Testing Olaparib in Patients With Advanced or Metastatic (Cancer That Has Spread) Bladder Cancer and Other Genitourinary Tumors With DNA-Repair Genetic Changes

PHASE2RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

November 3, 2020

Primary Completion Date

December 16, 2025

Study Completion Date

December 16, 2025

Conditions
Advanced Bladder CarcinomaAdvanced Genitourinary System CarcinomaMetastatic Bladder CarcinomaMetastatic Genitourinary System CarcinomaStage III Bladder Cancer AJCC v8Stage IV Bladder Cancer AJCC v8
Interventions
PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood collection

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy

PROCEDURE

Bone Scan

Undergo bone scan

PROCEDURE

Computed Tomography

Undergo CT or PET/CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Olaparib

Given PO

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

Trial Locations (17)

10016

ACTIVE_NOT_RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10065

RECRUITING

NYP/Weill Cornell Medical Center, New York

20892

RECRUITING

NCI - Center for Cancer Research, Bethesda

40536

ACTIVE_NOT_RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

73104

ACTIVE_NOT_RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

90033

ACTIVE_NOT_RECRUITING

Los Angeles General Medical Center, Los Angeles

ACTIVE_NOT_RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

92024

RECRUITING

UC San Diego Health System - Encinitas, Encinitas

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92103

RECRUITING

UC San Diego Medical Center - Hillcrest, San Diego

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92663

ACTIVE_NOT_RECRUITING

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

SUSPENDED

University of California Davis Comprehensive Cancer Center, Sacramento

77555-0565

RECRUITING

University of Texas Medical Branch, Galveston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH