Interest of Oxygenated Hypothermic Perfusion (PHO) in Preservation of Hepatic Grafts From Expanded Criteria Donors

NACompletedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

February 19, 2018

Primary Completion Date

February 7, 2019

Study Completion Date

February 7, 2019

Conditions
Hepatocellular Injury
Interventions
DEVICE

Hypothermic oxygenated perfusion (HOPE)

25 patients: Application of HOPE for 2 hours, perfusion rate 100-150 ml/min, pressure controlled, perfusion pressure \< 3 mm Hg, perfusion route portal vein, recirculating system, perfusion volume 2 L, perfusate solution (UWMP®), perfusate temperature 4-12 °C, perfusate oxygenation 40 KPa

OTHER

Conventional cold storage

75 patients transplanted in Rennes between 2010 and 2015 with a cold stored grafts, matched (ratio 1: 3) using a propensity score calculated according to some parameters

Trial Locations (1)

35033

CHU de Rennes, Rennes

All Listed Sponsors
lead

Rennes University Hospital

OTHER

NCT03376074 - Interest of Oxygenated Hypothermic Perfusion (PHO) in Preservation of Hepatic Grafts From Expanded Criteria Donors | Biotech Hunter | Biotech Hunter