

Rabin Medical Center, Petah Tikva

5268102

Hadassah Medical Center, Ramat Gan

85724-5024

University of Arizona Cancer Center, Tucson

06460

Associated Neurologists of Southern Connecticut, P.C., Milford

04240

Central Maine Medical Center, Clinical Research Department, Lewiston

02215

Beth Israel Deaconess Medical Center, Boston

01605

UMass Memorial Medical Center, Worcester

08816

Astera Cancer Care, East Brunswick

37909-1327

Tennessee Cancer Specialists, Knoxville

VIC 3168

Monash Medical Centre, Clayton

NSW 2076

Sydney Adventist Hospital, Wahroonga

NSW 2145

Westmead Hosptial, Westmead

90020-090

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre

14015-130

IRPCc - Instituto Ribeirãopretano de Combate ao Câncer, Ribeirão Preto

22250-040

Oncoclinicas Group Botafogo, Rio de Janeiro

22775-001

Groupo Clinicas Oncologicas Integradas (COI) - Barra da Tijuca, Rio de Janeiro

41253-190

Instituto D´Or de Pesquisa e Ensino - Hospital São Rafael, São Marcos

04014-002

Núcleo de Pesquisa Clínica da Rede São Camilo, São Paulo

04543-000

Onco Star SP Oncologia LTDA, São Paulo

04543

Clínica OncoStar - REDE D´OR, São Paulo

N6A 5W9

London Regional Cancer Program, London Health Sciences Centre, London

H2X 3E4

Centre Hospitalier de I'Universitaire de de Montreal (CHUM), Montreal

J1G 1B1

Centre Hospitalier Universitaire de Sherbrooke CIUSSS de l'Estrie - CHUS, Sherbrooke

Unknown

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou

Peking Union Medical College Hospital, Beijing

Peking University People'S Hospital, Beijing

Xingtai People's Hospital, Xingtai

Henan Provincial Peoples Hospital, Zhengzhou

Centre Léon Bérard, Lyon

Medizinische Hochschule Hannover, Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Hanover

Queen Mary Hospital, Hong Kong

Sheba Pancreatic Cancer Center - SPCC, Ramat Gan

CHA Bundang Medical Center, CHA University, Seongnam-si

Vall d´Hebron University Hospital, Barcelona

Hospital General Universitario de Elche, Elche

Hospital Universitario Marqués de Valdecilla, Santander

030013

Shanxi Provincial Cancer Hospital, Shanxi

741 01

Nemocnice Nový Jičín, Nový Jičín

779 00

University Hospital Olomouc, Olomouc

128 08

General University Hospital in Prague, Prague

180 81

Nemocnice Na Bulovce, Prague

09116

Klinikum Chemnitz gGmbH, Chemnitz

06217

Carl-von-Basedow-klinikum Saalekrei, Merseburg

D-89081

Universitätsklinikum Ulm, Ulm

00128

Università Campus Bio-Medico di Rome, Roma

00186

Ospedale San Giovanni Calibita Fatebenefratelli Isola Tiberina, Roma

06700

Clinstile S.A. de C.V.,, Cuauhtémoc

60-596

Oncology Clinic Clinical Hospital of Przemienienia Pańskiego UM in Poznaniu, Poznan

35-021

Centrum Medyczne MrukMed, Rzeszów

02-034

Oncology and Radiotherapy Clinic, Oncology Center - Institute, Warsaw

02-507

Oncology and Radiotherapy Clinic University Clinical Center Non-Invasive Medicine Center, Warsaw

50-556

Jan Mikulicz-Radecki University Teaching Hospital, Wroclaw

602-715

Dong-A University Hospital, Seogu

03722

Severance Hospital, Yonsei University Health System, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

08308

Korea University Guro Hospital, Seoul

08028

Instituto Oncòlogico Dr. Rosell, Barcelona

All Listed Sponsors
lead

NovoCure Ltd.

INDUSTRY

NCT03377491 - Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3) | Biotech Hunter | Biotech Hunter