298
Participants
Start Date
October 26, 2018
Primary Completion Date
August 23, 2023
Study Completion Date
August 19, 2026
Biospecimen Collection
Undergo blood and urine sample collection
Cabozantinib S-malate
Given PO
Computed Tomography
Undergo CT
Magnetic Resonance Imaging
Undergo MRI
Placebo Administration
Given PO
Quality-of-Life Assessment
Ancillary studies
X-Ray Imaging
Undergo x-ray
Mount Sinai Hospital, New York
Memorial Sloan Kettering Cancer Center, New York
Memorial Sloan Kettering Westchester, Harrison
Memorial Sloan Kettering Nassau, Uniondale
Memorial Sloan Kettering Commack, Commack
Hematology Oncology Associates of Central New York-Auburn, Auburn
Hematology Oncology Associates of CNY at Camillus, Camillus
Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse
Roswell Park Cancer Institute, Buffalo
Wilmot Cancer Institute at Webster, Webster
University of Rochester, Rochester
Jefferson Hospital, Jefferson Hills
Wexford Health and Wellness Pavilion, Wexford
Forbes Hospital, Monroeville
Allegheny General Hospital, Pittsburgh
West Penn Hospital, Pittsburgh
Saint Vincent Hospital, Erie
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Lehigh Valley Hospital-Cedar Crest, Allentown
Lehigh Valley Hospital-Hazleton, Hazleton
Pocono Medical Center, East Stroudsburg
Thomas Jefferson University Hospital, Philadelphia
Fox Chase Cancer Center, Philadelphia
Temple University Hospital, Philadelphia
MedStar Georgetown University Hospital, Washington D.C.
Edwards Comprehensive Cancer Center, Huntington
West Virginia University Healthcare, Morgantown
Southeastern Medical Oncology Center-Goldsboro, Goldsboro
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Marion L Shepard Cancer Center - ECU Health Beaufort Hospital, Washington
Southeastern Medical Oncology Center-Clinton, Clinton
ECU Health Oncology Kinston, Kinston
Southeastern Medical Oncology Center-Jacksonville, Jacksonville
Margaret R Pardee Memorial Hospital, Hendersonville
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Prisma Health Cancer Institute - Butternut, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Prisma Health Cancer Institute - Easley, Easley
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
GenesisCare USA - Aventura FP, Aventura
GenesisCare USA - Aventura, Aventura
GenesisCare USA - Boca Ration FP06, Boca Raton
Moffitt Cancer Center, Tampa
Regional Cancer Center-Lee Memorial Health System, Fort Myers
University of Kentucky/Markey Cancer Center, Lexington
Delaware Health Center-Grady Cancer Center, Delaware
Licking Memorial Hospital, Newark
Ohio State University Comprehensive Cancer Center, Columbus
Columbus Oncology and Hematology Associates Inc, Columbus
Grant Medical Center, Columbus
The Mark H Zangmeister Center, Columbus
Doctors Hospital, Columbus
OhioHealth Marion General Hospital, Marion
Toledo Clinic Cancer Centers-Maumee, Maumee
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee
Mercy Health - Perrysburg Hospital, Perrysburg
Mercy Health - Saint Anne Hospital, Toledo
Toledo Clinic Cancer Centers-Toledo, Toledo
Genesis Healthcare System Cancer Care Center, Zanesville
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
Case Western Reserve University, Cleveland
UHHS-Chagrin Highlands Medical Center, Beachwood
University Hospitals Parma Medical Center, Parma
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights
UH Seidman Cancer Center at Saint John Medical Center, Westlake
University Hospitals Sharon Health Center, Wadsworth
OhioHealth Mansfield Hospital, Mansfield
Upper Valley Medical Center, Troy
Miami Valley Hospital, Dayton
Premier Blood and Cancer Center, Dayton
Miami Valley Hospital North, Dayton
Miami Valley Hospital South, Centerville
Adena Regional Medical Center, Chillicothe
Southern Ohio Medical Center, Portsmouth
Strecker Cancer Center-Belpre, Belpre
Marietta Memorial Hospital, Marietta
Memorial Hospital of South Bend, South Bend
McLaren Cancer Institute-Macomb, Mount Clemens
Henry Ford Saint John Hospital - Macomb Medical, Macomb
Henry Ford Warren Hospital - Breast Macomb, Macomb
Henry Ford River District Hospital, East China Township
Huron Medical Center PC, Port Huron
Lake Huron Medical Center, Port Huron
McLaren-Port Huron, Port Huron
Advanced Breast Care Center PLLC, Warren
Henry Ford Health Warren Hospital, Warren
Henry Ford Madison Heights Hospital - Breast, Warren
Henry Ford Warren Hospital - GLCMS, Warren
Macomb Hematology Oncology PC, Warren
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
Huron Gastroenterology PC, Ypsilanti
University of Michigan Comprehensive Cancer Center, Ann Arbor
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
Trinity Health Medical Center - Brighton, Brighton
Chelsea Hospital, Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
Hope Cancer Clinic, Livonia
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Toledo Clinic Cancer Centers-Monroe, Monroe
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
Trinity Health Medical Center - Canton, Canton
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
Henry Ford Health Saint John Hospital, Detroit
Henry Ford Saint John Hospital - Academic, Grosse Pointe Woods
Henry Ford Saint John Hospital - Breast, Grosse Pointe Woods
Henry Ford Saint John Hospital - Van Elslander, Grosse Pointe Woods
Henry Ford Rochester Hospital, Rochester Hills
Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights
Weisberg Cancer Treatment Center, Farmington Hills
Hope Cancer Center, Pontiac
Michigan Healthcare Professionals Pontiac, Pontiac
Newland Medical Associates-Pontiac, Pontiac
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
Hematology Oncology Consultants-Clarkston, Clarkston
McLaren Cancer Institute-Clarkston, Clarkston
Newland Medical Associates-Clarkston, Clarkston
Saint Mary's Oncology/Hematology Associates of Marlette, Marlette
Cancer Hematology Centers - Flint, Flint
Genesee Hematology Oncology PC, Flint
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
McLaren Cancer Institute-Flint, Flint
Singh and Arora Hematology Oncology PC, Flint
MyMichigan Medical Center Saginaw, Saginaw
Oncology Hematology Associates of Saginaw Valley PC, Saginaw
Saint Mary's Oncology/Hematology Associates of West Branch, West Branch
Caro Cancer Center, Caro
MyMichigan Medical Center Tawas, Tawas City
McLaren Cancer Institute-Central Michigan, Mount Pleasant
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing
University of Michigan Health - Sparrow Lansing, Lansing
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Beacon Kalamazoo Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Hickman Cancer Center, Adrian
McLaren Cancer Institute-Northern Michigan, Petoskey
Mercy Medical Center-West Lakes, West Des Moines
Iowa Methodist Medical Center, Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
Broadlawns Medical Center, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
UI Healthcare Mission Cancer and Blood - Fort Dodge, Fort Dodge
Greater Regional Medical Center, Creston
Heartland Oncology and Hematology LLP, Council Bluffs
Methodist Jennie Edmundson Hospital, Council Bluffs
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Mercy Hospital, Cedar Rapids
Oncology Associates at Mercy Medical Center, Cedar Rapids
University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
ProHealth D N Greenwald Center, Mukwonago
ProHealth Waukesha Memorial Hospital, Waukesha
UW Cancer Center at ProHealth Care, Waukesha
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Cancer Center of Western Wisconsin, New Richmond
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Medical Center - Minocqua, Minocqua
Marshfield Medical Center-EC Cancer Center, Eau Claire
Duluth Clinic Ashland, Ashland
Marshfield Medical Center-Rice Lake, Rice Lake
ThedaCare Regional Cancer Center, Appleton
Essentia Health Sandstone, Sandstone
Lakeview Hospital, Stillwater
Fairview Lakes Medical Center, Wyoming
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Minnesota Oncology Hematology PA-Maplewood, Maplewood
Saint John's Hospital - Healtheast, Maplewood
Minnesota Oncology Hematology PA-Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Minnesota Oncology - Burnsville, Burnsville
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
Saint Francis Regional Medical Center, Shakopee
Ridgeview Medical Center, Waconia
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
North Memorial Medical Health Center, Robbinsdale
Unity Hospital, Fridley
Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Health Partners Inc, Minneapolis
Essentia Health Hibbing Clinic, Hibbing
Essentia Health Virginia Clinic, Virginia
Essentia Health Cancer Center, Duluth
Mayo Clinic in Rochester, Rochester
New Ulm Medical Center, New Ulm
Rice Memorial Hospital, Willmar
Sanford Joe Lueken Cancer Center, Bemidji
Essentia Health - Deer River Clinic, Deer River
Sanford Cancer Center Oncology Clinic, Sioux Falls
Sanford Broadway Medical Center, Fargo
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Billings Clinic Cancer Center, Billings
Saint Vincent Frontier Cancer Center, Billings
Benefis Sletten Cancer Institute, Great Falls
Great Falls Clinic, Great Falls
Saint Peter's Community Hospital, Helena
Saint James Community Hospital and Cancer Treatment Center, Butte
Community Hospital of Anaconda, Anaconda
Bozeman Health Deaconess Hospital, Bozeman
Community Medical Center, Missoula
Logan Health Medical Center, Kalispell
Loyola University Medical Center, Maywood
UC Comprehensive Cancer Center at Silver Cross, New Lenox
University of Chicago Medicine-Orland Park, Orland Park
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Illinois CancerCare-Dixon, Dixon
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Peru, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare - Washington, Washington
Illinois CancerCare-Peoria, Peoria
Illinois CancerCare-Bloomington, Bloomington
Carle Cancer Center, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
Cancer Care Center of O'Fallon, O'Fallon
Illinois CancerCare-Carthage, Carthage
Carle Physician Group-Effingham, Effingham
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Missouri Baptist Sullivan Hospital, Sullivan
Washington University School of Medicine, St Louis
BJC Outpatient Center at Sunset Hills, Sunset Hills
Siteman Cancer Center-South County, St Louis
Missouri Baptist Medical Center, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Parkland Health Center-Bonne Terre, Bonne Terre
Parkland Health Center - Farmington, Farmington
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
Saint Francis Medical Center, Cape Girardeau
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC, Omaha
Nebraska Methodist Hospital, Omaha
Oncology Associates PC, Omaha
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island
Oncology Center of The South Incorporated, Houma
Northshore Oncology Associates-Covington, Covington
LSU Health Baton Rouge-North Clinic, Baton Rouge
Our Lady of the Lake Physician Group, Baton Rouge
Our Lady of The Lake, Baton Rouge
Louisiana Hematology Oncology Associates LLC, Baton Rouge
Mary Bird Perkins Cancer Center, Baton Rouge
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
Rocky Mountain Cancer Centers-Aurora, Aurora
Good Samaritan Hospital - Cancer Centers of Colorado, Lafayette
Mountain Blue Cancer Care Center - Swedish, Englewood
Swedish Medical Center, Englewood
Rocky Mountain Cancer Centers-Littleton, Littleton
Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree
National Jewish Health-Main Campus, Denver
Rocky Mountain Cancer Centers-Midtown, Denver
Saint Joseph Hospital - Cancer Centers of Colorado, Denver
Rocky Mountain Cancer Centers-Rose, Denver
National Jewish Health-Northern Hematology Oncology, Thornton
Rocky Mountain Cancer Centers-Boulder, Boulder
National Jewish Health-Western Hematology Oncology, Golden
Intermountain Health Lutheran Hospital, Wheat Ridge
Banner McKee Medical Center, Loveland
Banner North Colorado Medical Center, Greeley
Penrose-Saint Francis Healthcare, Colorado Springs
Saint Mary's Hospital and Regional Medical Center, Grand Junction
Billings Clinic-Cody, Cody
Welch Cancer Center, Sheridan
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
Walter Knox Memorial Hospital, Emmett
Saint Luke's Cancer Institute - Fruitland, Fruitland
Idaho Urologic Institute-Meridian, Meridian
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Alphonsus Cancer Care Center-Nampa, Nampa
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Cancer Institute - Boise, Boise
Kootenai Health - Coeur d'Alene, Coeur d'Alene
Kootenai Clinic Cancer Services - Post Falls, Post Falls
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
Farmington Health Center, Farmington
University of Utah Sugarhouse Health Center, Salt Lake City
Huntsman Cancer Institute/University of Utah, Salt Lake City
Mayo Clinic Hospital in Arizona, Phoenix
Banner University Medical Center - Tucson, Tucson
University of Arizona Cancer Center-North Campus, Tucson
Kingman Regional Medical Center, Kingman
University of New Mexico Cancer Center, Albuquerque
New Mexico Oncology Hematology Consultants, Albuquerque
Presbyterian Kaseman Hospital, Albuquerque
Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho
Hope Cancer Care of Nevada-Pahrump, Pahrump
Cancer and Blood Specialists-Henderson, Henderson
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson
Las Vegas Cancer Center-Henderson, Henderson
OptumCare Cancer Care at Seven Hills, Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
Oncology Las Vegas - Henderson, Henderson
Desert West Surgery, Las Vegas
OptumCare Cancer Care at Charleston, Las Vegas
University Medical Center of Southern Nevada, Las Vegas
Hope Cancer Care of Nevada, Las Vegas
Cancer and Blood Specialists-Shadow, Las Vegas
Radiation Oncology Centers of Nevada Central, Las Vegas
GenesisCare USA - Las Vegas, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas
Radiation Oncology Centers of Nevada Southeast, Las Vegas
Cancer Therapy and Integrative Medicine, Las Vegas
Ann M Wierman MD LTD, Las Vegas
Cancer and Blood Specialists-Tenaya, Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas
Oncology Las Vegas - Tenaya, Las Vegas
OptumCare Cancer Care at MountainView, Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
GenesisCare USA - Fort Apache, Las Vegas
OptumCare Cancer Care at Fort Apache, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
University Cancer Center, Las Vegas
Renown Regional Medical Center, Reno
Saint Mary's Regional Medical Center, Reno
Radiation Oncology Associates, Reno
Carson Tahoe Regional Medical Center, Carson City
City of Hope Comprehensive Cancer Center, Duarte
PCR Oncology, Arroyo Grande
Kaiser Permanente-Fresno, Fresno
Salinas Valley Memorial, Salinas
Mills-Peninsula Medical Center, Burlingame
Palo Alto Medical Foundation-Camino Division, Mountain View
Kaiser Permanente-Redwood City, Redwood City
Kaiser Permanente-South San Francisco, South San Francisco
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
California Pacific Medical Center-Pacific Campus, San Francisco
Kaiser Permanente-San Francisco, San Francisco
UCSF Medical Center-Mission Bay, San Francisco
Palo Alto Medical Foundation Health Care, Palo Alto
Stanford Cancer Institute Palo Alto, Palo Alto
Mills Health Center, San Mateo
Kaiser Permanente-Deer Valley Medical Center, Antioch
Kaiser Permanente-Fremont, Fremont
Palo Alto Medical Foundation-Fremont, Fremont
Epic Care-Dublin, Dublin
Kaiser Permanente San Leandro, San Leandro
Kaiser Permanente-Vallejo, Vallejo
Sutter Solano Medical Center/Cancer Center, Vallejo
Kaiser Permanente-Walnut Creek, Walnut Creek
Epic Care Partners in Cancer Care, Emeryville
Alta Bates Summit Medical Center - Summit Campus, Oakland
Kaiser Permanente-Oakland, Oakland
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
Kaiser Permanente-Richmond, Richmond
Kaiser Permanente-San Rafael, San Rafael
Kaiser San Rafael-Gallinas, San Rafael
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz
Kaiser Permanente-Santa Teresa-San Jose, San Jose
Kaiser Permanente-Stockton, Stockton
Memorial Medical Center, Modesto
Kaiser Permanente-Modesto, Modesto
Kaiser Permanente-Santa Rosa, Santa Rosa
Sutter Auburn Faith Hospital, Auburn
Kaiser Permanente-Roseville, Roseville
Sutter Roseville Medical Center, Roseville
Kaiser Permanente Medical Center-Vacaville, Vacaville
Kaiser Permanente Downtown Commons, Sacramento
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Kaiser Permanente-South Sacramento, Sacramento
Fremont - Rideout Cancer Center, Marysville
Hawaii Cancer Care - Westridge, ‘Aiea
Pali Momi Medical Center, ‘Aiea
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu
Queen's Cancer Cenrer - POB I, Honolulu
Queen's Medical Center, Honolulu
Straub Clinic and Hospital, Honolulu
Queen's Cancer Center - Kuakini, Honolulu
Kaiser Permanente Moanalua Medical Center, Honolulu
Providence Cancer Institute Clackamas Clinic, Clackamas
Providence Newberg Medical Center, Newberg
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Saint Alphonsus Cancer Care Center-Baker City, Baker City
Saint Alphonsus Cancer Care Center-Ontario, Ontario
Virginia Mason Medical Center, Seattle
Katmai Oncology Group, Anchorage
Contra Costa Regional Medical Center, Martinez
Danbury Hospital, Danbury
Norwalk Hospital, Norwalk
Mayo Clinic in Florida, Jacksonville
Brigham and Women's Hospital, Boston
Boston Medical Center, Boston
Beth Israel Deaconess Medical Center, Boston
Dana-Farber Cancer Institute, Boston
Lahey Hospital and Medical Center, Burlington
Las Vegas Cancer Center-Medical Center, Las Vegas
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Dartmouth Cancer Center - Nashua, Nashua
Memorial Sloan Kettering Basking Ridge, Basking Ridge
Englewood Hospital and Medical Center, Englewood
Memorial Sloan Kettering Monmouth, Middletown
Memorial Sloan Kettering Bergen, Montvale
The Valley Hospital - Luckow Pavilion, Paramus
Valley Health System Ridgewood Campus, Ridgewood
Valley Medical Group - Wayne Multispecialty Practice, Wayne
Atrium Medical Center-Middletown Regional Hospital, Franklin
Sanford USD Medical Center - Sioux Falls, Sioux Falls
National Cancer Institute (NCI)
NIH